ArticleCellulose (London, England)2016
Impacts of chemical modification on the toxicity of diverse nanocellulose materials to developing zebrafish.
Article in Cellulose (London, England), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 105 citations in OpenAlex.
- Cellulose-Based Hydrogels for Chronic Wound Healing: Bridging Biomaterial Design and Clinical Unmet Needs.Gels (Basel, Switzerland) · 2026Review
- Designing for Degradation: Transient Devices Enabled by (Nano)Cellulose.Advanced materials (Deerfield Beach, Fla.) · 2025Review
- Life-Cycle Risk Assessment of Second-Generation Cellulose Nanomaterials.Nanomaterials (Basel, Switzerland) · 2025Article
- Biobased Nanomaterials─The Role of Interfacial Interactions for Advanced Materials.Chemical reviews · 2023Review
- Review on Hybrid Reinforced Polymer Matrix Composites with Nanocellulose, Nanomaterials, and Other Fibers.Polymers · 2023Review
- Review of Functional Aspects of Nanocellulose-Based Pickering Emulsifier for Non-Toxic Application and Its Colloid Stabilization Mechanism.Molecules (Basel, Switzerland) · 2022Review
- Toxicological Assessment of Cellulose Nanomaterials: Oral Exposure.Nanomaterials (Basel, Switzerland) · 2022Review
- Fluorescently Labeled Cellulose Nanofibers for Environmental Health and Safety Studies.Nanomaterials (Basel, Switzerland) · 2021Article
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- Biorefinery Approach for Aerogels.Polymers · 2020Review
- In Vitro Evaluation of Lignin-Containing Nanocellulose.Materials (Basel, Switzerland) · 2020Article
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- Nanocellulose-Based Inks for 3D Bioprinting: Key Aspects in Research Development and Challenging Perspectives in Applications-A Mini Review.Bioengineering (Basel, Switzerland) · 2020Review
- Evaluation of Ecotoxicology Assessment Methods of Nanomaterials and Their Effects.Nanomaterials (Basel, Switzerland) · 2020Review
- TEMPO-Nanocellulose/CaMaterials (Basel, Switzerland) · 2020Article
- Inhibition of oil digestion in Pickering emulsions stabilized by oxidized cellulose nanofibrils for low-calorie food design.RSC advances · 2019Article
- Reactive oxygen species generation is likely a driver of copper based nanomaterial toxicity.Environmental science. Nano · 2018Article
- Potential Applications of Nanocellulose-Containing Materials in the Biomedical Field.Materials (Basel, Switzerland) · 2017Review
- Multimodality labeling strategies for the investigation of nanocrystalline cellulose biodistribution in a mouse model of breast cancer.Nuclear medicine and biologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Cellulose is an abundant and renewable resource currently being investigated for utility in nanomaterial form for various promising applications ranging from medical and pharmaceutical uses to mechanical reinforcement and biofuels. The utility of nanocellulose and wide implementation ensures increasing exposure to humans and the environment as nanocellulose-based technologies advance. Here, we investigate how differences in aspect ratio and changes to surface chemistry, as well as synthesis methods, influence the biocompatibility of nanocellulose materials using the embryonic zebrafish. Investigations into the toxicity of neutral, cationic and anionic surface functionalities revealed that surface chemistry had a minimal influence on the overall toxicity of nanocellulose materials. Higher aspect ratio cellulose nanofibers produced by mechanical homogenization were, in some cases, more toxic than other cellulose-based nanofibers or nanocrystals produced by chemical synthesis methods. Using fluorescently labeled nanocellulose we were able to show that nanocellulose uptake did occur in embryonic zebrafish during development. We conclude that the benign nature of nanocellulose materials makes them an ideal platform to systematically investigate the inherent surface features driving nanomaterial toxicity in order to create safer design principles for engineered nanoparticles.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.