ArticleProceedings. Biological sciences2016
Divergent evolution peaks under intermediate population bottlenecks during bacterial experimental evolution.
Article in Proceedings. Biological sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Virulent Parasites Emerge in Hosts With Rising Temperatures.Global change biology · 2026Article
- Novel continuous experimental evolution methodology uncovers rapid resistance development and cross-resistance.npj antimicrobials and resistance · 2026Article
- Translating eco-evolutionary biology into therapy to tackle antibiotic resistance.Nature reviews. Microbiology · 2023Review
- Population demographic history and evolutionary rescue: Influence of a bottleneck event.Evolutionary applications · 2023Article
- Mutators can drive the evolution of multi-resistance to antibiotics.PLoS genetics · 2023Article
- Evolutionary History and Strength of Selection Determine the Rate of Antibiotic Resistance Adaptation.Molecular biology and evolution · 2022Article
- Article
- Revisiting Antibiotic Resistance: Mechanistic Foundations to Evolutionary Outlook.Antibiotics (Basel, Switzerland) · 2021Review
- Evolutionary Dynamics of Asexual Hypermutators Adapting to a Novel Environment.Genome biology and evolution · 2021Article
- Bottleneck size and selection level reproducibly impact evolution of antibiotic resistance.Nature ecology & evolution · 2021Article
- Population Bottlenecks Strongly Affect the Evolutionary Dynamics of Antibiotic Persistence.Molecular biology and evolution · 2021Article
- Genomic basis of parallel adaptation varies with divergence inProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Ecology and molecular targets of hypermutation in the global microbiome.Nature communications · 2021Article
- Gene expression noise can promote the fixation of beneficial mutations in fluctuating environments.PLoS computational biology · 2020Article
- What can be learned by scanning the genome for molecular convergence in wild populations?Annals of the New York Academy of Sciences · 2020Review
- Efflux pump activity potentiates the evolution of antibiotic resistance across S. aureus isolates.Nature communications · 2020Article
- Larger bacterial populations evolve heavier fitness trade-offs and undergo greater ecological specialization.Heredity · 2020Article
- Population Bottlenecks Strongly Influence the Evolutionary Trajectory to Fluoroquinolone Resistance in Escherichia coli.Molecular biology and evolution · 2020Article
- Evolutionary Rescue of an EnvironmentalFrontiers in microbiology · 2020Article
- Disparate responses to salinity across species and organizational levels in anchialine shrimps.The Journal of experimental biology · 2019Article
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Authors and funding
4 authors.
Funding
Abstract
There is growing evidence that parallel molecular evolution is common, but its causes remain poorly understood. Demographic parameters such as population bottlenecks are predicted to be major determinants of parallelism. Here, we test the hypothesis that bottleneck intensity shapes parallel evolution by elucidating the genomic basis of adaptation to antibiotic-supplemented media in hundreds of populations of the bacterium Pseudomonas fluorescens Pf0-1. As expected, bottlenecking decreased the rate of phenotypic and molecular adaptation. Surprisingly, bottlenecking had no impact on the likelihood of parallel adaptive molecular evolution at a genome-wide scale. However, bottlenecking had a profound impact on the genes involved in antibiotic resistance. Specifically, under either intense or weak bottlenecking, resistance predominantly evolved by strongly beneficial mutations which provide high levels of antibiotic resistance. In contrast with intermediate bottlenecking regimes, resistance evolved by a greater diversity of genetic mechanisms, significantly reducing the observed levels of parallel genetic evolution. Our results demonstrate that population bottlenecking can be a major predictor of parallel evolution, but precisely how may be more complex than many simple theoretical predictions.
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