ReviewTranslational research : the journal of laboratory and clinical medicine2017
The infant gut bacterial microbiota and risk of pediatric asthma and allergic diseases.
Review in Translational research : the journal of laboratory and clinical medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
82 citing papers in PubMed, 1 synthesis or guideline pooled it, 157 citations in OpenAlex.
- Classifying caesarean section to understand rising rates among Palestinian refugees: results from 290,047 electronic medical records across five settings.BMC pregnancy and childbirth · 2022Pooled it
- Childhood allergy is preceded by an absence of gut lactobacilli species and higher levels of atopy-related plasma chemokines.Clinical and experimental immunology · 2020Trial
- Supplementation with long-chain polyunsaturated fatty acids to extremely preterm infants associates with development of the intestinal microbiota.Pediatric research · 2026Article
- The development of residential gut microbiota in mice at different phases in early life.iScience · 2026Article
- The Gut Microbiome and Metabolome of Domestic Cats Were Altered by the Oral Administration of Complex Probiotics.Biology · 2026Article
- Causal relationship between gut microbiome and childhood allergy: A bidirectional Mendelian randomization analysis.Medicine · 2026Article
- Antibiotics in the first week of life and the association with atopic diseases at ages 9-12: a prospective cohort study.European journal of pediatrics · 2026Article
- Preparation of ESAT6-Fc Fusion Protein and Its Therapeutic Efficacy and Immune Mechanisms in Allergic Asthma Mice via Intranasal Immunization.Molecules (Basel, Switzerland) · 2025Article
- Review
- Association of intestinal barrier impairment with symptom severity and washed microbiota transplantation outcomes in atopic dermatitis patients.Frontiers in allergy · 2025Article
- Role of the microbiota-gut-lung axis in the pathogenesis of pulmonary disease in children and novel therapeutic strategies.Frontiers in immunology · 2025Review
- An insight into the gut microbiota of healthy and allergic West Highland Whiter Terrier dogs.PloS one · 2025Article
- Early-life gut microbiome development and its potential long-term impact on health outcomes.Microbiome research reports · 2025Review
- An evaluation of in utero polycyclic aromatic hydrocarbon exposure on the neonatal meconium microbiome.Environmental research · 2024Article
- Immunoglobulin-coating patterns reveal altered humoral responses to gut bacteria in pediatric cow milk allergies.Journal of translational medicine · 2024Article
- Relationship between infant gastrointestinal microorganisms and maternal microbiome within 6 months of delivery.Microbiology spectrum · 2024Article
- Article
- The Skin Histopathology of Pro- and Parabiotics in a Mouse Model of Atopic Dermatitis.Nutrients · 2024Article
- Emerging trends and future challenges of advanced 2D nanomaterials for combating bacterial resistance.Bioactive materials · 2024Review
- Characteristics of gut microbiota and serum metabolism in patients with atopic dermatitis.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2024Article
22 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Among the many areas being revolutionized by the recent introduction of culture-independent microbial identification techniques is investigation of the relationship between close contact with large animals, antibiotics, breast feeding, mode of birth, and other exposures during infancy as related to a reduced risk of asthma and allergic disease. These exposures were originally clustered under the "Hygiene Hypothesis" which has evolved into the "Microbiota Hypothesis". This review begins by summarizing epidemiologic studies suggesting that the common feature of these allergy risk-related exposures is their influence on the founding and early development of a child's gut microbiota. Next, studies using culture-independent techniques are presented showing that children who have experienced the exposures of interest have altered gut microbiota. Finally, selected mouse and human studies are presented which begin to corroborate the protective exposures identified in epidemiologic studies by elucidating mechanisms through which microbes can alter immune development and function. These microbially driven immune alterations demonstrate that microbial exposures in many cases could alter the risk of subsequent allergic disease and asthma. Hopefully, a better understanding of how microbes influence allergic disease will lead to safe and effective methods for reducing the prevalence of all forms of allergic disease.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.