Trial reportThe Journal of clinical endocrinology and metabolism2016
Plasma Taurine, Diabetes Genetic Predisposition, and Changes of Insulin Sensitivity in Response to Weight-Loss Diets.
Open access · bronzeAbstract readRandomized Controlled Trial
In one paragraph
Trial report in The Journal of clinical endocrinology and metabolism, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
2.1field-weighted citation impact, top 15% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- Pooled it
- n-3 Fatty Acid Biomarkers and Incident Type 2 Diabetes: An Individual Participant-Level Pooling Project of 20 Prospective Cohort Studies.Diabetes care · 2021Pooled it
- Trial
- The relationship between plasma taurine levels in early pregnancy and later gestational diabetes mellitus risk in Chinese pregnant women.Scientific reports · 2021Trial
- Trial
- Taurine reduces intracellular glucose accumulation in fructose-treated Caenorhabditis elegans.Amino acids · 2026Article
- Flattening the biological age curve by improving metabolic health: to taurine or not to taurine, that' s the question.Journal of geriatric cardiology : JGC · 2023Article
- Metabolites, gene expression, and gut microbiota profiles suggest the putative mechanisms via which dietary creatine increases the serum taurine and g-ABA contents in Megalobrama amblycephala.Fish physiology and biochemistry · 2023Article
- The effects of taurine supplementation on diabetes mellitus in humans: A systematic review and meta-analysis.Food chemistry. Molecular sciences · 2022Article
- Beneficial Effects of Taurine on Metabolic Parameters in Animals and Humans.Journal of obesity & metabolic syndrome · 2022Review
- Taurine and Exercise: Synergistic Effects on Adipose Tissue Metabolism and Inflammatory Process in Obesity.Advances in experimental medicine and biology · 2022Article
- Symptom Science: Omics and Response to Non-Pharmacological Interventions.Biological research for nursing · 2021Article
- Article
- Lessons Learned from the POUNDS Lost Study: Genetic, Metabolic, and Behavioral Factors Affecting Changes in Body Weight, Body Composition, and Cardiometabolic Risk.Current obesity reports · 2019Review
- The Relationship between Plasma Taurine Levels and Diabetic Complications in Patients with Type 2 Diabetes Mellitus.Biomolecules · 2019Article
- Effects and Mechanisms of Taurine as a Therapeutic Agent.Biomolecules & therapeutics · 2018Review
- Plasma metabolites associated with type 2 diabetes in a Swedish population: a case-control study nested in a prospective cohort.Diabetologia · 2018Article
- [Doping with illegal and legal substances in old age].Zeitschrift fur Gerontologie und Geriatrie · 2018Review
- Gene-Diet Interaction and Precision Nutrition in Obesity.International journal of molecular sciences · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 5 institutions in 3 countries.
Yan ZhengDepartment of Nutrition (Y.Z., F.M.S., L.Q.), Harvard T.H. Chan School of Public Health, Boston, Massachusetts 02115; Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics (U.C., J. T.), University Hospital-Leipzig, 04103 Leipzig, Germany; Department of Epidemiology, School of Public Health and Tropical Medicine (T.H., T.W., Y.H., L.Q.), Tulane University, New Orleans, Louisiana 70118; Department of Epidemiology, Saw Swee Hock School of Public Health (T.H.), National University of Singapore, Singapore 119077; Department of Epidemiology (W.M.), Harvard T.H. Chan School of Public Health, Boston, Massachusetts 02115; Pennington Biomedical Research Center (G.A.B.), Louisiana State University, Baton Rouge, Louisiana 70808; and Channing Division of Network Medicine, Department of Medicine (L.Q.), Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115.
Uta CeglarekDepartment of Nutrition (Y.Z., F.M.S., L.Q.), Harvard T.H. Chan School of Public Health, Boston, Massachusetts 02115; Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics (U.C., J. T.), University Hospital-Leipzig, 04103 Leipzig, Germany; Department of Epidemiology, School of Public Health and Tropical Medicine (T.H., T.W., Y.H., L.Q.), Tulane University, New Orleans, Louisiana 70118; Department of Epidemiology, Saw Swee Hock School of Public Health (T.H.), National University of Singapore, Singapore 119077; Department of Epidemiology (W.M.), Harvard T.H. Chan School of Public Health, Boston, Massachusetts 02115; Pennington Biomedical Research Center (G.A.B.), Louisiana State University, Baton Rouge, Louisiana 70808; and Channing Division of Network Medicine, Department of Medicine (L.Q.), Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115.
Tao HuangDepartment of Nutrition (Y.Z., F.M.S., L.Q.), Harvard T.H. Chan School of Public Health, Boston, Massachusetts 02115; Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics (U.C., J. T.), University Hospital-Leipzig, 04103 Leipzig, Germany; Department of Epidemiology, School of Public Health and Tropical Medicine (T.H., T.W., Y.H., L.Q.), Tulane University, New Orleans, Louisiana 70118; Department of Epidemiology, Saw Swee Hock School of Public Health (T.H.), National University of Singapore, Singapore 119077; Department of Epidemiology (W.M.), Harvard T.H. Chan School of Public Health, Boston, Massachusetts 02115; Pennington Biomedical Research Center (G.A.B.), Louisiana State University, Baton Rouge, Louisiana 70808; and Channing Division of Network Medicine, Department of Medicine (L.Q.), Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115.
Tiange WangDepartment of Nutrition (Y.Z., F.M.S., L.Q.), Harvard T.H. Chan School of Public Health, Boston, Massachusetts 02115; Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics (U.C., J. T.), University Hospital-Leipzig, 04103 Leipzig, Germany; Department of Epidemiology, School of Public Health and Tropical Medicine (T.H., T.W., Y.H., L.Q.), Tulane University, New Orleans, Louisiana 70118; Department of Epidemiology, Saw Swee Hock School of Public Health (T.H.), National University of Singapore, Singapore 119077; Department of Epidemiology (W.M.), Harvard T.H. Chan School of Public Health, Boston, Massachusetts 02115; Pennington Biomedical Research Center (G.A.B.), Louisiana State University, Baton Rouge, Louisiana 70808; and Channing Division of Network Medicine, Department of Medicine (L.Q.), Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115.
Yoriko HeianzaDepartment of Nutrition (Y.Z., F.M.S., L.Q.), Harvard T.H. Chan School of Public Health, Boston, Massachusetts 02115; Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics (U.C., J. T.), University Hospital-Leipzig, 04103 Leipzig, Germany; Department of Epidemiology, School of Public Health and Tropical Medicine (T.H., T.W., Y.H., L.Q.), Tulane University, New Orleans, Louisiana 70118; Department of Epidemiology, Saw Swee Hock School of Public Health (T.H.), National University of Singapore, Singapore 119077; Department of Epidemiology (W.M.), Harvard T.H. Chan School of Public Health, Boston, Massachusetts 02115; Pennington Biomedical Research Center (G.A.B.), Louisiana State University, Baton Rouge, Louisiana 70808; and Channing Division of Network Medicine, Department of Medicine (L.Q.), Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115.
Wenjie MaDepartment of Nutrition (Y.Z., F.M.S., L.Q.), Harvard T.H. Chan School of Public Health, Boston, Massachusetts 02115; Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics (U.C., J. T.), University Hospital-Leipzig, 04103 Leipzig, Germany; Department of Epidemiology, School of Public Health and Tropical Medicine (T.H., T.W., Y.H., L.Q.), Tulane University, New Orleans, Louisiana 70118; Department of Epidemiology, Saw Swee Hock School of Public Health (T.H.), National University of Singapore, Singapore 119077; Department of Epidemiology (W.M.), Harvard T.H. Chan School of Public Health, Boston, Massachusetts 02115; Pennington Biomedical Research Center (G.A.B.), Louisiana State University, Baton Rouge, Louisiana 70808; and Channing Division of Network Medicine, Department of Medicine (L.Q.), Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115.
George A BrayDepartment of Nutrition (Y.Z., F.M.S., L.Q.), Harvard T.H. Chan School of Public Health, Boston, Massachusetts 02115; Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics (U.C., J. T.), University Hospital-Leipzig, 04103 Leipzig, Germany; Department of Epidemiology, School of Public Health and Tropical Medicine (T.H., T.W., Y.H., L.Q.), Tulane University, New Orleans, Louisiana 70118; Department of Epidemiology, Saw Swee Hock School of Public Health (T.H.), National University of Singapore, Singapore 119077; Department of Epidemiology (W.M.), Harvard T.H. Chan School of Public Health, Boston, Massachusetts 02115; Pennington Biomedical Research Center (G.A.B.), Louisiana State University, Baton Rouge, Louisiana 70808; and Channing Division of Network Medicine, Department of Medicine (L.Q.), Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115.
Joachim ThieryDepartment of Nutrition (Y.Z., F.M.S., L.Q.), Harvard T.H. Chan School of Public Health, Boston, Massachusetts 02115; Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics (U.C., J. T.), University Hospital-Leipzig, 04103 Leipzig, Germany; Department of Epidemiology, School of Public Health and Tropical Medicine (T.H., T.W., Y.H., L.Q.), Tulane University, New Orleans, Louisiana 70118; Department of Epidemiology, Saw Swee Hock School of Public Health (T.H.), National University of Singapore, Singapore 119077; Department of Epidemiology (W.M.), Harvard T.H. Chan School of Public Health, Boston, Massachusetts 02115; Pennington Biomedical Research Center (G.A.B.), Louisiana State University, Baton Rouge, Louisiana 70808; and Channing Division of Network Medicine, Department of Medicine (L.Q.), Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115.
Frank M SacksDepartment of Nutrition (Y.Z., F.M.S., L.Q.), Harvard T.H. Chan School of Public Health, Boston, Massachusetts 02115; Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics (U.C., J. T.), University Hospital-Leipzig, 04103 Leipzig, Germany; Department of Epidemiology, School of Public Health and Tropical Medicine (T.H., T.W., Y.H., L.Q.), Tulane University, New Orleans, Louisiana 70118; Department of Epidemiology, Saw Swee Hock School of Public Health (T.H.), National University of Singapore, Singapore 119077; Department of Epidemiology (W.M.), Harvard T.H. Chan School of Public Health, Boston, Massachusetts 02115; Pennington Biomedical Research Center (G.A.B.), Louisiana State University, Baton Rouge, Louisiana 70808; and Channing Division of Network Medicine, Department of Medicine (L.Q.), Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115.
Lu QiDepartment of Nutrition (Y.Z., F.M.S., L.Q.), Harvard T.H. Chan School of Public Health, Boston, Massachusetts 02115; Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics (U.C., J. T.), University Hospital-Leipzig, 04103 Leipzig, Germany; Department of Epidemiology, School of Public Health and Tropical Medicine (T.H., T.W., Y.H., L.Q.), Tulane University, New Orleans, Louisiana 70118; Department of Epidemiology, Saw Swee Hock School of Public Health (T.H.), National University of Singapore, Singapore 119077; Department of Epidemiology (W.M.), Harvard T.H. Chan School of Public Health, Boston, Massachusetts 02115; Pennington Biomedical Research Center (G.A.B.), Louisiana State University, Baton Rouge, Louisiana 70808; and Channing Division of Network Medicine, Department of Medicine (L.Q.), Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115.
Harvard University · USTulane University · USUniversity Hospital Leipzig · DENational University of Singapore · SGPennington Biomedical Research Center · US
Funding
Zoledronic Acid in Treatment of Osteoporosis in PostmenoM01RR002635 · NCRR · BRIGHAM AND WOMEN'S HOSPITAL · PI WILLIAMS, GORDON H · 1985 to 2008
$48.4MTransgenic CoreP30DK046200 · NIDDK · TUFTS MEDICAL CENTER · PI CORKEY, BARBARA E. · 1992 to 2021
$25.0MRISK FACTORS FOR CVD IN WOMENR01HL034594 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI JoAnn Elisabeth Manson, Lu Qi · 1985 to 2026
$13.8MDietary Macronutrients and Weight LossU01HL073286 · NHLBI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI SACKS, FRANK M · 2003 to 2008
$7.6MGenetic Markers of CHD in Type 2 DiabetesR01HL071981 · NHLBI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI QI, LU · 2003 to 2012
$4.9MObesity Genes, Energy Regulation in Response to Weight-Loss DietsR01DK091718 · NIDDK · TULANE UNIVERSITY OF LOUISIANA · PI QI, LU · 2012 to 2021
$4.5MWeight-Loss Diet Intervention on Cardiometabolic Factors of Gut MicrobiotaR01DK100383 · NIDDK · TULANE UNIVERSITY OF LOUISIANA · PI QI, LU · 2014 to 2024
$4.2MGenome-wide interactions with diet patterns on long-term weight changeR21HL126024 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI QI, LU · 2015 to 2016
$421kNCRR NIH HHS M01 RR002635NHLBI NIH HHS R01 HL034594NHLBI NIH HHS R01 HL071981NHLBI NIH HHS R21 HL126024NHLBI NIH HHS U01 HL073286NIDDK NIH HHS P30 DK046200NIDDK NIH HHS R01 DK091718NIDDK NIH HHS R01 DK100383
Abstract
contextTaurine metabolism disturbance is closely linked to obesity, insulin resistance, and diabetes. Previous evidence suggested that the preventative effects of taurine on diabetes might be through regulating the expression levels of diabetes-related genes.
objectiveWe estimated whether blood taurine levels modified the overall genetic susceptibility to diabetes on improvement of insulin sensitivity in a randomized dietary trial. DESIGN AND
settingWe genotyped 31 diabetes-associated variants to calculate a genetic risk score (GRS) and measured plasma taurine levels and glycemic traits among participants from the Preventing Overweight Using Novel Dietary Strategies (POUNDS Lost) trial.
participantsSeven-hundred eleven overweight or obese participants (age 30-70 y; 60% females) had genetic variants genotyped and blood taurine levels measured.
interventionParticipants went on 2-year weight-loss diets, which were different in macronutrient composition.
main outcome measureImprovements in glycemic traits were measured.
resultsWe found that baseline taurine levels significantly modified the effects of diabetes GRS on changes in fasting glucose, insulin, and homeostatic model assessment of insulin resistance (HOMA-IR) during the 2-year diet intervention (P-interaction = .04, .01, .002, respectively), regardless of weight loss. High baseline taurine levels were associated with a less reduction in both glucose and HOMA-IR among the participants with the lowest tertile of diabetes GRS (both P = .02), and with a greater reduction in both insulin and HOMA-IR among those with the highest tertile of diabetes GRS (both P = .04).
conclusionsOur data suggest that blood taurine levels might differentially modulate the effects of diabetes-related genes on improvement of insulin sensitivity among overweight/obese patients on weight-loss diets.
Indexed as
Genetic Predisposition to DiseaseInsulin ResistanceOutcome Assessment, Health CareAdultAgedDiabetes Mellitus, Type 2Diet, ReducingFemaleGenotypeHumansMaleMiddle AgedObesityOverweightRisk AssessmentTaurineTaurine
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.