Evidence map›Paper›PMID 27468365›Full record

ArticleExperimental hematology & oncology2015

Complete remission after single agent blinatumomab in a patient with pre-B acute lymphoid leukemia relapsed and refractory to three prior regimens: hyperCVAD, high dose cytarabine mitoxantrone and CLAG.

Katherine Linder, Deepthi Gandhiraj, Madhura Hanmantgad, Karen Seiter, Delong Liu

Open access · goldAbstract readCase Reports
In one paragraph

Article in Experimental hematology & oncology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. New development in CAR-T cell therapy.Journal of hematology & oncology · 2017
    Review
  6. Article
  7. Review
  8. Second-generation inhibitors of Bruton tyrosine kinase.Journal of hematology & oncology · 2016
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Katherine LinderDepartment of Medicine, New York Medical College and Westchester Medical Center, Valhalla, NY 10595 USA.
Deepthi GandhirajDepartment of Medicine, New York Medical College and Westchester Medical Center, Valhalla, NY 10595 USA.
Madhura HanmantgadDepartment of Medicine, New York Medical College and Westchester Medical Center, Valhalla, NY 10595 USA.
Karen SeiterDepartment of Medicine, New York Medical College and Westchester Medical Center, Valhalla, NY 10595 USA.
Delong LiuDepartment of Medicine, New York Medical College and Westchester Medical Center, Valhalla, NY 10595 USA.
New York Medical College · USWestchester Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe current standard of care for relapsed and refractory acute lymphoblastic leukemia (ALL) is combination chemotherapy. CASE PRESENTATION: We report a case of highly refractory ALL who was treated with blinatumomab. The ALL in this patient relapsed within a month after completion of hyperCVAD regimen and was refractory to high dose mitoxantrone/cytarabine and CLAG regimens.

conclusionThis highly refractory pre-B Ph(-) ALL was induced to complete remission after one course of single agent blinatumomab.

Identifiers

PMID27468365
PMCPMC4962515
OpenAlexW2485045656

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.