ArticlePloS one2016
Detection of Successful and Unsuccessful Pregnancies in Mice within Hours of Pairing through Frequency Analysis of High Temporal Resolution Core Body Temperature Data.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 54 citations in OpenAlex.
- Pregnancy damps thermoregulatory rhythms across timescales through neural estrogen signaling in mice.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Monitoring reproduction in cryptic small mammals; using body temperature to identify parturition in an endangered rodent.Biology open · 2026Article
- Non-invasive ovulation tracking enables genetic engineering in wild rodents.Cell reports methods · 2026Article
- Augmenting Circadian Biology Research With Data Science.Journal of biological rhythms · 2025Review
- A physiological and histological atlas of reproduction in the North American deer mouse (Peromyscus maniculatus).PloS one · 2025Article
- Determination of vaginal cytology and MMP-9 expression during early pregnancy in mice.Veterinary and animal science · 2024Article
- Deep learning model using continuous skin temperature data predicts labor onset.BMC pregnancy and childbirth · 2024Article
- Lung microvascular occlusion by platelet-rich neutrophil-platelet aggregates promotes cigarette smoke-induced severe flu.JCI insight · 2024Article
- Variability of temperature measurements recorded by a wearable device by biological sex.Biology of sex differences · 2023Article
- Predicting labor onset relative to the estimated date of delivery using smart ring physiological data.NPJ digital medicine · 2023Article
- Neural substrates underlying rhythmic coupling of female reproductive and thermoregulatory circuits.Frontiers in physiology · 2023Review
- Modified Wavelet Analyses Permit Quantification of Dynamic Interactions Between Ultradian and Circadian Rhythms.Journal of biological rhythms · 2022Article
- The Post-Roe Political Landscape Demands a Morality of Caution for Women's Health.Journal of medical Internet research · 2022Article
- Birth, love, and fear: Physiological networks from pregnancy to parenthood.Comprehensive psychoneuroendocrinology · 2022Review
- Sex Differences in Pubertal Circadian and Ultradian Rhythmic Development Under Semi-naturalistic Conditions.Journal of biological rhythms · 2022Article
- Female mice exhibit less overall variance, with a higher proportion of structured variance, than males at multiple timescales of continuous body temperature and locomotive activity records.Biology of sex differences · 2022Article
- Feasibility of continuous distal body temperature for passive, early pregnancy detection.PLOS digital health · 2022Article
- Article
- Maternal stress during pregnancy alters fetal cortico-cerebellar connectivity in utero and increases child sleep problems after birth.Scientific reports · 2021Article
- Adolescent Development of Biological Rhythms in Female Rats: Estradiol Dependence and Effects of Combined Contraceptives.Frontiers in physiology · 2021Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Many controllable factors negatively impact fetal development, underscoring the importance of early pregnancy detection and identification of events that reliably predict potential complications. Clinically, core body temperature (CBT) is used to aid family planning and pregnancy detection. However, such temperature data typically are gathered in single, daily measurements. In animal studies, interventions or cell/tissue harvesting at defined stages of fetal development are arduous, requiring timed mating by trained observers. The value of continuous temperature measurements remains largely unexplored, but the advent of small, inexpensive, and increasingly ubiquitous, accurate sensor devices makes continuous measures feasible. Here, using a mouse model, we show that continuous, 1-min resolution CBT measurements reliably allow for the earliest and most accurate detection of pregnancy (100%, within 14 h of initial pairing), without requiring interaction with the animal for data collection. This method also reveals a subset of females that exhibit a pregnancy-like response following pairing that persists for a variable number of days. Application of wavelet analysis that permits frequency analysis while preserving temporal resolution, uncovers significant differences in ultradian frequencies of CBT; these rhythms are significantly increased in the 12 h after the day of pairing for pregnancies carried to term compared to apparent pregnancies that failed. High temporal resolution CBT and wavelet analysis permit strikingly early detection and separation of successful pregnancies and pregnancy-like events.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.