SynthesisJournal of affective disorders2016
Depression and serum low-density lipoprotein: A systematic review and meta-analysis.
Synthesis in Journal of affective disorders, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
65 citing papers in PubMed, 3 syntheses or guidelines pooled it, 136 citations in OpenAlex.
- Physical Activity Promotes Health and Reduces Cardiovascular Mortality in Depressed Populations: A Literature Overview.International journal of environmental research and public health · 2020Pooled it
- Evidence-based umbrella review of 162 peripheral biomarkers for major mental disorders.Translational psychiatry · 2020Pooled it
- Metabolomics Profile in Depression: A Pooled Analysis of 230 Metabolic Markers in 5283 Cases With Depression and 10,145 Controls.Biological psychiatry · 2020Pooled it
- Trial
- PCSK9 at the intersection of lipid metabolism, immunometabolism, and psychiatric disorders: A narrative review.Brain, behavior, & immunity - health · 2026Review
- Metabolomic Profiling of Extracellular Vesicles Reveals Distinct Metabolic Dysregulation and Treatment-Specific Signatures in Depression.Biomolecules · 2026Article
- Association between Apolipoprotein B (ApoB) and suicidal ideation: a cross-sectional study and Mendelian randomization analysis.Annals of general psychiatry · 2026Article
- Article
- Machine Learning-Based Prediction of Antepartum Depression Symptoms: A Prospective Cohort Study.International journal of women's health · 2026Article
- Post-COVID-19: effects on mental health and metabolic markers in type 2 diabetes.Medicine and pharmacy reports · 2026Article
- Betel-quid Use Is Associated with Depression.International journal of medical sciences · 2026Article
- Association of higher triglyceride glucose index and triglyceride to high density lipoprotein cholesterol ratio with early-onset post-stroke depression.Scientific reports · 2025Article
- Associations of uric acid and lipids with depression, dimensions of depression and anxiety symptoms.Discover mental health · 2025Article
- Article
- Current Insight into Biological Markers of Depressive Disorder in Children and Adolescents: A Narrative Review.Antioxidants (Basel, Switzerland) · 2025Review
- Relationship Between Obesity and Depression Considering the Inflammatory Theory.International journal of molecular sciences · 2025Review
- Preferences of patients with depression for exercises: a discrete choice experiment.BMC public health · 2025Article
- Prevalence and determinants of depression and its association with social support among cancer patients: implications for enhancing oncology care.BMC psychology · 2025Article
- Association between remnant cholesterol and depression in middle-aged and older Chinese adults: a population-based cohort study.Frontiers in endocrinology · 2025Article
- Predictive factors and risk model for depression in patients with type 2 diabetes mellitus: a comprehensive analysis of comorbidities and clinical indicators.Frontiers in endocrinology · 2025Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
backgroundA cross-sectional association between depression and serum low-density lipoprotein (LDL) has been noted in the literature. This study aims to employ meta-analytic techniques to clarify the relationship between depression and serum LDL.
methodsPublished articles through April 2015 were identified through systematic query of PubMed with follow-up manual searches. Data from 36 studies reporting mean difference and 7 studies reporting odds ratios were analyzed separately.
resultsMeta-analysis of studies modeling serum LDL as a continuous measure demonstrates overall significantly lower serum LDL in depression (Mean difference=-4.29, 95% CI=-8.19, -0.40, p=0.03). Meta-analysis of studies modeling serum LDL as a categorical measure demonstrates a marginally significant lower odds of depression in the presence of low serum LDL relative to high serum LDL (OR=0.90, 95% CI=0.80, 1.01, p=0.08). LIMITATIONS: High heterogeneity was noted across sampled studies, which may be a function of variations in study design, participants sampled, or other factors. The potential for publication bias was also assessed.
conclusionsThis meta-analysis demonstrates a cross-sectional link between depression and low serum LDL.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.