Evidence map›Paper›PMID 27469166›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2016

FAR-RED ELONGATED HYPOCOTYL3 activates SEPALLATA2 but inhibits CLAVATA3 to regulate meristem determinacy and maintenance in Arabidopsis.

Dongming Li, Xing Fu, Lin Guo, Zhigang Huang, Yongpeng Li, Yang Liu, Zishan He, Xiuwei Cao, Xiaohan Ma, Meicheng Zhao and 6 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
6.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 57 citations in OpenAlex.

  1. ThePlants (Basel, Switzerland) · 2026
    Review
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  17. PeerJ · 2022
    Article
  18. Robust control of floral meristem determinacy by position-specific multifunctions of KNUCKLES.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 2 countries.

Dongming LiState Key Laboratory of Plant Cell and Chromosome Engineering, Center for Agricultural Resources Research, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Shijiazhuang 050021, China; Hebei Collaboration Innovation Center for Cell Signaling, College of Life Sciences, Hebei Normal University, Shijiazhuang 050024, China; School of Life Sciences, Lanzhou University, Lanzhou 730000, China;
Xing FuShanghai Center for Plant Stress Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201602, China;
Lin GuoState Key Laboratory of Plant Cell and Chromosome Engineering, Center for Agricultural Resources Research, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Shijiazhuang 050021, China; Hebei Collaboration Innovation Center for Cell Signaling, College of Life Sciences, Hebei Normal University, Shijiazhuang 050024, China;
Zhigang HuangDepartment of Botany and Plant Sciences, Institute of Integrative Genome Biology, University of California, Riverside, CA 92521; Hunan Provincial Key Laboratory of Phytohormones and Growth Development, Hunan Agricultural University, Changsha 410128, Hunan, China;
Yongpeng LiState Key Laboratory of Plant Cell and Chromosome Engineering, Center for Agricultural Resources Research, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Shijiazhuang 050021, China; Hebei Collaboration Innovation Center for Cell Signaling, College of Life Sciences, Hebei Normal University, Shijiazhuang 050024, China; College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China;
Yang LiuBiotechnology Research Institute, Chinese Academy of Agricultural Sciences, Beijing 100081, China;
Zishan HeState Key Laboratory of Plant Cell and Chromosome Engineering, Center for Agricultural Resources Research, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Shijiazhuang 050021, China; Hebei Collaboration Innovation Center for Cell Signaling, College of Life Sciences, Hebei Normal University, Shijiazhuang 050024, China; College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China;
Xiuwei CaoState Key Laboratory of Plant Cell and Chromosome Engineering, Center for Agricultural Resources Research, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Shijiazhuang 050021, China; Hebei Collaboration Innovation Center for Cell Signaling, College of Life Sciences, Hebei Normal University, Shijiazhuang 050024, China; College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China;
Xiaohan MaState Key Laboratory of Plant Cell and Chromosome Engineering, Center for Agricultural Resources Research, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Shijiazhuang 050021, China; College of Life Sciences, South China Agricultural University, Guangzhou 510642, China;
Meicheng ZhaoState Key Laboratory of Plant Cell and Chromosome Engineering, Center for Agricultural Resources Research, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Shijiazhuang 050021, China; Hebei Collaboration Innovation Center for Cell Signaling, College of Life Sciences, Hebei Normal University, Shijiazhuang 050024, China;
Guohui ZhuCollege of Life Sciences, South China Agricultural University, Guangzhou 510642, China;
Langtao XiaoHunan Provincial Key Laboratory of Phytohormones and Growth Development, Hunan Agricultural University, Changsha 410128, Hunan, China;
Haiyang WangBiotechnology Research Institute, Chinese Academy of Agricultural Sciences, Beijing 100081, China;
Xuemei ChenDepartment of Botany and Plant Sciences, Institute of Integrative Genome Biology, University of California, Riverside, CA 92521; Howard Hughes Medical Institute, University of California, Riverside, CA 92521.
Renyi LiuShanghai Center for Plant Stress Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201602, China; ryliu@sibs.ac.cn xgliu@sjziam.ac.cn.
Xigang LiuState Key Laboratory of Plant Cell and Chromosome Engineering, Center for Agricultural Resources Research, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Shijiazhuang 050021, China; Hebei Collaboration Innovation Center for Cell Signaling, College of Life Sciences, Hebei Normal University, Shijiazhuang 050024, China; ryliu@sibs.ac.cn xgliu@sjziam.ac.cn.ORCID 0000-0003-4473-2900
Chinese Academy of Sciences · CNChinese Academy of Agricultural Sciences · CNSouth China Agricultural University · CNUniversity of California, Riverside · USHunan Agricultural University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Plant meristems are responsible for the generation of all plant tissues and organs. Here we show that the transcription factor (TF) FAR-RED ELONGATED HYPOCOTYL3 (FHY3) plays an important role in both floral meristem (FM) determinacy and shoot apical meristem maintenance in Arabidopsis, in addition to its well-known multifaceted roles in plant growth and development during the vegetative stage. Through genetic analyses, we show that WUSCHEL (WUS) and CLAVATA3 (CLV3), two central players in the establishment and maintenance of meristems, are epistatic to FHY3 Using genome-wide ChIP-seq and RNA-seq data, we identify hundreds of FHY3 target genes in flowers and find that FHY3 mainly acts as a transcriptional repressor in flower development, in contrast to its transcriptional activator role in seedlings. Binding motif-enrichment analyses indicate that FHY3 may coregulate flower development with three flower-specific MADS-domain TFs and four basic helix-loop-helix TFs that are involved in photomorphogenesis. We further demonstrate that CLV3, SEPALLATA1 (SEP1), and SEP2 are FHY3 target genes. In shoot apical meristem, FHY3 directly represses CLV3, which consequently regulates WUS to maintain the stem cell pool. Intriguingly, CLV3 expression did not change significantly in fhy3 and phytochrome B mutants before and after light treatment, indicating that FHY3 and phytochrome B are involved in light-regulated meristem activity. In FM, FHY3 directly represses CLV3, but activates SEP2, to ultimately promote FM determinacy. Taken together, our results reveal insights into the mechanisms of meristem maintenance and determinacy, and illustrate how the roles of a single TF may vary in different organs and developmental stages.

Indexed as

ArabidopsisArabidopsis ProteinsFlowersHomeodomain ProteinsMeristemPhytochromeTranscription FactorsArabidopsis ProteinsAT2G27250 protein, ArabidopsisFHY3 protein, ArabidopsisHomeodomain ProteinsPhytochromeSEPALLATA protein, ArabidopsisTranscription FactorsWUSCHEL protein, ArabidopsisCLV3FHY3meristem determinacymeristem maintenanceSEP2

Identifiers

PMID27469166
PMCPMC4995929
OpenAlexW2482876003

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.