Evidence map›Paper›PMID 27466471›Full record

ArticleNeurology2016

Genetic biomarkers for the risk of seizures in long QT syndrome.

David S Auerbach, Scott McNitt, Robert A Gross, Wojciech Zareba, Robert T Dirksen, Arthur J Moss

Erratum issuedOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 52 citations in OpenAlex.

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  11. Proceedings of the National Academy of Sciences of the United States of America · 2023
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  13. The ERG1 KFrontiers in molecular neuroscience · 2022
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

David S AuerbachFrom the Department of Medicine, Aab Cardiovascular Research Institute (D.S.A.), Department of Medicine, Heart Research Follow-up Program (S.M., W.Z., A.J.M.), and Departments of Neurology (R.A.G.) and Pharmacology & Physiology (R.A.G., R.T.D.), University of Rochester School of Medicine and Dentistry, Rochester, NY. david_auerbach@urmc.rochester.edu.
Scott McNittFrom the Department of Medicine, Aab Cardiovascular Research Institute (D.S.A.), Department of Medicine, Heart Research Follow-up Program (S.M., W.Z., A.J.M.), and Departments of Neurology (R.A.G.) and Pharmacology & Physiology (R.A.G., R.T.D.), University of Rochester School of Medicine and Dentistry, Rochester, NY.
Robert A GrossFrom the Department of Medicine, Aab Cardiovascular Research Institute (D.S.A.), Department of Medicine, Heart Research Follow-up Program (S.M., W.Z., A.J.M.), and Departments of Neurology (R.A.G.) and Pharmacology & Physiology (R.A.G., R.T.D.), University of Rochester School of Medicine and Dentistry, Rochester, NY.
Wojciech ZarebaFrom the Department of Medicine, Aab Cardiovascular Research Institute (D.S.A.), Department of Medicine, Heart Research Follow-up Program (S.M., W.Z., A.J.M.), and Departments of Neurology (R.A.G.) and Pharmacology & Physiology (R.A.G., R.T.D.), University of Rochester School of Medicine and Dentistry, Rochester, NY.
Robert T DirksenFrom the Department of Medicine, Aab Cardiovascular Research Institute (D.S.A.), Department of Medicine, Heart Research Follow-up Program (S.M., W.Z., A.J.M.), and Departments of Neurology (R.A.G.) and Pharmacology & Physiology (R.A.G., R.T.D.), University of Rochester School of Medicine and Dentistry, Rochester, NY.
Arthur J MossFrom the Department of Medicine, Aab Cardiovascular Research Institute (D.S.A.), Department of Medicine, Heart Research Follow-up Program (S.M., W.Z., A.J.M.), and Departments of Neurology (R.A.G.) and Pharmacology & Physiology (R.A.G., R.T.D.), University of Rochester School of Medicine and Dentistry, Rochester, NY.
University of Rochester · US

Funding

Training and Educational CoreU54NS048843 · NINDS · UNIVERSITY OF ROCHESTER · PI MOXLEY, RICHARD T · 2003 to 2017
$21.9M
RESEARCH TRAINING IN PREVENTIVE CARDIOLOGYT32HL007937 · NHLBI · UNIVERSITY OF ROCHESTER · PI LOWENSTEIN, CHARLES J · 2000 to 2014
$7.1M
LONG QT SYNDROME--POPULATION, GENETIC, &CARDIAC STUDIESR01HL033843 · NHLBI · UNIVERSITY OF ROCHESTER · PI MOSS, ARTHUR J. · 1985 to 2011
$5.9M
Clinical and Basic Science Studies in Long QT Syndrome Type 3R01HL123483 · NHLBI · UNIVERSITY OF ROCHESTER · PI KASS, ROBERT S, ZAREBA, WOJCIECH · 2014 to 2018
$3.7M
The University of Rochester Clinical and Translational Science InstituteKL2TR000095 · NCATS · UNIVERSITY OF ROCHESTER · PI BENNETT, NANCY M, KIEBURTZ, KARL D. · 2012 to 2015
$1.7M
LONG QT SYNDROME--GENETIC STUDIESR01HL051618 · NHLBI · UNIVERSITY OF ROCHESTER · PI MOSS, ARTHUR J. · 1993 to 2002
$1.2M
NCATS NIH HHS KL2 TR000095NHLBI NIH HHS R01 HL033843NHLBI NIH HHS R01 HL051618NHLBI NIH HHS R01 HL123483NHLBI NIH HHS T32 HL007937NINDS NIH HHS U54 NS048843
6 · The paper itself

Abstract

objectivesThe coprevalence, severity, and biomarkers for seizures and arrhythmias in long QT syndrome (LQTS) remain incompletely understood.

methodsUsing the Rochester-based LQTS Registry, this study included large cohorts of LQTS1-3 participants (LQTS

resultsCompared to LQTS

conclusionsThis study highlights potential biomarkers for neurocardiac electrical abnormalities in LQTS.

Indexed as

AdultCohort StudiesERG1 Potassium ChannelFemaleFollow-Up StudiesGenetic MarkersGenetic Predisposition to DiseaseHumansKCNQ1 Potassium ChannelLong QT SyndromeMaleMutationPrevalenceRegistriesRiskRisk FactorsERG1 Potassium ChannelGenetic MarkersKCNH2 protein, humanKCNQ1 Potassium ChannelKCNQ1 protein, human

Identifiers

PMID27466471
PMCPMC5085072
OpenAlexW2493762601

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.