ArticleJournal of perinatology : official journal of the California Perinatal Association2016
Vitamin D and bronchopulmonary dysplasia in preterm infants.
Article in Journal of perinatology : official journal of the California Perinatal Association, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Association between vitamin D level and bronchopulmonary dysplasia: A systematic review and meta-analysis.PloS one · 2020Pooled it
- Early Vitamin D Supplementation in Infants Born Extremely Preterm and Fed Human Milk: A Randomized Controlled Trial.The Journal of pediatrics · 2025Trial
- Article
- Nonlinear relationship between vitamin D status on admission and bronchopulmonary dysplasia in preterm infants.Pediatric research · 2025Article
- Prenatal vitamin D supplementation mitigates inflammation-related alveolar remodeling in neonatal mice.American journal of physiology. Lung cellular and molecular physiology · 2023Article
- The association of serum vitamin D level and neonatal respiratory distress syndrome.Italian journal of pediatrics · 2023Article
- Vitamin d deficiency with high parathyroid hormone levels is related to late onset SEPSIS among preterm infants.BMC pregnancy and childbirth · 2023Article
- [Expert consensus on the follow-up management of bronchopulmonary dysplasia in preterm infants after discharge].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2022Article
- Vitamin D status in very low birth weight infants and response to vitamin D intake during their NICU stays: a prospective cohort study.Journal of perinatology : official journal of the California Perinatal Association · 2022Article
- Association between vitamin D deficiency at one month of age and bronchopulmonary dysplasia.Medicine · 2021Observational
- Nutrients and Microbiota in Lung Diseases of Prematurity: The Placenta-Gut-Lung Triangle.Nutrients · 2020Review
- [Protective effect of vitamin D against hyperoxia-induced bronchopulmonary dysplasia in newborn mice].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2019Article
- Association of vitamin D status at birth and respiratory outcomes in preterm infants.Korean journal of pediatrics · 2019Article
- Association between vitamin D level at birth and respiratory morbidities in very-low-birth-weight infants.Korean journal of pediatrics · 2019Article
- The Utility of Comprehensive Metabolic Panel Tests for the Prediction of Bronchopulmonary Dysplasia in Extremely Premature Infants.Disease markers · 2019Article
- Vitamin D and associated perinatal-neonatal outcomes among extremely low-birth-weight infants.Journal of perinatology : official journal of the California Perinatal Association · 2018Observational
- Vitamin D in pediatric age: consensus of the Italian Pediatric Society and the Italian Society of Preventive and Social Pediatrics, jointly with the Italian Federation of Pediatricians.Italian journal of pediatrics · 2018Review
- Vitamin D and IL-10 Deficiency in Preterm Neonates With Bronchopulmonary Dysplasia.Frontiers in pediatrics · 2018Article
- [Association between serum 25(OH)D levels at birth and bronchopulmonary dysplasia in preterm infants].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2017Article
- Vitamin D Enhances Alveolar Development in Antenatal Lipopolysaccharide-Treated Rats through the Suppression of Interferon-γ Production.Frontiers in immunology · 2017Article
Corrections and comments
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Authors and funding
9 authors at 6 institutions in 2 countries.
Funding
Abstract
objectiveVitamin D deficiency is associated with asthma and reactive airway disease in childhood but its potential contribution to bronchopulmonary dysplasia (BPD) in preterm infants is unknown. Preterm infants have lower levels of 25-hydroxyvitamin D (25(OH)D) at birth and are at risk for nutritional deficiencies after birth. The objective of the study was to evaluate the association of 25(OH)D concentrations at birth and at 36 weeks' corrected gestational age with BPD in preterm infants born before 29 completed weeks of gestation. STUDY
designWe collected umbilical cord blood samples from 44 preterm infants (gestational age <29 weeks) delivered at Brigham and Women's Hospital in Boston. In addition, with parental consent we collected venous samples at 36 weeks' corrected age from 20 preterm infants born before 29 weeks' gestation (including 6 infants with previously collected cord blood). Samples were frozen at -80 °C until subsequent measurement of 25(OH)D levels by chemiluminescence. We used multivariable logistic models to adjust for gestational age and considered other confounding variables, including maternal race, age, mode of delivery and infant sex.
resultsAmong 44 infants, 41 (93.2%) survived and 3 (6.8%) died before 36 weeks' corrected age. Median 25(OH)D levels at birth were 30.4 ng ml(-1) in preterm infants who subsequently died or developed BPD and 33.8 ng ml(-1) in infants who survived without BPD (P=0.6). Median 25(OH)D levels at corrected age of 36 weeks were 59.0 ng ml(-1) among survivors without BPD and 64.2 ng ml(-1) among survivors with BPD (P=0.9). Neither cord blood nor 36 weeks' corrected 25(OH)D levels were associated with odds of death or BPD (adjusted odds ratio (OR) 1.00, 95% confidence interval (CI): 0.73 to 1.37; and OR 0.93, 95% CI: 0.61 to 1.43, respectively).
conclusionsAmong this population of extremely preterm infants neither cord blood nor the 36 weeks' corrected age 25(OH)D levels were associated with development of BPD. Notably, at the current level of supplementation, all extremely preterm infants in our cohort had achieved 25(OH)D levels >30 ng ml(-1) by 36 weeks' corrected age, which is thought to represent sufficiency in adult and pediatric populations.
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