ArticleScientific reports2016
Self-assembled monolayers of alendronate on Ti6Al4V alloy surfaces enhance osteogenesis in mesenchymal stem cells.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 33 citations in OpenAlex.
- Alendronate as Bioactive Coating on Titanium Surfaces: An Investigation of CaP-Alendronate Interactions.Materials (Basel, Switzerland) · 2024Article
- Surface Functionalisation of Dental Implants with a Composite Coating of Alendronate and Hydrolysed Collagen: DFT and EIS Studies.Materials (Basel, Switzerland) · 2022Article
- Streamlined Fabrication of Hybrid Lipid Bilayer Membranes on Titanium Oxide Surfaces: A Comparison of One- and Two-Tail SAM Molecules.Nanomaterials (Basel, Switzerland) · 2022Article
- Regulation of extracellular bioactive cations in bone tissue microenvironment induces favorable osteoimmune conditions to accelerateBioactive materials · 2021Article
- Properties improvement of titanium alloys scaffolds in bone tissue engineering: a literature review.Annals of translational medicine · 2021Review
- New details of assembling bioactive films from dispersions of amphiphilic molecules on titania surfaces.RSC advances · 2020Article
- A New Insight into Coating's Formation Mechanism Between TiOMaterials (Basel, Switzerland) · 2020Article
- Achievements in the Topographic Design of Commercial Titanium Dental Implants: Towards Anti-Peri-Implantitis Surfaces.Journal of clinical medicine · 2019Review
- Novel Bioactive and Antibacterial Acrylic Bone Cement Nanocomposites Modified with Graphene Oxide and Chitosan.International journal of molecular sciences · 2019Article
- Tissue Engineering Therapies Based on Folic Acid and Other Vitamin B Derivatives. Functional Mechanisms and Current Applications in Regenerative Medicine.International journal of molecular sciences · 2018Review
- Self-Assembled Monolayers for Dental Implants.International journal of dentistry · 2018Review
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Authors and funding
5 authors at 3 institutions in 1 country.
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Abstract
Phosphonates have emerged as an alternative for functionalization of titanium surfaces by the formation of homogeneous self-assembled monolayers (SAMs) via Ti-O-P linkages. This study presents results from an investigation of the modification of Ti6Al4V alloy by chemisorption of osseoinductive alendronate using a simple, effective and clean methodology. The modified surfaces showed a tailored topography and surface chemistry as determined by SEM microscopy and RAMAN spectroscopy. X-ray photoelectron spectroscopy revealed that an effective mode of bonding is created between the metal oxide surface and the phosphate residue of alendronate, leading to formation of homogenous drug distribution along the surface. In-vitro studies showed that alendronate SAMs induce differentiation of hMSC to a bone cell phenotype and promote bone formation on modified surfaces. Here we show that this novel method for the preparation of functional coatings on titanium-based medical devices provides osseoinductive bioactive molecules to promote enhanced integration at the site of implantation.
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