Evidence map›Paper›PMID 27467284›Full record

ArticleGenes and immunity2016

Specific HLA genotypes confer susceptibility to acute necrotizing encephalopathy.

A Hoshino, M Saitoh, T Miyagawa, M Kubota, J-I Takanashi, A Miyamoto, K Tokunaga, A Oka, M Mizuguchi

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In one paragraph

Article in Genes and immunity, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 28 citations in OpenAlex.

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  11. Association ofFrontiers in neuroscience · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

A HoshinoDepartment of Developmental Medical Sciences, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
M SaitohDepartment of Developmental Medical Sciences, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
T MiyagawaDepartment of Human Genetics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
M KubotaDivision of Neurology, National Center for Child Health and Development, Tokyo, Japan.
J-I TakanashiDepartment of Pediatrics, Tokyo Women's Medical University Yachiyo Medical Center, Yachiyo, Japan.
A MiyamotoDepartment of Pediatrics, Asahikawa Habilitation Center for Disabled Children, Asahikawa, Japan.
K TokunagaDepartment of Human Genetics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
A OkaDepartment of Pediatrics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
M MizuguchiDepartment of Developmental Medical Sciences, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
The University of Tokyo · JPAsahikawa University · JPNational Center For Child Health and Development · JPTokyo Women's Medical University Yachiyo Medical Center

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute necrotizing encephalopathy (ANE) is a rare and severe syndrome of acute encephalopathy triggered by viral infections. Cytokine storm is considered as the main pathogenetic mechanism of ANE. ANE is prevalent in East Asia, suggesting the association of host genetic factors. To elucidate the genetic background of Japanese ANE, we examined genotypes of human leukocyte antigen (HLA)-A, C, B, DRB1, DQB1 and DPB1 in 31 patients. Significant positive association was observed in both the allele frequency and positivity of DRB1*09:01 (P=0.043 and 0.025, respectively), as well as those of DQB1*03:03 (P=0.034 and 0.026, respectively). The carrier frequency of DRB1*09:01 and DQB1*03:03 alleles was higher in the patients (45.16%) than in controls (28.57%). These alleles are more common in East Asian than in European populations, and are reportedly associated with various autoimmune diseases in Japanese patients. Our data provide further evidence that altered immune response based on individual HLA genotypes may contribute to ANE pathogenesis.

Indexed as

AllelesDisease SusceptibilityEncephalitis, ViralGenetic Predisposition to DiseaseGenotypeHLA AntigensHumansLeukoencephalitis, Acute HemorrhagicHLA Antigens

Identifiers

PMID27467284
OpenAlexW2493885580

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.