Evidence map›Paper›PMID 27468184›Full record

ReviewWorld journal of gastroenterology2016

Exploring the role of molecular biomarkers as a potential weapon against gastric cancer: A review of the literature.

Marwa Matboli, Sarah El-Nakeep, Nourhan Hossam, Alaa Habieb, Ahmed E M Azazy, Ali E Ebrahim, Ziad Nagy, Omar Abdel-Rahman

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in World journal of gastroenterology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Circ_0004592: An auxiliary diagnostic biomarker for gastric cancer.World journal of gastrointestinal oncology · 2024
    Article
  3. Article
  4. Review
  5. GASTRIC CANCER WITH POSITIVE EXPRESSION OF ESTROGEN RECEPTOR ALPHA: A CASE SERIES FROM A SINGLE WESTERN CENTER.Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery · 2022
    Article
  6. Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Marwa MatboliMarwa Matboli, Nourhan Hossam, Alaa Habieb, Oncology Diagnostic Unit, Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Ain Shams University, Cairo 113331, Egypt.
Sarah El-NakeepMarwa Matboli, Nourhan Hossam, Alaa Habieb, Oncology Diagnostic Unit, Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Ain Shams University, Cairo 113331, Egypt.
Nourhan HossamMarwa Matboli, Nourhan Hossam, Alaa Habieb, Oncology Diagnostic Unit, Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Ain Shams University, Cairo 113331, Egypt.
Alaa HabiebMarwa Matboli, Nourhan Hossam, Alaa Habieb, Oncology Diagnostic Unit, Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Ain Shams University, Cairo 113331, Egypt.
Ahmed E M AzazyMarwa Matboli, Nourhan Hossam, Alaa Habieb, Oncology Diagnostic Unit, Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Ain Shams University, Cairo 113331, Egypt.
Ali E EbrahimMarwa Matboli, Nourhan Hossam, Alaa Habieb, Oncology Diagnostic Unit, Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Ain Shams University, Cairo 113331, Egypt.
Ziad NagyMarwa Matboli, Nourhan Hossam, Alaa Habieb, Oncology Diagnostic Unit, Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Ain Shams University, Cairo 113331, Egypt.
Omar Abdel-RahmanMarwa Matboli, Nourhan Hossam, Alaa Habieb, Oncology Diagnostic Unit, Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Ain Shams University, Cairo 113331, Egypt.
Creative Research Enterprises (United States) · USAin Shams University · EGArmed Forces College of Medicine · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gastric cancer (GC) is a global health problem and a major cause of cancer-related death with high recurrence rates ranging from 25% to 40% for GC patients staging II-IV. Unfortunately, while the majority of GC patients usually present with advanced tumor stage; there is still limited evidence-based therapeutic options. Current approach to GC management consists mainly of; endoscopy followed by, gastrectomy and chemotherapy or chemo-radiotherapy. Recent studies in GC have confirmed that it is a heterogeneous disease. Many molecular characterization studies have been performed in GC. Recent discoveries of the molecular pathways underlying the disease have opened the door to more personalized treatment and better predictable outcome. The identification of molecular markers is a useful tool for clinical managementin GC patients, assisting in diagnosis, evaluation of response to treatment and development of novel therapeutic modalities. While chemotherapeutic agents have certain physiological effects on the tumor cells, the prediction of the response is different from one type of tumor to the other. The specificity of molecular biomarkers is a principal feature driving their application in anticancer therapies. Here we are trying to focus on the role of molecular pathways of GC and well-established molecular markers that can guide the therapeutic management.

Indexed as

AdenocarcinomaAntineoplastic AgentsBiomarkers, TumorHumansMolecular Targeted TherapyPrognosisStomach NeoplasmsAntineoplastic AgentsBiomarkers, TumorBioinformaticsBiomarkersGastric cancerMolecular therapyTargeted therapy

Identifiers

PMID27468184
PMCPMC4948264
OpenAlexW2506343733

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.