Evidence map›Paper›PMID 27469242›Full record

Trial reportExperimental brain research2016

Placebo-controlled study of rTMS combined with Lokomat

Hatice Kumru, Jesus Benito-Penalva, Josep Valls-Sole, Narda Murillo, Josep M Tormos, Cecilia Flores, Joan Vidal

3 registry-linked trialsOpen access · greenAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Experimental brain research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 43 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 10 pooled it
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04807764 nacompletednot on this mapstarted 2021, after this paper: background citation

Priming With High-Frequency Trans-spinal Stimulation to Augment Locomotor Benefits in Spinal Cord Injury

TypeinterventionalSponsorCity University of New YorkRan2021 to 2024Enrolled14ConditionsSpinal Cord Injuries, Paraplegia, Spinal, Tetraplegia/Tetraparesis, Paraplegia, SpasticArmsStanding transspinal stimulation followed by robotic gait training, Lying transspinal stimulation followed by robotic gait training, Standing sham transspinal stimulation followed by robotic gait training
NCT04965727 naunknown statusnot on this mapstarted 2021, after this paper: background citation

Deep Brain Stimulation of the Lateral Hypothalamus to Augment Motor Function of Patients With Spinal Cord Injury

TypeinterventionalSponsorJocelyne BlochRan2021 to 2026Enrolled3ConditionsDeep Brain Stimulation, Neuro: Spinal Cord InjuryArmsDevice implantation
NCT05975606 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Exploring the Effect of Non-invasive Brain Stimulation Paired With Functional Electrical Stimulation to Improve Lower Extremity Function Following Incomplete Spinal Cord Injury

TypeinterventionalSponsorWestern University, CanadaRan2023 to 2025Enrolled14ConditionsIncomplete Spinal Cord InjuryArmsrepetitive transcranial magnetic stimulation (rTMS), functional electrical stimulation (FES) cycling
3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 10 syntheses or guidelines pooled it, 105 citations in OpenAlex.

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  17. Effects of repetitive transcranial magnetic stimulation on motor ability, neurophysiological changes, mental health, and activities of daily living in spinal cord injury: a systematic review and meta-analysis.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Hatice KumruHospital de Neurorehabilitació, Institut Universitari de Neurorehabilitació adscrit a la UAB, Fundación Institut Guttmann, Camí Can Ruti s/n, 08916, Badalona, Barcelona, Spain. hkumru@guttmann.com.
Jesus Benito-PenalvaHospital de Neurorehabilitació, Institut Universitari de Neurorehabilitació adscrit a la UAB, Fundación Institut Guttmann, Camí Can Ruti s/n, 08916, Badalona, Barcelona, Spain.
Josep Valls-SoleEMG unit, Neurology, Hospital Clinic-Barcelona, Barcelona, Spain.
Narda MurilloHospital de Neurorehabilitació, Institut Universitari de Neurorehabilitació adscrit a la UAB, Fundación Institut Guttmann, Camí Can Ruti s/n, 08916, Badalona, Barcelona, Spain.
Josep M TormosHospital de Neurorehabilitació, Institut Universitari de Neurorehabilitació adscrit a la UAB, Fundación Institut Guttmann, Camí Can Ruti s/n, 08916, Badalona, Barcelona, Spain.
Cecilia FloresHospital de Neurorehabilitació, Institut Universitari de Neurorehabilitació adscrit a la UAB, Fundación Institut Guttmann, Camí Can Ruti s/n, 08916, Badalona, Barcelona, Spain.
Joan VidalHospital de Neurorehabilitació, Institut Universitari de Neurorehabilitació adscrit a la UAB, Fundación Institut Guttmann, Camí Can Ruti s/n, 08916, Badalona, Barcelona, Spain.
Universitat Autònoma de Barcelona · ESInstitut d'Investigació en Ciències de la Salut Germans Trias i Pujol · ESHospital Clínic de Barcelona · ESInstitut Guttmann · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

High-frequency rTMS combined with gait training improves lower extremity motor score (LEMS) and gait velocity in SCI subjects who are able to walk over ground. The aim of this study was to optimize the functional outcome in early phases of gait rehabilitation in SCI using rTMS as an additional treatment to physical therapy. The present study included 31 motor incomplete SCI subjects randomized to receive real or sham rTMS, just before Lokomat gait training (15 subjects for real, 16 for sham rTMS). rTMS consisted of one daily session for 20 days over vertex (at 20 Hz). The subjects were evaluated using modified Ashworth scale (MAS) for spasticity, upper and lower extremity motor score (UEMS and LEMS, respectively), ten meters walking test (10MWT) and Walking Index for SCI (WISCI-II) for gait at baseline, after last rTMS session, and during follow-up. UEMS and LEMS improved significantly after last session in both groups and during follow-up period. The improvement was greater in real than in sham rTMS group. At follow-up, 71.4 % of the subjects after real rTMS and 40 % of the subjects after sham rTMS could perform 10MWT without significant differences in gait velocity, cadence, step length and WISCI-II between both groups. We conclude that 20 sessions of daily high-frequency rTMS combined with Lokomat gait training can lead to clinical improvement of gait in motor incomplete SCI. Such combined treatment improved motor strength in lower extremity in incomplete SCI subjects and in upper extremity in those with cervical SCI.

Indexed as

AdultAgedDisability EvaluationDouble-Blind MethodExercise TherapyFemaleFollow-Up StudiesGaitHumansMaleMiddle AgedMovement DisordersSpinal Cord InjuriesTranscranial Magnetic StimulationYoung AdultGait trainingLokomatrTMSSCIUpper extremity

Identifiers

PMID27469242
OpenAlexW2479125984

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.