ArticleAnticancer research2016
DNA Repair Gene Expression Levels as Indicators of Breast Cancer in the Breast Cancer Family Registry.
Article in Anticancer research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 7 citations in OpenAlex.
- Mismatch Repair System Gene Expression in FFPE Samples from Breast Cancer Patients.Medical sciences (Basel, Switzerland) · 2025Article
- Air Pollution and Breast Cancer: An Examination of Modification By Underlying Familial Breast Cancer Risk.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2022Article
- Article
- Polymorphism of DNA Repair Genes via Homologous Recombination (HR) in Ovarian Cancer.Pathology oncology research : POR · 2019Article
- Circulating cell-free DNA release in vitro: kinetics, size profiling, and cancer-related gene methylation.Journal of cellular physiology · 2019Article
- Article
- A Preliminary Study: Human Fibroid Stro-1Reproductive sciences (Thousand Oaks, Calif.) · 2019Article
- Non-BRCA1/2 Breast Cancer Susceptibility Genes: A New Frontier with Clinical Consequences for Plastic Surgeons.Plastic and reconstructive surgery. Global open · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
aimThe expression level of DNA repair-related genes and their association with breast cancer status among participants of the New York site of the Breast Cancer Family Registry was investigated. MATERIALS AND
methodsRNA from mononuclear cells in 194 sister sets (n=475 women) were assayed for ATM, BRCA1, MSH2, MUTYH and XPC gene expression levels and analyzed using generalized estimating equations (GEE).
resultsIndividuals with decreased ATM and MSH2 expression had significantly higher odds for breast cancer compared to individuals with higher levels of expression (odds ratio (OR)=1.1, 95% confidence interval (CI)=1.02, 1.18) and (OR=1.90, 95% CI=1.21, 2.97), respectively. Upon stratifying the GEE model, reductions in ATM and MSH2 expression levels was heightened among women with an extended family history (FH) of breast cancer.
conclusionReduced expression of ATM and MSH2 compromises DNA repair capacity and, thereby, increases breast cancer prevalence.
Indexed as
Identifiers
27466510PMC5278521W2490248515What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.