Evidence map›Paper›PMID 27468173›Full record

ArticleClinical cardiology2016

Prognostic Role of Right Ventricular Function in Patients With Heart Failure Undergoing Cardiac Resynchronization Therapy.

Antonio Rapacciuolo, Stefano Maffè, Pietro Palmisano, Anna Ferraro, Antonella Cecchetto, Antonio D'Onofrio, Francesco Solimene, Paola Musatti, Paola Paffoni, Francesca Esposito and 5 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical cardiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. The saga of dyssynchrony imaging: Are we getting to the point.Frontiers in cardiovascular medicine · 2023
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Antonio RapacciuoloDepartment of Advanced Biomedical Sciences, Federico II University, Naples, Italy.
Stefano MaffèDivision of Cardiology, SS Trinità Hospital, Borgomanero, Italy.
Pietro PalmisanoCardiology Unit, Card. G. Panico Hospital, Tricase, Italy.
Anna FerraroDivision of Cardiology, Rivoli Hospital, Rivoli, Italy.
Antonella CecchettoDepartment of Cardiac, Thoracic and Vascular Sciences, University of Padua, Padua, Italy.
Antonio D'OnofrioDepartment of Cardiology, Monaldi Hospital, AORN Ospedali dei Colli, Naples, Italy.
Francesco SolimeneCasa di Cura Montevergine, Electrophysiology Department, Mercogliano, Italy.
Paola MusattiFondazione Poliambulanza, Cardiology Department, Brescia, Italy.
Paola PaffoniDivision of Cardiology, SS Trinità Hospital, Borgomanero, Italy.
Francesca EspositoDepartment of Advanced Biomedical Sciences, Federico II University, Naples, Italy.
Umberto ParraviciniDivision of Cardiology, SS Trinità Hospital, Borgomanero, Italy.
Alessia AgrestaDepartment of Advanced Biomedical Sciences, Federico II University, Naples, Italy.
Giovanni Luca BottoHospital Sant'Anna, Electrophysiology and Cardiac Stimulation Department San Fermo della Battaglia, Italy.
Maurizio MalacridaCardiac Rhythm Management, Boston Scientific Italia, Milan, Italy.
Giuseppe StabileClinica Mediterranea, Laboratory of Electrophysiology, Naples, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBecause 20% to 40% of patients undergoing cardiac resynchronization therapy (CRT) do not respond to it, identification of potential factors predicting response is a relevant research topic. HYPOTHESIS: There is a possible association between right ventricular function and response to CRT.

methodsWe analyzed 227 patients from the Cardiac Resynchronization Therapy Modular Registry (CRT-MORE) who received CRT according to current guidelines from March to December 2013. Response to therapy was defined as a decrease of ≥15% in left ventricular end-systolic volume (LVESV) at 6 months.

resultsThe tricuspid annular plane systolic excursion (TAPSE) value that best predicted improvement in LVESV (sensitivity 68%, specificity 54%) was 17 mm. Stratifying patients according to TAPSE, LVESV decreased ≥15% in 78% of patients with TAPSE >17 mm (vs 59% in patients with TAPSE ≤17 mm; P = 0.006). At multivariate analysis, TAPSE >17 mm was independently associated with LVESV improvement (odds ratio: 1.97, 95% confidence interval: 1.03-3.80, P < 0.05), together with ischemic etiology (odds ratio: 0.39, 95% confidence interval: 0.20-0.75, P < 0.01). These results were confirmed for New York Heart Association class III to IV patients (79% echocardiographic response rate in patients with TAPSE >17 mm vs 55% in patients with TAPSE <17 mm; P = 0.012).

conclusionsBaseline signs of right ventricular dysfunction suggest possible remodeling after CRT. A TAPSE value of 17 mm was identified as a good cutoff for predicting a better response to CRT in patients with both mildly symptomatic and severe heart failure.

Indexed as

Cardiac Resynchronization TherapyVentricular Function, RightAgedAged, 80 and overChi-Square DistributionEchocardiographyFemaleHeart FailureHumansItalyLogistic ModelsMaleMiddle AgedMultivariate AnalysisOdds RatioRegistriescardiac resynchronization therapyheart failureremodeling heart failureright ventricular function

Identifiers

PMID27468173
PMCPMC6490758

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.