SynthesisPLoS neglected tropical diseases2016
Fulminant Amebic Colitis after Corticosteroid Therapy: A Systematic Review.
Synthesis in PLoS neglected tropical diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
59 citing papers in PubMed, 2 syntheses or guidelines pooled it, 110 citations in OpenAlex.
- Parasitic colitis misdiagnosis as inflammatory bowel disease in high-income settings and association with poor clinical outcomes when exposed to corticosteroids: a systematic review of case reports.BMJ open gastroenterology · 2025Pooled it
- Antiamoebic drugs for treating amoebic colitis.The Cochrane database of systematic reviews · 2019Pooled it
- Amebiasis as a neglected tropical disease: Current knowledge gaps and future directions.PLoS neglected tropical diseases · 2026Review
- Cross-kingdom microbial interactions in the gut during inflammatory bowel disease.Journal of translational medicine · 2026Review
- Article
- Prevalence of Intestinal Amebiasis Among Saudi Residents Living in the Al-Baha Region, Saudi Arabia.Cureus · 2025Article
- Aspects of Genetic Diversity, Host Specificity and Public Health Significance of Single-Celled Intestinal Parasites Commonly Observed in Humans and Mostly Referred to as 'Non-Pathogenic'.APMIS : acta pathologica, microbiologica, et immunologica Scandinavica · 2025Review
- Article
- Decision tree-based learning and laboratory data mining: an efficient approach to amebiasis testing.Parasites & vectors · 2025Article
- Fulminant Amoebic Colitis.The American journal of tropical medicine and hygiene · 2025Article
- A new autochthonous case of amebiasis in Italy in a patient without risk factors: an alert for clinicians and laboratorians.Le infezioni in medicina · 2025Article
- A Case of Fulminant Amebiasis in a Female Commercial Sex Worker in Japan Requiring Subtotal Colectomy: A Literature Review and Case Report.Surgical case reports · 2025Article
- Recent advances in the diagnosis and management of amoebiasis.Frontline gastroenterology · 2025Review
- Article
- Fulminant amoebic colitis: a challenging diagnosis for the surgeon.Journal of surgical case reports · 2024Article
- Amoebic colitis in a 39-year-old man with HIV.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2024Article
- Effects of Serum Antibody Test Reagent Discontinuation on Diagnosis of Amebiasis in Japan: Interrupted Time-Series Analysis.The American journal of tropical medicine and hygiene · 2024Article
- Amoebic colitis-A diagnostic challenge on endoscopy: Case report.SAGE open medical case reports · 2024Article
- Amebiasis as a sexually transmitted infection: A re-emerging health problem in developed countries.Global health & medicine · 2023Review
- A case of fulminant amoebic colitis during systemic chemotherapy for gastric cancer.Clinical journal of gastroenterology · 2023Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
backgroundAmebic colitis, caused by intestinal infection with the parasite, Entamoeba histolytica, is a common cause of diarrhea worldwide. Fulminant amebic colitis is the most devastating complication of this infection, associated with both high mortality and morbidity. We conducted a review of the English literature to describe cases of fulminant amebic colitis associated with exposure to corticosteroid medications in order to identify the risk factors for poor outcome and determine difficulties in diagnosis and treatment. METHODOLOGY AND PRINCIPAL
findingsArticles reporting severe and fulminant forms of amebic colitis between 1991 and 2016 were collected. 525 records were screened to identify 24 cases for qualitative analysis associated with corticosteroid use. Cases arose from areas of high endemicity or travel to such areas. Most cases (14 of 24, 58%) were given corticosteroids for initially misdiagnosed colitis, mainly inflammatory bowel, resulting in rapid progression of disease. Nearly half of all cases underwent surgical intervention, and 25% of cases died, despite all patients eventually receiving treatment with metronidazole. The odds of death did not differ significantly by prior misdiagnosis, co-morbidities, bowel perforation or need for surgery. CONCLUSIONS AND SIGNIFICANCE: Infection with E. histolytica should be considered prior to the administration of corticosteroids, in particular for patients residing in endemic areas or those with appropriate travel history, especially prior to the diagnosis of inflammatory bowel disease. The development of preventative and treatment interventions are needed to improve outcomes of fulminant disease.
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