Evidence map›Paper›PMID 27469179›Full record

ReviewPediatric clinics of North America2016

Cystic Fibrosis: Microbiology and Host Response.

Edith T Zemanick, Lucas R Hoffman

Abstract readReview
In one paragraph

Review in Pediatric clinics of North America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 44 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. ChronicInternational journal of molecular sciences · 2025
    Article
  5. Review
  6. Article
  7. IntracellularAmerican journal of respiratory and critical care medicine · 2024
    Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Review
  15. European respiratory review : an official journal of the European Respiratory Society · 2021
    Review
  16. Article
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Edith T ZemanickChildren's Hospital Colorado, University of Colorado School of Medicine, 13123 East 16th Avenue, B-395, Aurora, CO 80045, USA.
Lucas R HoffmanDepartments of Pediatrics and Microbiology, Seattle Children's Hospital and University of Washington, 4800 Sand Point Way Northeast, MS OC.7.720, Seattle, WA 98105, USA. Electronic address: lhoffm@uw.edu.
Seattle Children's Hospital · USUniversity of Colorado Denver · US

Funding

Translational Research Center to Expedite Novel Therapies in Cystic FibrosisP30DK089507 · NIDDK · SEATTLE CHILDREN'S HOSPITAL · PI Christopher Hooper Goss · 2010 to 2026
$21.4M
The relationship of fecal microbiomes and nutritional status in CFR01DK095869 · NIDDK · UNIVERSITY OF WASHINGTON · PI HOFFMAN, LUCAS R, MILLER, SAMUEL I · 2014 to 2018
$3.2M
Pseudomonas aeruginosa Adaptation During Early CF Airway Infection and TreatmentR01HL098084 · NHLBI · UNIVERSITY OF WASHINGTON · PI HOFFMAN, LUCAS R · 2009 to 2012
$1.6M
Airway Microbiome in Cystic Fibrosis Pulmonary ExacerbationsK23HL114883 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI ZEMANICK, EDITH TOWLER · 2014 to 2017
$615k
NHLBI NIH HHS K23 HL114883NHLBI NIH HHS R01 HL098084NIDDK NIH HHS P30 DK089507NIDDK NIH HHS R01 DK095869
6 · The paper itself

Abstract

The earliest descriptions of lung disease in people with cystic fibrosis (CF) showed the involvement of 3 interacting pathophysiologic elements in CF airways: mucus obstruction, inflammation, and infection. Over the past 7 decades, our understanding of CF respiratory microbiology and inflammation has evolved with the introduction of new treatments, increased longevity, and increasingly sophisticated laboratory techniques. This article reviews the current understanding of infection and inflammation and their roles in CF lung disease. It also discusses how this constantly evolving information is used to inform current therapeutic strategies, measures and predictors of disease severity, and research priorities.

Indexed as

Anti-Bacterial AgentsCystic FibrosisHumansInflammationLung DiseasesRespiratory Tract InfectionsAnti-Bacterial AgentsBiomarkerCystic fibrosisInfectionInflammationMicrobiologyNeutrophil

Identifiers

PMID27469179
PMCPMC4967239
OpenAlexW2499384900

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.