ArticleFrontiers in psychiatry2016
Belief about Nicotine Modulates Subjective Craving and Insula Activity in Deprived Smokers.
Article in Frontiers in psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed.
- The impacts of actual and perceived nicotine administration on insula functional connectivity with the anterior cingulate cortex and nucleus accumbens.Journal of psychopharmacology (Oxford, England) · 2019Trial
- A computational mechanism linking momentary craving and decision-making in alcohol drinkers and cannabis users.Nature. Mental health · 2026Article
- The correlation between drug abuse belief, refusal of self-efficacy and drug craving of patients in the treatment of methadone replacement treatment.Frontiers in psychology · 2026Article
- Brain reactivity to nicotine cues mediates the link between resting-state connectivity and cue-induced craving in individuals who smoke or vape nicotine.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Nicotine-related beliefs induce dose-dependent responses in the human brain.Nature. Mental health · 2024Article
- Interoception Within the Context of Impulsivity and Addiction.Current addiction reports · 2023Review
- Effects of Smoking Status and State on Intrinsic Connectivity.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2022Article
- A methodological checklist for fMRI drug cue reactivity studies: development and expert consensus.Nature protocols · 2022Article
- Better living through understanding the insula: Why subregions can make all the difference.Neuropharmacology · 2021Review
- Computational theory-driven studies of reinforcement learning and decision-making in addiction: What have we learned?Current opinion in behavioral sciences · 2021Article
- Smoking-induced craving relief relates to increased DLPFC-striatal coupling in nicotine-dependent women.Drug and alcohol dependence · 2021Article
- An insula-driven network computes decision uncertainty and promotes abstinence in chronic cocaine users.The European journal of neuroscience · 2020Article
- Computational models of drug use and addiction: A review.Journal of abnormal psychology · 2020Review
- Effects of Framing Nicotine Reduction in Cigarettes on Anticipated Tobacco Product Use Intentions and Risk Perceptions Among US Adult Smokers.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2019Article
- The impact of nicotine dose and instructed dose on smokers' implicit attitudes to smoking cues: An ERP study.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2019Article
- Modeling subjective belief states in computational psychiatry: interoceptive inference as a candidate framework.Psychopharmacology · 2019Article
- The insula in nicotine use disorder: Functional neuroimaging and implications for neuromodulation.Neuroscience and biobehavioral reviews · 2019Review
- Neurofeedback and the Neural Representation of Self: Lessons From Awake State and Sleep.Frontiers in human neuroscience · 2018Article
- A Bayesian Observer Model of Drug Craving.JAMA psychiatry · 2017Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Little is known about the specific neural mechanisms through which cognitive factors influence craving and associated brain responses, despite the initial success of cognitive therapies in treating drug addiction. In this study, we investigated how cognitive factors such as beliefs influence subjective craving and neural activities in nicotine-addicted individuals using model-based functional magnetic resonance imaging (fMRI) and neuropharmacology. Deprived smokers (N = 24) participated in a two-by-two balanced placebo design, which crossed beliefs about nicotine (told "nicotine" vs. told "no nicotine") with the nicotine content in a cigarette (nicotine vs. placebo) which participants smoked immediately before performing a fMRI task involving reward learning. Subjects' reported craving was measured both before smoking and after the fMRI session. We found that first, in the presence of nicotine, smokers demonstrated significantly reduced craving after smoking when told "nicotine in cigarette" but showed no change in craving when told "no nicotine." Second, neural activity in the insular cortex related to craving was only significant when smokers were told "nicotine" but not when told "no nicotine." Both effects were absent in the placebo condition. Third, insula activation related to computational learning signals was modulated by belief about nicotine regardless of nicotine's presence. These results suggest that belief about nicotine has a strong impact on subjective craving and insula responses related to both craving and learning in deprived smokers, providing insights into the complex nature of belief-drug interactions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.