ArticlePoultry science2016
Thymus transcriptome reveals novel pathways in response to avian pathogenic Escherichia coli infection.
Article in Poultry science, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 37 citations in OpenAlex.
- Multi-Omics Unveils Inflammatory Regulation of Fermented Sini Decoction Dregs in Broilers Infected with Avian PathogenicVeterinary sciences · 2025Article
- Integrated Transcriptome Analysis Reveals the Lung miRNA-mRNA Regulatory Network Associated with Avian PathogenicVeterinary sciences · 2025Article
- Insights into the gut microbiota characteristics between the organic and traditional feeding chickens based on amplicon and metagenomic sequencing.Frontiers in microbiology · 2024Article
- Transcriptome alterations in chicken HD11 cells with steady knockdown and overexpression of RIPK2 gene.Poultry science · 2023Article
- Transcriptomic Analysis of the Spleen of Different Chicken Breeds Revealed the Differential Resistance ofGenes · 2022Article
- Gene expression profiling of RIP2-knockdown in HD11 macrophages - elucidation of potential pathways (gene network) when challenged with avian pathogenic E.coli (APEC).BMC genomics · 2022Article
- Transcriptional Regulation ofInternational journal of molecular sciences · 2022Article
- Article
- Analysis of circRNA expression in chicken HD11 cells in response to avian pathogenicFrontiers in veterinary science · 2022Article
- Genetic lines respond uniquely within the chicken thymic transcriptome to acute heat stress and low dose lipopolysaccharide.Scientific reports · 2019Article
- Concordant expression pattern across multiple immune tissues of commercial broilers in response to avian pathogenic3 Biotech · 2019Article
- Irf3 from mandarin fish thymus initiates interferon transcription.Fish physiology and biochemistry · 2019Article
- Article
- Messenger RNA Sequencing and Pathway Analysis Provide Novel Insights Into the Susceptibility toFrontiers in genetics · 2018Article
- What Makes the Harderian Gland Transcriptome Different From Other Chicken Immune Tissues? A Gene Expression Comparative Analysis.Frontiers in physiology · 2018Article
- Matrix-assisted laser desorption-ionization-time-of-flight mass spectrometry as a reliable proteomic method for characterization ofVeterinary world · 2017Article
- Deciphering alternative splicing and nonsense-mediated decay modulate expression in primary lymphoid tissues of birds infected with avian pathogenic E. coli (APEC).BMC genetics · 2017Article
- Novel MicroRNA Involved in Host Response to Avian Pathogenic Escherichia coli Identified by Deep Sequencing and Integration Analysis.Infection and immunity · 2017Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Avian pathogenic Escherichia coli (APEC) can cause significant morbidity in chickens. The thymus provides the essential environment for T cell development; however, the thymus transcriptome has not been examined for gene expression in response to APEC infection. An improved understanding of the host genomic response to APEC infection could inform future breeding programs for disease resistance and APEC control. We therefore analyzed the transcriptome of the thymus of birds challenged with APEC, contrasting susceptible and resistant phenotypes. Thousands of genes were differentially expressed in birds of the 5-day post infection (dpi) challenged-susceptible group vs. 5 dpi non-challenged, in 5 dpi challenged-susceptible vs. 5 dpi challenged-resistant birds, as well as in 5 dpi vs. one dpi challenged-susceptible birds. The Toll-like receptor signaling pathway was the major innate immune response for birds to respond to APEC infection. Moreover, lysosome and cell adhesion molecules pathways were common mechanisms for chicken response to APEC infection. The T-cell receptor signaling pathway, cell cycle, and p53 signaling pathways were significantly activated in resistant birds to resist APEC infection. These results provide a comprehensive assessment of global gene networks and biological functionalities of differentially expressed genes in the thymus under APEC infection. These findings provide novel insights into key molecular genetic mechanisms that differentiate host resistance from susceptibility in this primary lymphoid tissue, the thymus.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.