Evidence map›Paper›PMID 27468708›Full record

Trial reportDiabetologia2016

Oral AGE restriction ameliorates insulin resistance in obese individuals with the metabolic syndrome: a randomised controlled trial.

Helen Vlassara, Weijing Cai, Elizabeth Tripp, Renata Pyzik, Kalle Yee, Laurie Goldberg, Laurie Tansman, Xue Chen, Venkatesh Mani, Zahi A Fayad and 4 more

Registry-linked trialOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Diabetologia, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01363141 (Effects of Glycooxidative Stress on Human Aging- Study #3), which is not on this map. Cited by 72 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed, 4 pooled it
9.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01363141 nacompletednot on this map

Effects of Glycooxidative Stress on Human Aging- Study #3

TypeinterventionalSponsorIcahn School of Medicine at Mount SinaiRan2010 to 2014Enrolled383ConditionsMetabolic SyndromeArmsRegular AGE Diet, Low AGE Diet
3 · Its place in the literature

Who cites it

72 citing papers in PubMed, 4 syntheses or guidelines pooled it, 139 citations in OpenAlex.

  1. Pooled it
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  11. Dietary Advanced Glycation End Products and Cardiovascular-Kidney-Metabolic Complications.Clinical journal of the American Society of Nephrology : CJASN · 2026
    Review
  12. Observational
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  19. Chilean papaya (Heliyon · 2024
    Article
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12 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Helen VlassaraDepartment of Geriatrics, Division of Experimental Diabetes and Aging, The Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY, 10029, USA.
Weijing CaiDepartment of Geriatrics, Division of Experimental Diabetes and Aging, The Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY, 10029, USA.
Elizabeth TrippDepartment of Geriatrics, Division of Experimental Diabetes and Aging, The Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY, 10029, USA.
Renata PyzikDepartment of Geriatrics, Division of Experimental Diabetes and Aging, The Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY, 10029, USA.
Kalle YeeDepartment of Geriatrics, Division of Experimental Diabetes and Aging, The Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY, 10029, USA.
Laurie GoldbergDepartment of Geriatrics, Division of Experimental Diabetes and Aging, The Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY, 10029, USA.
Laurie TansmanDepartment of Geriatrics, Division of Experimental Diabetes and Aging, The Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY, 10029, USA.
Xue ChenDepartment of Geriatrics, Division of Experimental Diabetes and Aging, The Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY, 10029, USA.
Venkatesh ManiTranslational and Molecular Imaging Institute, The Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Zahi A FayadTranslational and Molecular Imaging Institute, The Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Girish N NadkarniDepartment of Medicine, Division of Nephrology, The Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Gary E StrikerDepartment of Geriatrics, Division of Experimental Diabetes and Aging, The Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY, 10029, USA.
John C HeDepartment of Medicine, Division of Nephrology, The Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Jaime UribarriDepartment of Medicine, Division of Nephrology, The Icahn School of Medicine at Mount Sinai, New York, NY, USA. Jaime.uribarri@mssm.edu.
Icahn School of Medicine at Mount Sinai · USImaging Center · US

Funding

ZIPRASIDONE (GEODON) AUGMENTATION IN SEROTONIN REUPTAKE INHIBITOR-RESISTANT OBM01RR000071 · NCRR · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI NEWCORN, JEFFREY H · 1985 to 2009
$41.5M
Effects of Glycoxidative Stress on Human AgingR01DK091231 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI HE, JOHN CIJIANG · 2010 to 2014
$3.1M
NCRR NIH HHS M01 RR000071NIDDK NIH HHS R01 DK091231
6 · The paper itself

Abstract

aims/hypothesisWe previously reported that obese individuals with the metabolic syndrome (at risk), compared with obese individuals without the metabolic syndrome (healthy obese), have elevated serum AGEs that strongly correlate with insulin resistance, oxidative stress and inflammation. We hypothesised that a diet low in AGEs (L-AGE) would improve components of the metabolic syndrome in obese individuals, confirming high AGEs as a new risk factor for the metabolic syndrome.

methodsA randomised 1 year trial was conducted in obese individuals with the metabolic syndrome in two parallel groups: L-AGE diet vs a regular diet, habitually high in AGEs (Reg-AGE). Participants were allocated to each group by randomisation using random permuted blocks. At baseline and at the end of the trial, we obtained anthropometric variables, blood and urine samples, and performed OGTTs and MRI measurements of visceral and subcutaneous abdominal tissue and carotid artery. Only investigators involved in laboratory determinations were blinded to dietary assignment. Effects on insulin resistance (HOMA-IR) were the primary outcome.

resultsSixty-one individuals were randomised to a Reg-AGE diet and 77 to an L-AGE diet; the data of 49 and 51, respectively, were analysed at the study end in 2014. The L-AGE diet markedly improved insulin resistance; modestly decreased body weight; lowered AGEs, oxidative stress and inflammation; and enhanced the protective factors sirtuin 1, AGE receptor 1 and glyoxalase I. The Reg-AGE diet raised AGEs and markers of insulin resistance, oxidative stress and inflammation. There were no effects on MRI-assessed measurements. No side effects from the intervention were identified. HOMA-IR came down from 3.1 ± 1.8 to 1.9 ± 1.3 (p < 0.001) in the L-AGE group, while it increased from 2.9 ± 1.2 to 3.6 ± 1.7 (p < 0.002) in the Reg-AGE group. CONCLUSIONS/

interpretationL-AGE ameliorates insulin resistance in obese people with the metabolic syndrome, and may reduce the risk of type 2 diabetes, without necessitating a major reduction in adiposity. Elevated serum AGEs may be used to diagnose and treat 'at-risk' obesity.

trial registrationClinicalTrials.gov NCT01363141

fundingThe study was funded by the National Institute of Diabetes and Digestive and Kidney Diseases (DK091231).

Indexed as

3T3-L1 CellsAgedAged, 80 and overAnimalsBlood GlucoseBlotting, WesternDiabetes Mellitus, Type 2FemaleGlycation End Products, AdvancedHumansInflammationInsulinInsulin ResistanceMaleMetabolic SyndromeMiceBlood GlucoseGlycation End Products, AdvancedInsulinAGER1Cardiovascular diseaseDiabetesGlycotoxinsInflammationInnate defenceRAGESIRT1

Identifiers

PMID27468708
PMCPMC5129175
OpenAlexW2479063120

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.