ArticleACS applied materials & interfaces2016
Polymer Encapsulation of an Amorphous Pharmaceutical by initiated Chemical Vapor Deposition for Enhanced Stability.
Article in ACS applied materials & interfaces, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 44 citations in OpenAlex.
- Tuning the Porosity of Piezoelectric Zinc Oxide Thin Films Obtained from Molecular Layer-Deposited "Zincones".Materials (Basel, Switzerland) · 2022Article
- Initiated Chemical Vapor Deposition Kinetics of Poly(4-aminostyrene).Frontiers in bioengineering and biotechnology · 2021Article
- Controlled Release Utilizing Initiated Chemical Vapor Deposited (iCVD) of Polymeric Nanolayers.Frontiers in bioengineering and biotechnology · 2021Review
- Conformal Coating of Powder by Initiated Chemical Vapor Deposition on Vibrating Substrate.Pharmaceutics · 2020Article
- Vapor-deposited functional polymer thin films in biological applications.Journal of materials chemistry. B · 2020Review
- Initiated Chemical Vapor Deposition of Crosslinked Organic Coatings for Controlling Gentamicin Delivery.Pharmaceutics · 2020Article
- Wrinkling of an Enteric Coating Induced by Vapor-Deposited Stimuli-Responsive Hydrogel Thin Films.The journal of physical chemistry. C, Nanomaterials and interfaces · 2019Article
- An Update of Moisture Barrier Coating for Drug Delivery.Pharmaceutics · 2019Review
- Article
- High-efficiency freezing-induced loading of inorganic nanoparticles and proteins into micron- and submicron-sized porous particles.Scientific reports · 2018Article
- Controlling Indomethacin Release through Vapor-Phase Deposited Hydrogel Films by Adjusting the Cross-linker Density.Scientific reports · 2018Article
- Solvent Vapor Annealing of Amorphous Carbamazepine Films for Fast Polymorph Screening and Dissolution Alteration.ACS omega · 2017Article
- Simple method for the quantitative analysis of thin copolymer films on substrates by infrared spectroscopy using direct calibration.Analytical methods : advancing methods and applications · 2017Article
- Vapor-phase-synthesized fluoroacrylate polymer thin films: thermal stability and structural properties.Beilstein journal of nanotechnology · 2017Article
- Wrinkle formation in a polymeric drug coating deposited via initiated chemical vapor deposition.Soft matter · 2016Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The usage of amorphous solids in practical applications, such as in medication, is commonly limited by the poor long-term stability of this state, because unwanted crystalline transitions occur. In this study, three different polymeric coatings are investigated for their ability to stabilize amorphous films of the model drug clotrimazole and to protect against thermally induced transitions. For this, drop cast films of clotrimazole are encapsulated by initiated chemical vapor deposition (iCVD), using perfluorodecyl acrylate (PFDA), hydroxyethyl methacrylate (HEMA), and methacrylic acid (MAA). The iCVD technique operates under solvent-free conditions at low temperatures, thus leaving the solid state of the encapsulated layer unaffected. Optical microscopy and X-ray diffraction data reveal that at ambient conditions of about 22 °C, any of these iCVD layers extends the lifetime of the amorphous state significantly. At higher temperatures (50 or 70 °C), the p-PFDA coating is unable to provide protection, while the p-HEMA and p-MAA strongly reduce the crystallization rate. Furthermore, p-HEMA and p-MAA selectively facilitate a preferential alignment of clotrimazole and, interestingly, even suppress crystallization upon a temporary, rapid temperature increase (3 °C/min, up to 150 °C). The results of this study demonstrate how a polymeric coating, synthesized directly on top of an amorphous phase, can act as a stabilizing agent against crystalline transitions, which makes this approach interesting for a variety of applications.
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