Evidence map›Paper›PMID 27468200›Full record

Observational studyWorld journal of gastroenterology2016

High circulating tumor cell concentrations in a specific subtype of gastric cancer with diffuse bone metastasis at diagnosis.

Kazuhiro Shimazu, Koji Fukuda, Taichi Yoshida, Masahiro Inoue, Hiroyuki Shibata

Open access · hybridAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in World journal of gastroenterology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.6field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Kazuhiro ShimazuKazuhiro Shimazu, Koji Fukuda, Taichi Yoshida, Masahiro Inoue, Hiroyuki Shibata, Department of Clinical Oncology, Graduate School of Medicine, Akita University, Akita 0108543, Japan.
Koji FukudaKazuhiro Shimazu, Koji Fukuda, Taichi Yoshida, Masahiro Inoue, Hiroyuki Shibata, Department of Clinical Oncology, Graduate School of Medicine, Akita University, Akita 0108543, Japan.
Taichi YoshidaKazuhiro Shimazu, Koji Fukuda, Taichi Yoshida, Masahiro Inoue, Hiroyuki Shibata, Department of Clinical Oncology, Graduate School of Medicine, Akita University, Akita 0108543, Japan.
Masahiro InoueKazuhiro Shimazu, Koji Fukuda, Taichi Yoshida, Masahiro Inoue, Hiroyuki Shibata, Department of Clinical Oncology, Graduate School of Medicine, Akita University, Akita 0108543, Japan.
Hiroyuki ShibataKazuhiro Shimazu, Koji Fukuda, Taichi Yoshida, Masahiro Inoue, Hiroyuki Shibata, Department of Clinical Oncology, Graduate School of Medicine, Akita University, Akita 0108543, Japan.
Akita University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo clarify the biological feature contributing to gastric cancer with diffuse bone metastases at diagnosis.

methodsThe participants visited the Department of Clinical Oncology, Akita University Hospital, from January 2014 to August 2015. The selection criterion for gastric cancer with diffuse bone metastases at diagnosis includes over 29 hot spots of bone scintigraphy. Circulating tumor cell were collected from 20 mL of peripheral venous blood drawn using a CellSearch kit and a CellTracks AutoPrep system by SRL, a clinical laboratory. The endpoints of this study were correlations between circulating tumor cells (CTC) count and therapeutic outcomes.

resultsAmong 39 patients with gastric cancer, 5 patients met the criterion. The incidence of this subtype was 12.8%. CTC counts ranged from 235 to 6440 cells/7.5 mL of peripheral blood (median of 1724). These values were much higher than common gastric cancers (2 cells). In chemo-sensitive cases, CTC counts decreased within 14 d (median) from 275, 235 and 1724 to 2, 7 and 66, respectively. On the other hand, CTC counts increased after treatment failure or insensitive case from 2, 7 and 6440 to 787, 513 and 7885, respectively. The correlation between CTC count and survival time showed a trend, but did not reach significance (Y = 234.6 - 0.03X, P = 0.085).

conclusionHigh CTC count is a biological hallmark of this subtype, and can be used as a direct and definitive indicator of therapeutic outcome.

Indexed as

Neoplastic Cells, CirculatingAdenocarcinomaAdultAgedAntineoplastic AgentsBone NeoplasmsCarcinoma, Signet Ring CellCell CountFemaleHumansMaleMiddle AgedPrognosisStomach NeoplasmsYoung AdultAntineoplastic AgentsBone metastasisCirculating tumor cellGastric cancerPredictive biomarkerPrognostic biomarker

Identifiers

PMID27468200
PMCPMC4948276
OpenAlexW2482367165

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.