ArticleJournal of the American Heart Association2016
Ambient Air Pollution Is Associated With the Severity of Coronary Atherosclerosis and Incident Myocardial Infarction in Patients Undergoing Elective Cardiac Evaluation.
Article in Journal of the American Heart Association, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 6 syntheses or guidelines pooled it, 69 citations in OpenAlex.
- Ambient fine particulate matter of diameter ≤ 2.5 μm and risk of hemorrhagic stroke: a systemic review and meta-analysis of cohort studies.Environmental science and pollution research international · 2021Pooled it
- Long-Term PMJournal of the American Heart Association · 2021Pooled it
- Long-Term Exposure to Ambient Air Pollution and Myocardial Infarction: A Systematic Review and Meta-Analysis.Frontiers in medicine · 2021Pooled it
- Long-term exposure to NOEnvironment international · 2020Pooled it
- Characteristics of cohort studies of long-term exposure to PMEnvironmental science and pollution research international · 2019Pooled it
- Association between maternal exposure to pollutant particulate matter 2.5 and congenital heart defects: a systematic review.JBI database of systematic reviews and implementation reports · 2019Pooled it
- Long-term exposure to wildfire smoke particulate matter and incident stroke: a US nationwide study.European heart journal · 2026Article
- The Dark Triad of Particulate Matter, Oxidative Stress and Coronary Artery Disease: What About the Antioxidant Therapeutic Potential.Antioxidants (Basel, Switzerland) · 2025Review
- Associations between air pollution and hospitalization for cardiovascular disease: a time series study in Nanchong.Frontiers in public health · 2025Article
- Effect modification by statin use status on the association between fine particulate matter (PM2.5) and cardiovascular mortality.International journal of epidemiology · 2024Article
- Long-term exposure to air pollution on cardio-respiratory, and lung cancer mortality: a systematic review and meta-analysis.Journal of environmental health science & engineering · 2024Review
- Clearing the Air to Address Pollution's Cardiovascular Health Crisis.Global heart · 2024Article
- Long-Term Exposure to Ambient PMJournal of the American Heart Association · 2023Article
- Effects of low-level air pollution exposures on hospital admission for myocardial infarction using multiple causal models.Environmental research · 2023Article
- Air Pollution, Built Environment, and Early Cardiovascular Disease.Circulation research · 2023Review
- The macrophage senescence hypothesis: the role of poor heat shock response in pulmonary inflammation and endothelial dysfunction following chronic exposure to air pollution.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2022Review
- Climate change and the prevention of cardiovascular disease.American journal of preventive cardiology · 2022Review
- The cardiovascular effects of air pollution: Prevention and reversal by pharmacological agents.Pharmacology & therapeutics · 2022Review
- Analysis of long- and medium-term particulate matter exposures and stroke in the US-based Health Professionals Follow-up Study.Environmental epidemiology (Philadelphia, Pa.) · 2021Article
- Adipose-derived stem cells therapy effectively attenuates PMStem cell research & therapy · 2021Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundThe effect of air pollution exposure on atherosclerosis severity or incident clinical events in patients with coronary artery disease is not known. METHODS AND
resultsWe conducted a prospective longitudinal cohort study of 6575 Ohio residents undergoing elective diagnostic coronary angiography. Multinomial regression and Cox proportional hazards models were used to assess the relationship between exposure to fine particulate matter <2.5 μm in diameter (PM2.5) and nitrogen dioxide on coronary artery disease severity at baseline and risk of myocardial infarction, stroke, or all-cause mortality over 3 years of follow-up. Among participants with coronary artery disease, exposure to PM2.5 levels was associated with increased likelihood of having coronary atherosclerosis that was mild (odds ratio 1.43, 95% CI 1.11-1.83, P=0.005) and severe (odds ratio 1.63, 95% CI 1.26-2.11, P<0.0001), with the effect on severe coronary artery disease being significantly increased compared with mild disease (Ptrend=0.03). Exposure to higher PM2.5 levels was also significantly associated with increased risk of incident myocardial infarction (hazard ratio 1.33, 95% CI 1.02-1.73, P=0.03) but not stroke or all-cause mortality. The association of PM2.5 with incident myocardial infarction was not affected after adjustment for Framingham Adult Treatment Panel III (ATP III) risk score or statin therapy. In comparison, there were no significant associations between nitrogen dioxide levels and all-cause mortality or risk of stroke after adjustment for Framingham ATP III risk score.
conclusionsExposure to PM2.5 increased the likelihood of having severe coronary artery disease and the risk of incident myocardial infarction among patients undergoing elective cardiac evaluation. These results suggest that ambient air pollution exposure may be a modifiable risk factor for risk of myocardial infarction in a highly susceptible patient population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.