Evidence map›Paper›PMID 27469363›Full record

ReviewJournal of nuclear medicine : official publication, Society of Nuclear Medicine2016

Molecular Imaging of Immunotherapy Targets in Cancer.

Emily B Ehlerding, Christopher G England, Douglas G McNeel, Weibo Cai

Registry-linked trialAbstract readReview
In one paragraph

Review in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07481136 (A Phase I PET Imaging Study of 64Cu-GRIP B, a Radiotracer Targeting Granzyme B, in Patients With Acute Myocarditis), which is not on this map. Cited by 58 papers.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07481136 phase1not yet recruitingnot on this mapstarted 2026, after this paper: background citation

A Phase I PET Imaging Study of 64Cu-GRIP B, a Radiotracer Targeting Granzyme B, in Patients With Acute Myocarditis

TypeinterventionalSponsorJavid Moslehi, MDRan2026 to 2031Enrolled10ConditionsAcute MyocarditisArms64Cu-GRIP B is a radiolabeled peptide tracer, a copper-64 isotope bound to a peptide designed to target extracellular Granzyme B
3 · Its place in the literature

Who cites it

58 citing papers in PubMed.

  1. Article
  2. [Molecular imaging and biology · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Glucose-Thymidine Ratio as a Metabolism Index UsingInternational journal of molecular sciences · 2022
    Article
  13. Review
  14. Article
  15. Article
  16. Non-invasive molecular imaging of kidney diseases.Nature reviews. Nephrology · 2021
    Review
  17. Article
  18. Article
  19. Development of [European journal of nuclear medicine and molecular imaging · 2021
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Emily B EhlerdingDepartment of Medical Physics, University of Wisconsin-Madison, Madison, Wisconsin.
Christopher G EnglandDepartment of Medical Physics, University of Wisconsin-Madison, Madison, Wisconsin.
Douglas G McNeelDepartment of Medicine, University of Wisconsin-Madison, Madison, Wisconsin University of Wisconsin Carbone Cancer Center, Madison, Wisconsin; and.
Weibo CaiDepartment of Medical Physics, University of Wisconsin-Madison, Madison, Wisconsin University of Wisconsin Carbone Cancer Center, Madison, Wisconsin; and Department of Radiology, University of Wisconsin-Madison, Madison, Wisconsin wcai@uwhealth.org.

Funding

UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Christian Capitini · 1985 to 2026
$142.6M
U.W. RADIOLOGICAL SCIENCES TRAINING PROGRAMT32CA009206 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Bryan Patrick Bednarz · 1985 to 2026
$12.1M
Chemistry-Biology Interface Training ProgramT32GM008505 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI BLACKWELL, HELEN E. · 1993 to 2023
$9.8M
Membranous Nanogenerators for in vivo Bio-mechanical Energy HarvestingR01EB021336 · NIBIB · UNIVERSITY OF WISCONSIN-MADISON · PI WANG, XUDONG · 2016 to 2020
$1.7M
Novel Combination Therapy for Prostate CancerR01CA169365 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI CAI, WEIBO · 2013 to 2015
$903k
NCI NIH HHS P30 CA014520NCI NIH HHS R01 CA169365NCI NIH HHS T32 CA009206NIBIB NIH HHS R01 EB021336NIGMS NIH HHS T32 GM008505
6 · The paper itself

Abstract

Immunotherapy has emerged as a promising alternative in the arsenal against cancer by harnessing the power of the immune system to specifically target malignant tissues. As the field of immunotherapy continues to expand, researchers will require newer methods for studying the interactions between the immune system, tumor cells, and immunotherapy agents. Recently, several noninvasive imaging strategies have been used to map the biodistribution of immune checkpoint molecules, monitor the efficacy and potential toxicities of the treatments, and identify patients who are likely to benefit from immunotherapies. In this review, we outline the current applications of noninvasive techniques for the preclinical imaging of immunotherapy targets and suggest future pathways for molecular imaging to contribute to this developing field.

Indexed as

AnimalsHumansImmunotherapyMolecular ImagingMolecular Targeted TherapyNeoplasmsCTLA-4immune checkpointsimmunotherapyPD-1PD-L1positron emission tomography (PET)

Identifiers

PMID27469363
PMCPMC5050107

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.