ArticlePediatric research2016
Maternal creatine supplementation during pregnancy prevents acute and long-term deficits in skeletal muscle after birth asphyxia: a study of structure and function of hind limb muscle in the spiny mouse.
Article in Pediatric research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- Creatine in Health and Disease.Nutrients · 2021Pooled it
- Risk of Adverse Outcomes in Females Taking Oral Creatine Monohydrate: A Systematic Review and Meta-Analysis.Nutrients · 2020Pooled it
- Metabolism and homeostasis of energy in trophoblast cells of the placenta: from development to disease†.Biology of reproduction · 2026Review
- Creatine in women's health: bridging the gap from menstruation through pregnancy to menopause.Journal of the International Society of Sports Nutrition · 2025Review
- Part II. Common questions and misconceptions about creatine supplementation: what does the scientific evidence really show?Journal of the International Society of Sports Nutrition · 2025Review
- A short review of the most common safety concerns regarding creatine ingestion.Frontiers in nutrition · 2025Review
- Creatine in the fetal brain: A regional investigation of acute global hypoxia and creatine supplementation in a translational fetal sheep model.Frontiers in cellular neuroscience · 2023Article
- Treatments and therapeutic protocols for the recovery of an asphyxiated new-born: A review of pre-clinical and clinical studies in human neonates and in different animal models.Veterinarni medicina · 2022Review
- Review
- Creatine and pregnancy outcomes, a prospective cohort study in low-risk pregnant women: study protocol.BMJ open · 2019Article
- Evaluation of 3K3A-Activated Protein C to Treat Neonatal Hypoxic Ischemic Brain Injury in the Spiny Mouse.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2019Article
- Antenatal prevention of cerebral palsy and childhood disability: is the impossible possible?The Journal of physiology · 2018Review
- Renal dysfunction in early adulthood following birth asphyxia in male spiny mice, and its amelioration by maternal creatine supplementation during pregnancy.Pediatric research · 2017Article
- International Society of Sports Nutrition position stand: safety and efficacy of creatine supplementation in exercise, sport, and medicine.Journal of the International Society of Sports Nutrition · 2017Review
- Understanding the Full Spectrum of Organ Injury Following Intrapartum Asphyxia.Frontiers in pediatrics · 2017Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMaternal antenatal creatine supplementation protects the brain, kidney, and diaphragm against the effects of birth asphyxia in the spiny mouse. In this study, we examined creatine's potential to prevent damage to axial skeletal muscles.
methodsPregnant spiny mice were fed a control or creatine-supplemented diet from mid-pregnancy, and 1 d before term (39 d), fetuses were delivered by c-section with or without 7.5 min of birth asphyxia. At 24 h or 33 ± 2 d after birth, gastrocnemius muscles were obtained for ex-vivo study of twitch-tension, muscle fatigue, and structural and histochemical analysis.
resultsBirth asphyxia significantly reduced cross-sectional area of all muscle fiber types (P < 0.05), and increased fatigue caused by repeated tetanic contractions at 24 h of age (P < 0.05). There were fewer (P < 0.05) Type I and IIa fibers and more (P < 0.05) Type IIb fibers in male gastrocnemius at 33 d of age. Muscle oxidative capacity was reduced (P < 0.05) in males at 24 h and 33 d and in females at 24 h only. Maternal creatine treatment prevented all asphyxia-induced changes in the gastrocnemius, improved motor performance.
conclusionThis study demonstrates that creatine loading before birth protects the muscle from asphyxia-induced damage at birth.
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