Evidence map›Paper›PMID 27469325›Full record

ArticleEuropean journal of immunology2016

Scarcity of autoreactive human blood IgA

Julie Prigent, Valérie Lorin, Ayrin Kök, Thierry Hieu, Salomé Bourgeau, Hugo Mouquet

Registry-linked trialOpen access · hybridAbstract read
In one paragraph

Article in European journal of immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03925272 (Constitution d'Une Cohorte Prospective de Sujets Sains et Malades et d'Une Collection de Ressources Biologiques associées Pour l'étude du système Immunitaire et de Ses déterminants Génétiques et Environnementaux"), which is not on this map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03925272 naunknown statusnot on this map

Constitution d'Une Cohorte Prospective de Sujets Sains et Malades et d'Une Collection de Ressources Biologiques associées Pour l'étude du système Immunitaire et de Ses déterminants Génétiques et Environnementaux"

TypeinterventionalSponsorInstitut PasteurRan2011 to 2023Enrolled2,200ConditionsImmune System and Related DisordersArmsCollection of samples (blood, stool, etc.), Genetic determinants analysis, Sample obtained after surgery performed in the context of care
3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 41 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Julie PrigentLaboratory of Humoral Response to Pathogens, Department of Immunology, Institut Pasteur, Paris, France.
Valérie LorinLaboratory of Humoral Response to Pathogens, Department of Immunology, Institut Pasteur, Paris, France.
Ayrin KökLaboratory of Humoral Response to Pathogens, Department of Immunology, Institut Pasteur, Paris, France.
Thierry HieuLaboratory of Humoral Response to Pathogens, Department of Immunology, Institut Pasteur, Paris, France.
Salomé BourgeauLaboratory of Humoral Response to Pathogens, Department of Immunology, Institut Pasteur, Paris, France.
Hugo MouquetLaboratory of Humoral Response to Pathogens, Department of Immunology, Institut Pasteur, Paris, France. hugo.mouquet@pasteur.fr.
Institut Pasteur · FRCentre National de la Recherche Scientifique · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Class-switched memory B cells are key components of the "reactive" humoral immunity, which ensures a fast and massive secretion of high-affinity antigen-specific antibodies upon antigenic challenge. In humans, IgA class-switched (IgA

Indexed as

Antibody DiversityImmunologic MemoryAntibody AffinityAntibody FormationAutoantibodiesAutoantigensAutoimmunityB-LymphocytesClonal Selection, Antigen-MediatedClone CellsHumansImmunoglobulin AImmunoglobulin Class SwitchingImmunoglobulin GSingle-Cell AnalysisAutoantibodiesAutoantigensImmunoglobulin AImmunoglobulin GAutoreactivityIgA AntibodiesImmunoglobulin genesMemory B cellsPolyreactivity

Identifiers

PMID27469325
PMCPMC5113776
OpenAlexW2506206979

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.