Evidence map›Paper›PMID 27467133›Full record

ArticleMolecular nutrition & food research2016

Polymorphisms in stearoyl coa desaturase and sterol regulatory element binding protein interact with N-3 polyunsaturated fatty acid intake to modify associations with anthropometric variables and metabolic phenotypes in Yup'ik people.

Dominick J Lemas, Yann C Klimentidis, Stella Aslibekyan, Howard W Wiener, Diane M O'Brien, Scarlett E Hopkins, Kimber L Stanhope, Peter J Havel, David B Allison, Jose R Fernandez and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular nutrition & food research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.1field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 1 country.

Dominick J LemasCenter for Alaska Native Health Research, Institute of Arctic Biology, University of Alaska Fairbanks, Fairbanks, AK, USA.
Yann C KlimentidisDepartment of Epidemiology and Biostatistics, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ, USA.
Stella AslibekyanDepartment of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA.
Howard W WienerDepartment of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA.
Diane M O'BrienCenter for Alaska Native Health Research, Institute of Arctic Biology, University of Alaska Fairbanks, Fairbanks, AK, USA.
Scarlett E HopkinsCenter for Alaska Native Health Research, Institute of Arctic Biology, University of Alaska Fairbanks, Fairbanks, AK, USA.
Kimber L StanhopeDepartment of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, Davis, CA, USA.
Peter J HavelDepartment of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, Davis, CA, USA.
David B AllisonDepartment of Biostatistics, Section on Statistical Genetics, University of Alabama at Birmingham, Birmingham, AL, USA.
Jose R FernandezNutrition Obesity Research Center, University of Alabama at Birmingham, Birmingham, AL, USA.
Hemant K TiwariDepartment of Biostatistics, Section on Statistical Genetics, University of Alabama at Birmingham, Birmingham, AL, USA.
Bert B BoyerCenter for Alaska Native Health Research, Institute of Arctic Biology, University of Alaska Fairbanks, Fairbanks, AK, USA.
University of Alabama at Birmingham · USNative Health · USUniversity of California, Davis · USArizona Science Center · USEnergetics (United States) · USUniversity of Alaska Fairbanks · US

Funding

Why is the prevalence of obesity so high in U.S. Southern States? Regional predictors of BMI and obesity treatment response.P30DK056336 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BARBARA A GOWER · 2000 to 2026
$31.9M
YUP'IK PERCEPTIONS OF BODY WEIGHT AND DIABETESP20RR016430 · NCRR · UNIVERSITY OF ALASKA FAIRBANKS · PI O'BRIEN, DIANE H. · 2001 to 2011
$23.4M
X-LINKED EXTENSION OF THE REVISED HASEMAN-ELSTON ALGORITHM FOR LINKAGE ANALYSISP41RR003655 · NCRR · LOUISIANA STATE UNIV HSC NEW ORLEANS · PI ELSTON, ROBERT C. · 1987 to 2011
$11.5M
Pilot Project ProgramP30GM103325 · NIGMS · UNIVERSITY OF ALASKA FAIRBANKS · PI O'BRIEN, DIANE MARIE · 2012 to 2016
$5.3M
Genetics of Obesity in Yup'ik EskimosR01DK074842 · NIDDK · UNIVERSITY OF ALASKA FAIRBANKS · PI BOYER, BERT BRANDON · 2007 to 2011
$2.8M
Whole-Genome Prediction of Type-2 Diabetes Susceptibility in Various PopulationsK01DK095032 · NIDDK · UNIVERSITY OF ARIZONA · PI KLIMENTIDIS, YANN CHARLES · 2012 to 2014
$440k
NCRR NIH HHS P20 RR016430NCRR NIH HHS P41 RR003655NIDDK NIH HHS K01 DK095032NIDDK NIH HHS P30 DK056336NIDDK NIH HHS R01 DK074842NIGMS NIH HHS P30 GM103325
6 · The paper itself

Abstract

scopen-3 polyunsaturated fatty acid (n-3 PUFA) intake is associated with protection from obesity; however, the mechanisms of protection remain poorly characterized. The stearoyl CoA desaturase (SCD), insulin-sensitive glucose transporter (SLC2A4), and sterol regulatory element binding protein (SREBF1) genes are transcriptionally regulated by n-3 PUFA intake and harbor polymorphisms associated with obesity. The present study investigated how consumption of n-3 PUFA modifies associations between SCD, SLC2A4, and SREBF1 polymorphisms and anthropometric variables and metabolic phenotypes. MATERIALS AND

methodsAnthropometric variables and metabolic phenotypes were measured in a cross-sectional sample of Yup'ik individuals (n = 1135) and 33 polymorphisms were tested for main effects and interactions using linear models that account for familial correlations. n-3 PUFA intake was estimated using red blood cell nitrogen stable isotope ratios. SCD polymorphisms were associated with ApoA1 concentration and n-3 PUFA interactions with SCD polymorphisms were associated with reduced fasting cholesterol levels and waist-to-hip ratio. SLC2A4 polymorphisms were associated with hip circumference, high-density lipoprotein and ApoA1 concentrations. SREBF1 polymorphisms were associated with low-density lipoprotein and HOMA-IR and n-3 PUFA interactions were associated with reduced fasting insulin and HOMA-IR levels.

conclusionThe results suggest that an individual's genotype may interact with dietary n-3 PUFAs in ways that are associated with protection from obesity-related diseases in Yup'ik people.

Indexed as

Polymorphism, Single NucleotideAdultAlaskaAnthropometryApolipoprotein A-ICholesterolCross-Sectional StudiesDiabetes Mellitus, Type 2DietFatty Acids, Omega-3FemaleGlucose Transporter Type 4Glycated HemoglobinHumansMaleObesityAPOA1 protein, humanApolipoprotein A-ICholesterolFatty Acids, Omega-3Glucose Transporter Type 4Glycated HemoglobinSLC2A4 protein, humanSREBF1 protein, humanStearoyl-CoA DesaturaseSterol Regulatory Element Binding Protein 1Alaska NativeBMIGene-by-environment interactionsn-3 PUFA

Identifiers

PMID27467133
PMCPMC5148654
OpenAlexW2497024174

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.