ArticleThe Annals of thoracic surgery2017
Does Lymph Node Count Influence Survival in Surgically Resected Non-Small Cell Lung Cancer?
Article in The Annals of thoracic surgery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Ethnic Differences in Survival Among Lung Cancer Patients: A Systematic Review.JNCI cancer spectrum · 2021Pooled it
- Efficacy of Adjuvant Chemoimmunotherapy versus Chemotherapy and the Impact of Lymph Node Dissection on Survival.Annals of surgical oncology · 2026Article
- Association of resection type, nodal evaluation, and survival in early-stage lung squamous cell carcinoma.Journal of thoracic disease · 2026Article
- Risk-adapted nodal evaluation in stage IA non-small cell lung cancer: a population-based competing-risk analysis.World journal of surgical oncology · 2026Article
- A Retrospective Comparison of Oncologic and Staging Outcomes Between Surgical Procedures-Video-Assisted Thoracoscopic Surgery Versus Thoracotomy in Pulmonary Adenocarcinoma.Medicina (Kaunas, Lithuania) · 2026Article
- Prognostic impact of the lymph node yield on survival in patients with stage I lung adenocarcinoma receiving sublobar resection.Frontiers in molecular biosciences · 2026Article
- Not all major pathological responses are equal: prognostic heterogeneity and risk stratification after neoadjuvant chemoimmunotherapy in resectable NSCLC.Frontiers in immunology · 2026Article
- Customized transformer for lymph node metastasis prediction from lung adenocarcinoma histology in a multicentric study.NPJ precision oncology · 2025Article
- Influence of adjuvant chemotherapy on survival for patients with completely resected high-risk stage IB NSCLC.Journal of cardiothoracic surgery · 2024Article
- Defining Volume Targets for Regionalization of Pancreaticoduodenectomy, Esophagectomy, and Major Lung Resection Centers to Improve Oncologic and Surgical Outcomes.Annals of surgical oncology · 2024Article
- Association between number of dissected lymph nodes and survival in patients undergoing resection for clinical stage IA pure solid lung adenocarcinoma: a retrospective analysis.BMC pulmonary medicine · 2023Article
- Removing different number of regional lymph nodes affects survival outcomes of operable patients at stage IIA non-small cell lung cancer (according to the 8th edition staging).Journal of thoracic disease · 2023Article
- The Valuable Prognostic Impact of Regional Lymph Node Removed on Outcomes for IIIA N0 NSCLC Patients.Journal of Cancer · 2023Article
- Prognostic factors of survival in patients with non-small cell lung cancer: a competing risk model using the SEER database.Translational cancer research · 2022Article
- Lymph node ratio predicts overall survival in patients with stage II non-small cell lung cancer: a population-based SEER analysis.Discover oncology · 2022Article
- Prognostic implication of isolated pulmonary nodules in patients with a history of breast cancer.Journal of cardiothoracic surgery · 2022Article
- Review
- Robotic and video-assisted lobectomy/segmentectomy for non-small cell lung cancer have similar perioperative outcomes: a systematic review and meta-analysis.Translational cancer research · 2021Article
- The Independent Prognostic Effect of Lymph Node Dissection on Patients With Stage IA NSCLC With Different T Stages.Frontiers in surgery · 2021Article
- Video-assisted thoracoscopic surgery lobectomy might be a feasible alternative for surgically resectable pathological N2 non-small cell lung cancer patients.Thoracic cancer · 2021Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe prognostic significance of the number of lymph nodes sampled (NLNS) during resection for non-small cell lung cancer (NSCLC) is unclear. The NLNS is influenced by many factors, and some have argued that it should be a surrogate for quality. We sought to determine the influence of the NLNS on overall survival and cancer-specific survival for surgically resected NSCLC.
methodsThe California Cancer Registry was queried from 2004 to 2011 for cases of stage I to III NSCLC treated with surgical resection, identifying 16,393 patients. Kaplan-Meier and Cox proportional hazards modeling were used to determine the influence of NLNS on overall survival and cancer-specific survival.
resultsIn all, 15,195 patients had information regarding nodal sampling. Eighty percent (13,167 of 15,195) were treated with lobectomy. Patients who were younger, male, non-Hispanic white, highest socioeconomic status, higher stage, or larger size tumor had more nodes removed. Sampling fewer than 10 nodes was associated with poorer overall survival when compared with sampling 10 or more nodes after adjustment for demographic and clinical factors for stage I: overall survival hazard ratio 1.78 (95% confidence interval: 1.54 to 2.05, p < 0.0001), hazard ratio 1.43 (95% confidence interval: 1.27 to 1.59, p < 0.0001), and hazard ratio 1.16 (95% confidence interval: 1.05 to 1.28, p = 0.004), for 0, 1 to 3, and 4 to 10 nodes, respectively. Of patients who underwent sublobar resection, 43.8% had no nodes sampled.
conclusionsFor NSCLC, the NLNS influenced both overall survival and cancer-specific survival, but the influence is dependent on stage. Surgeons should perform mediastinal lymphadenectomy to maximize patient survival, but the optimal NLNS remains unclear.
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