ArticleProceedings of the National Academy of Sciences of the United States of America2016
Neural mechanisms of transient neocortical beta rhythms: Converging evidence from humans, computational modeling, monkeys, and mice.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04062318 (The Causal Role of Neocortical Beta Events in Human Sensory Perception), which is not on this map. Cited by 250 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Causal Role of Neocortical Beta Events in Human Sensory Perception
Who cites it
250 citing papers in PubMed.
- Transient frontal spectral events from EEG predict antidepressant response to sertraline in depression.Journal of psychiatric research · 2026Trial
- Neurofeedback-Linked Suppression of Cortical β Bursts Speeds Up Movement Initiation in Healthy Motor Control: A Double-Blind Sham-Controlled Study.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Trial
- Frequency-Specific EEG burst dynamics in Parkinson's Disease and freezing of gait.Journal of neurology · 2026Article
- Higher cortical beta oscillatory power before balance perturbations is associated with worse balance in older adults with Parkinson's Disease, but not in age-matched older adults.bioRxiv : the preprint server for biology · 2026Article
- Article
- Mental tasks induce common modulations of oscillations in cortex and spinal cord.Journal of neuroengineering and rehabilitation · 2026Article
- The alpha rhythm: from physiology to behavior.Physiological reviews · 2026Review
- Distinct goal location beta frequency dynamics in hippocampus and prefrontal cortex across learning.bioRxiv : the preprint server for biology · 2026Article
- Distinct temporal patterns of beta bursts differentiate successful and failed movement cancellation.iScience · 2026Article
- Universal rhythmic architecture uncovers two modes of neural dynamics.Nature communications · 2026Article
- Oscillatory Markers of Interoceptive Attention: Beta Suppression as a Neural Signature of Heartbeat Processing.Psychophysiology · 2026Article
- Olfactory bulb-cortex oscillations encode perceived odor intensity rather than concentration.PLoS biology · 2026Article
- Article
- Uncovering putative neural mechanisms of neurotherapeutic impacts on EEG using the Human Neocortical Neurosolver.bioRxiv : the preprint server for biology · 2026Article
- Instability of Alpha Oscillatory States in Autism and Familial Liability: Evidence from Burst-Resolved High-Density Electroencephalography (EEG).bioRxiv : the preprint server for biology · 2026Article
- Article
- β-Bursting as a Sensitive Neural Marker of Inhibitory Control in Healthy Older Adults: A Linear Mixed-Effects Modeling and Threshold-Free Cluster Approach.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- A Spatially Structured Spiking Network Model of Beta Traveling Waves and Their Attenuation in Motor Cortex.bioRxiv : the preprint server for biology · 2026Article
- Alpha and Beta Corticomotor Phase Dynamics Shape Visuomotor Control on a Single-Trial Basis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Mapping Executive Function Performance Based on Resting-State EEG in Healthy Individuals: A Systematic and Mechanistic Review.Journal of clinical medicine · 2026Review
190 more citing papers are in PubMed but not listed here.
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Authors and funding
8 authors.
Funding
Abstract
Human neocortical 15-29-Hz beta oscillations are strong predictors of perceptual and motor performance. However, the mechanistic origin of beta in vivo is unknown, hindering understanding of its functional role. Combining human magnetoencephalography (MEG), computational modeling, and laminar recordings in animals, we present a new theory that accounts for the origin of spontaneous neocortical beta. In our MEG data, spontaneous beta activity from somatosensory and frontal cortex emerged as noncontinuous beta events typically lasting <150 ms with a stereotypical waveform. Computational modeling uniquely designed to infer the electrical currents underlying these signals showed that beta events could emerge from the integration of nearly synchronous bursts of excitatory synaptic drive targeting proximal and distal dendrites of pyramidal neurons, where the defining feature of a beta event was a strong distal drive that lasted one beta period (∼50 ms). This beta mechanism rigorously accounted for the beta event profiles; several other mechanisms did not. The spatial location of synaptic drive in the model to supragranular and infragranular layers was critical to the emergence of beta events and led to the prediction that beta events should be associated with a specific laminar current profile. Laminar recordings in somatosensory neocortex from anesthetized mice and awake monkeys supported these predictions, suggesting this beta mechanism is conserved across species and recording modalities. These findings make several predictions about optimal states for perceptual and motor performance and guide causal interventions to modulate beta for optimal function.
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Registered trials
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