ArticleJournal of magnetic resonance imaging : JMRI2017
Abnormal structural and functional hypothalamic connectivity in mild traumatic brain injury.
Article in Journal of magnetic resonance imaging : JMRI, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 3 of them syntheses that pooled it.
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Who cites it
14 citing papers in PubMed, 3 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Functional Connectivity Changes on Resting-State fMRI after Mild Traumatic Brain Injury: A Systematic Review.AJNR. American journal of neuroradiology · 2024Pooled it
- Diffusion-Weighted Imaging in Mild Traumatic Brain Injury: A Systematic Review of the Literature.Neuropsychology review · 2023Pooled it
- The second decade of DTI in TBI part 1: a systematic review of mild TBI.Frontiers in neurologyPooled it
- Connecting the Dots: The Role of Pediatric Concussion on Pubertal Hormones and Psychological Health.The Journal of adolescent health : official publication of the Society for Adolescent Medicine · 2026Article
- Establishing the link between post-concussive symptoms and brain network dysfunction: A systematic scoping review of neuroimaging evidence.NeuroImage. Clinical · 2026Article
- Role of the central nervous system in cell non-autonomous signaling mechanisms of aging and longevity in mammals.The journal of physiological sciences : JPS · 2024Review
- Nuclei-specific hypothalamus networks predict a dimensional marker of stress in humans.Nature communications · 2024Article
- Disrupted hypothalamic functional connectivity related to cognitive impairment after diffuse axonal injury.Medicine · 2021Observational
- Acute Diffusion Tensor and Kurtosis Imaging and Outcome following Mild Traumatic Brain Injury.Journal of neurotrauma · 2021Article
- The Prevalence and Stability of Sleep-Wake Disturbance and Fatigue throughout the First Year after Mild Traumatic Brain Injury.Journal of neurotrauma · 2020Article
- Altered hypothalamic functional connectivity in post-traumatic headache after mild traumatic brain injury.The journal of headache and pain · 2020Article
- Evaluating spatiotemporal microstructural alterations following diffuse traumatic brain injury.NeuroImage. Clinical · 2020Article
- The frequency and the diagnosis of pituitary dysfunction after traumatic brain injury.Pituitary · 2019Review
- Small world properties changes in mild traumatic brain injury.Journal of magnetic resonance imaging : JMRI · 2017Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
purposeTo investigate whether there is imaging evidence of hypothalamic injury in patients with mild traumatic brain injury (MTBI), which is a major public health problem due to the high prevalence and difficulty in diagnosis and treatment. MATERIALS AND
methodsTwenty-four patients (mean age 34.2, range, 18-56 years) with symptomatic MTBI and 22 age-matched healthy controls (mean age 37.0, range 20-61 years) participated in the study. Diffusion kurtosis imaging was performed with diffusion-weighted images acquired along 30 gradient directions and three b-values (b = 0, 1000, 2000 s/mm
resultsThere were significantly reduced mean kurtosis (P = 0.0092) and radial kurtosis (P = 0.0078) in patients as compared to controls in the hypothalamus. Furthermore, there was a significant negative correlation (r = -0.675, P = 0.0007) between radial kurtosis in the hypothalamus and fatigue severity scale in patients. The MTBI group also showed disrupted hypothalamic RSNs, with significantly decreased positive connectivity in medial prefrontal cortex, inferior posterior parietal, and cingulate regions but increased connectivity in the peri-hypothalamic regions and cerebellum, together with significantly decreased negative RSNs in visual and bilateral premotor areas (cluster corrected P < 0.05).
conclusionOur results show disruption of functional and structural hypothalamic connectivity in patients with MTBI, and might further the understanding of an array of clinical symptoms in MTBI such as sleep disturbance and fatigue. LEVEL OF EVIDENCE: 2 J. Magn. Reson. Imaging 2017;45:1105-1112.
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