Evidence map›Paper›PMID 27469525›Full record

SynthesisInternational journal of colorectal disease2016

Surgery along the embryological planes for colon cancer: a systematic review of complete mesocolic excision.

Nikolaos Gouvas, Christos Agalianos, Kleio Papaparaskeva, Aristotelis Perrakis, Werner Hohenberger, Evaghelos Xynos

Registry-linked trialAbstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in International journal of colorectal disease, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05128708 (Safety and Feasibility of the Combined Medial and Caudal Approach in Open and Laparoscopic Radical Right Hemicolectomy for Right Colon Cancer), which is not on this map. Cited by 48 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 5 pooled it
5.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05128708 nacompletednot on this mapstarted 2020, after this paper: background citation

Safety and Feasibility of the Combined Medial and Caudal Approach in Open and Laparoscopic Radical Right Hemicolectomy for Right Colon Cancer

TypeinterventionalSponsorZagazig UniversityRan2020 to 2021Enrolled26ConditionsColon CancerArmscombined medial and caudal approach right hemicolectomy open and laparoscopic
3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 5 syntheses or guidelines pooled it, 99 citations in OpenAlex.

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  18. The Development of the Mesenteric Model of Abdominal Anatomy.Clinics in colon and rectal surgery · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 2 countries.

Nikolaos GouvasDepartment of General Surgery, Metropolitan Hospital, 9 Ethnarhou Makariou str, 18547, Pireus, Greece. nikos.gouvas@gmail.com.
Christos AgalianosDepartment of General Surgery, Naval & Veterans Hospital, Athens, Greece.
Kleio PapaparaskevaDepartment of Pathology, Konstantopouleio Hospital of Athens, Athens, Greece.
Aristotelis PerrakisDepartment of Surgery, University Hospital of Erlangen, Erlangen, Germany.
Werner HohenbergerDepartment of Surgery, University Hospital of Erlangen, Erlangen, Germany.
Evaghelos XynosDepartment of General Surgery, Creta InterClinic Hospital, Heraklion, Greece.
Universitätsklinikum Erlangen · DEAgia Olga Hospital · GRAthens Naval & Veterans Hospital · GRMetropolitan Hospital · GRPolyclinic General Hospital · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundComplete mesocolic excision (CME) for colonic cancer offers a surgical specimen of higher quality, with higher number of lymph nodes compared to conventional colectomy. However, evidence on oncological outcomes is limited. The aim of the present study is to review recent literature and provide more information regarding the effect of CME colectomy on short- and long-term outcomes.

methodPubMed and MEDLINE databases were searched, and articles in English reporting data on CME were reviewed. Intraoperative events; postoperative morbidity and mortality; histopathological characteristics, including macroscopic assessment, number, and status of retrieved lymph nodes; and oncological outcomes were the end-points.

resultsThirty-two studies were analyzed. As regards the macroscopic assessment, a larger specimen (p = 0.02) that contains a higher number of lymph nodes (p < 0.00001) is acquired after CME. Two studies report a higher disease-free survival, in stage I and II and particularly in stage III disease after CME. CME by laparoscopy offers comparable outcomes, as regards intraoperative blood loss and immediate postoperative morbidity and mortality rates. Specimen quality is similar after either approach, for cancers located at the right and left colon, but not at the transverse colon.

conclusionThere is strong evidence that CME offers a longer central pedicle that contains more lymph nodes than conventional surgery for colon cancer. CME represents the surgical background for the maximum lymph node harvest, an important quality marker for the surgical outcome. However, and according to present data, there is limited evidence that colectomy in terms of CME leads to improved long-term oncological outcomes.

Indexed as

AgedColectomyColonic NeoplasmsFemaleHumansLaparoscopyMaleMesocolonMiddle AgedPostoperative CarePostoperative ComplicationsTreatment OutcomeCentral vascular ligationColon cancerComplete mesocolic excisionMeta-analysisSystematic review

Identifiers

PMID27469525
OpenAlexW2479407096

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.