ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2017
Matrix Metalloproteinase-Targeted Imaging of Lung Inflammation and Remodeling.
Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 34 citations in OpenAlex.
- Increased serum IL‑41 associated with acute exacerbation of chronic obstructive pulmonary disease.Experimental and therapeutic medicine · 2024Article
- Associations of MMP9 polymorphism with the risk of severe pneumonia in a Southern Chinese children population.BMC infectious diseases · 2024Article
- Lung Imaging in COPD Part 2: Emerging Concepts.Chest · 2023Review
- Nonsteroidal Anti-Inflammatory Drug Conjugated with Gadolinium (III) Complex as an Anti-Inflammatory MRI Agent.International journal of molecular sciences · 2023Article
- Molecular Imaging for Early-Stage Disease Diagnosis.Advances in experimental medicine and biology · 2023Article
- Dissecting the novel mechanism of reduning injection in treating Coronavirus Disease 2019 (COVID-19) based on network pharmacology and experimental verification.Journal of ethnopharmacology · 2021Article
- Molecular Imaging of Inflammatory Disease.Biomedicines · 2021Review
- Hydroxamate-Based Selective Macrophage Elastase (MMP-12) Inhibitors and Radiotracers for Molecular Imaging.Journal of medicinal chemistry · 2020Article
- Molecular Imaging Probes Based on Matrix Metalloproteinase Inhibitors (MMPIs).Molecules (Basel, Switzerland) · 2019Review
- Role of medical and molecular imaging in COPD.Clinical and translational medicine · 2019Review
- Article
- Expressions of MMP-12, TIMP-4, and Neutrophil Elastase in PBMCs and Exhaled Breath Condensate in Patients with COPD and Their Relationships with Disease Severity and Acute Exacerbations.Journal of immunology research · 2019Article
- Article
- Novel Arginine-containing Macrocyclic MMP Inhibitors: Synthesis,Scientific reports · 2018Article
- Playing slot to hitting the jackpot in molecular imaging: On probability of uncovering subcellular pathogenesis vs achieving clinical applicability.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018Article
- Molecular imaging of pulmonary diseases.Respiratory research · 2018Review
- Development of matrix metalloproteinase-targeted probes for lung inflammation detection with positron emission tomography.Scientific reports · 2018Article
- Regulation function of MMP-1 downregulated by siRNA on migration of heat-denatured dermal fibroblasts.Bioengineered · 2017Article
- Preclinical Evaluation of RYM1, a Matrix Metalloproteinase-Targeted Tracer for Imaging Aneurysm.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2017Article
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
Abstract
Imaging techniques for detection of molecular and cellular processes that precede or accompany lung diseases are needed. Matrix metalloproteinases (MMPs) play key roles in the development of pulmonary pathology. The objective of this study was to investigate the feasibility of in vivo MMP-targeted molecular imaging for detection of lung inflammation and remodeling.
methodsLung-specific IL-13 transgenic (Club cell 10-kDa protein [CC10]-IL-13 Tg) mice and wild-type littermates were used in this study. Lung structure, gene expression, and MMP activity were assessed by histology, real-time reverse transcription polymerase chain reaction, Western blotting, and zymography. MMP activation was imaged by in vivo small-animal SPECT/CT followed by ex vivo planar imaging. Signal specificity was addressed using a control tracer. The correlation between in vivo MMP signal and gene expression was addressed.
resultsCC10-IL-13 Tg mice developed considerable pulmonary tissue remodeling and inflammation. CD68, MMP-12, and MMP-13 were significantly higher in CC10-IL-13 Tg lungs. On in vivo small-animal SPECT/CT and ex vivo planar images, the MMP signal was significantly higher in the lungs of CC10-IL-13 Tg mice than wild-type animals. Furthermore, a nonbinding analog tracer showed significantly lower accumulation in CC10-IL-13 Tg lungs relative to the specific tracer. There was a significant correlation between small-animal SPECT/CT-derived MMP signal and CD68 expression in the lungs (r = 0.70, P < 0.01).
conclusionSmall-animal SPECT/CT-based MMP-targeted imaging of the lungs is feasible and reflects pulmonary inflammation. If validated in humans, molecular imaging of inflammation and remodeling can potentially help early diagnosis and monitoring of the effects of therapeutic interventions in pulmonary diseases.
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