Evidence map›Paper›PMID 27466616›Full record

ArticleOccupational and environmental medicine2016

Biomechanical and psychosocial exposures are independent risk factors for carpal tunnel syndrome: assessment of confounding using causal diagrams.

Carisa Harris-Adamson, Ellen A Eisen, Andreas Neophytou, Jay Kapellusch, Arun Garg, Kurt T Hegmann, Matthew S Thiese, Ann Marie Dale, Bradley Evanoff, Stephen Bao and 4 more

Open access · greenAbstract read
In one paragraph

Article in Occupational and environmental medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 38 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  5. Review
  6. Article
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  11. Adverse health manifestations in the hands of vibration exposed carpenters - a cross sectional study.Journal of occupational medicine and toxicology (London, England) · 2021
    Article
  12. Article
  13. Carpal Tunnel Syndrome: A National Survey to Monitor Knowledge and Operating Methods.International journal of environmental research and public health · 2021
    Article
  14. Article
  15. Article
  16. A Pilot Study of Five Types of Maximum Hand Strength among Manufacturing Industry Workers in Taiwan.International journal of environmental research and public health · 2019
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 8 institutions in 1 country.

Carisa Harris-AdamsonDivision of Occupational and Environmental Medicine, University of California, San Francisco, San Francisco, California, USA Department of Environmental Health Sciences, University of California Berkeley, Berkeley, California, USA.
Ellen A EisenDepartment of Environmental Health Sciences, University of California Berkeley, Berkeley, California, USA.
Andreas NeophytouDepartment of Environmental Health Sciences, University of California Berkeley, Berkeley, California, USA.ORCID http://orcid.org/0000-0001-7327-5361
Jay KapelluschCenter for Ergonomics, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin, USA.
Arun GargCenter for Ergonomics, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin, USA.
Kurt T HegmannRocky Mountain Center for Occupational and Environmental Health (RMCOEH), University of Utah, Salt Lake City, Utah, USA.
Matthew S ThieseRocky Mountain Center for Occupational and Environmental Health (RMCOEH), University of Utah, Salt Lake City, Utah, USA.
Ann Marie DaleDivision of General Medical Science, Washington University School of Medicine, Saint Louis, Missouri, USA.
Bradley EvanoffDivision of General Medical Science, Washington University School of Medicine, Saint Louis, Missouri, USA.
Stephen BaoWashington State Department of Labor and Industries, Safety and Health Assessment and Research for Prevention (SHARP) Program, Olympia, Washington, USA.
Barbara SilversteinWashington State Department of Labor and Industries, Safety and Health Assessment and Research for Prevention (SHARP) Program, Olympia, Washington, USA.
Fred GerrDepartment of Occupational and Environmental Health, University of Iowa, College of Public Health, Iowa City, Iowa, USA.
Susan Burtformerly with National Institute of Occupational Safety & Health, Atlanta, Georgia, USA.
David RempelDivision of Occupational and Environmental Medicine, University of California, San Francisco, San Francisco, California, USA Department of Bioengineering, University of California, Berkeley, Berkeley, California, USA.
United States Department of State · USUniversity of California, Berkeley · USUniversity of California, San Francisco · USUniversity of Utah · USUniversity of Wisconsin–Milwaukee · USWashington University in St. Louis · USNational Institute for Occupational Safety and Health · USUniversity of Iowa · US

Funding

Washington University Institute of Clinical and Translational SciencesUL1TR000448 · NCATS · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2012 to 2016
$41.4M
A Pooled Longitudinal Analysis of Workplace Carpal Tunnel SyndromeR01OH009712 · OH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI REMPEL, DAVID M · 2010 to 2012
$1.5M
NCATS NIH HHS UL1 TR000448NIOSH CDC HHS R01 OH009712
6 · The paper itself

Abstract

backgroundBetween 2001 and 2010, six research groups conducted coordinated prospective studies of carpal tunnel syndrome (CTS) incidence among US workers from various industries to estimate exposure-response relationships.

objectiveThis analysis examined the presence and magnitude of confounding between biomechanical and workplace psychosocial factors and incidence of dominant-hand CTS.

methods1605 participants, without CTS at enrolment, were followed for up to 3.5 years (2471 person-years). Demographic information, medical history and workplace psychosocial stress measures were collected at baseline. Individual workplace biomechanical exposures were collected for each task and combined across the workweek using time-weighted averaging (TWA). CTS case criteria were based on symptoms and results of electrophysiological testing. HRs were estimated with Cox proportional hazard models. Confounding was assessed using causal diagrams and an empirical criterion of 10% or greater change in effect estimate magnitude.

resultsThere were 109 incident CTS cases (IR=4.41/100 person-years; 6.7% cumulative incidence). The relationships between CTS and forceful repetition rate, % time forceful hand exertion and the Threshold Limit Value for Hand Activity Level (TLV-HAL) were slightly confounded by decision latitude with effect estimates being attenuated towards the null (10-14% change) after adjustment. The risk of CTS among participants reporting high job strain was attenuated towards the null by 14% after adjusting for the HAL Scale or the % time forceful hand exertions.

conclusionsAlthough attenuation of the relationships between CTS and some biomechanical and work psychosocial exposures was observed after adjusting for confounding, the magnitudes were small and confirmed biomechanical and work psychosocial exposures as independent risk factors for incident CTS.

Indexed as

AdultBiomechanical PhenomenaCarpal Tunnel SyndromeCausalityConfounding Factors, EpidemiologicFemaleHumansMaleMiddle AgedOccupational DiseasesOccupational ExposureProportional Hazards ModelsProspective StudiesRisk FactorsStress, PsychologicalSurveys and Questionnairesbiomechanical exposurecarpal tunnel syndromeconfoundingprospectivepsychosocial exposure

Identifiers

PMID27466616
PMCPMC6555409
OpenAlexW2485457305

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.