ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2017
Response of the Tail of the Ventral Tegmental Area to Aversive Stimuli.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 55 citations in OpenAlex.
- Nociceptive responses and resting-state functional connectivity of the human midbrain tegmentum.Brain structure & function · 2026Article
- Morphine regulates astrocyte transcriptional dynamics in the ventral tegmental area by stimulation of glucocorticoid signaling.bioRxiv : the preprint server for biology · 2025Article
- Activation of the tail of the ventral tegmental area in response to pup predicting cues in maternal rats.Brain structure & function · 2025Article
- Substantia Nigra Dopamine Neuronal Responses to Habenular Stimulation and Foot Shock Are Altered by Lesions of the Rostromedial Tegmental Nucleus.Neuroscience · 2024Article
- The rostromedial tegmental nucleus RMTg is not a critical site for ethanol-induced motor activation in rats.Psychopharmacology · 2023Article
- Rostromedial tegmental nucleus nociceptin/orphanin FQ (N/OFQ) signaling regulates anxiety- and depression-like behaviors in alcohol withdrawn rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- Neural mechanism of acute stress regulation by trace aminergic signalling in the lateral habenula in male mice.Nature communications · 2023Article
- Integrative Roles of Dopamine Pathway and Calcium Channels Reveal a Link between Schizophrenia and Opioid Use Disorder.International journal of molecular sciences · 2023Article
- The rostromedial tegmental (RMTg) "brake" on dopamine and behavior: A decade of progress but also much unfinished work.Neuropharmacology · 2021Review
- Synaptic Adaptations at the Rostromedial Tegmental Nucleus Underlie Individual Differences in Cocaine Avoidance Behavior.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Live predator stress in adolescence results in distinct adult behavioral consequences and dorsal diencephalic brain activation patterns.Behavioural brain research · 2021Article
- Article
- Progress in opioid reward research: From a canonical two-neuron hypothesis to two neural circuits.Pharmacology, biochemistry, and behavior · 2021Review
- Circuits and functions of the lateral habenula in health and in disease.Nature reviews. Neuroscience · 2020Review
- Sex differences in the expression of morphine withdrawal symptoms and associated activity in the tail of the ventral tegmental area.Neuroscience letters · 2019Article
- Alcohol withdrawal drives depressive behaviors by activating neurons in the rostromedial tegmental nucleus.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Article
- Article
- Gene expression and neurochemical characterization of the rostromedial tegmental nucleus (RMTg) in rats and mice.Brain structure & function · 2019Article
- Inhibitory Plasticity of Mesocorticolimbic Circuits in Addiction and Mental Illness.Trends in neurosciences · 2018Review
- Diminished positive affect and traumatic stress: A biobehavioral review and commentary on trauma affective neuroscience.Neurobiology of stress · 2018Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The GABAergic tail of the ventral tegmental area (tVTA), also named rostromedial tegmental nucleus (RMTg), exerts an inhibitory control on dopamine neurons of the VTA and substantia nigra. The tVTA has been implicated in avoidance behaviors, response to drugs of abuse, reward prediction error, and motor functions. Stimulation of the lateral habenula (LHb) inputs to the tVTA, or of the tVTA itself, induces avoidance behaviors, which suggests a role of the tVTA in processing aversive information. Our aim was to test the impact of aversive stimuli on the molecular recruitment of the tVTA, and the behavioral consequences of tVTA lesions. In rats, we assessed Fos response to lithium chloride (LiCl), β-carboline, naloxone, lipopolysaccharide (LPS), inflammatory pain, neuropathic pain, foot-shock, restraint stress, forced swimming, predator odor, and opiate withdrawal. We also determined the effect of tVTA bilateral ablation on physical signs of opiate withdrawal, and on LPS- and LiCl-induced conditioned taste aversion (CTA). Naloxone-precipitated opiate withdrawal induced Fos in μ-opioid receptor-positive (15%) and -negative (85%) tVTA cells, suggesting the presence of both direct and indirect mechanisms in tVTA recruitment during withdrawal. However, tVTA lesion did not impact physical signs of opiate withdrawal. Fos induction was also present with repeated, but not single, foot-shock delivery. However, such induction was mostly absent with other aversive stimuli. Moreover, tVTA ablation had no impact on CTA. Although stimulation of the tVTA favors avoidance behaviors, present findings suggest that this structure may be important to the response to some, but not all, aversive stimuli.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.