Evidence map›Paper›PMID 27466394›Full record

ArticleNucleic acids research2016

Translesion synthesis of O4-alkylthymidine lesions in human cells.

Jun Wu, Lin Li, Pengcheng Wang, Changjun You, Nicole L Williams, Yinsheng Wang

Open access · goldAbstract read
In one paragraph

Article in Nucleic acids research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 44 citations in OpenAlex.

  1. Article
  2. Article
  3. DNA polymerase κ participates in early S-phase DNA replication in human cells.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
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  5. Article
  6. Review
  7. Article
  8. DNA Alkylation Damage by Nitrosamines and Relevant DNA Repair Pathways.International journal of molecular sciences · 2023
    Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. LC-MS/MS for Assessing the Incorporation and Repair ofChemical research in toxicology · 2022
    Article
  14. Metabolic Activation and DNA Interactions of CarcinogenicInternational journal of molecular sciences · 2022
    Review
  15. Article
  16. Article
  17. DNA Polymerase η Promotes the Transcriptional Bypass ofJournal of the American Chemical Society · 2021
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Jun WuDepartment of Chemistry, University of California, Riverside, CA 92521-0403, USA.
Lin LiDepartment of Chemistry, University of California, Riverside, CA 92521-0403, USA.
Pengcheng WangEnvironmental Toxicology Graduate Program, University of California, Riverside, CA 92521-0403, USA.
Changjun YouDepartment of Chemistry, University of California, Riverside, CA 92521-0403, USA.
Nicole L WilliamsEnvironmental Toxicology Graduate Program, University of California, Riverside, CA 92521-0403, USA.
Yinsheng WangDepartment of Chemistry, University of California, Riverside, CA 92521-0403, USA Yinsheng.Wang@ucr.edu.
University of California, Riverside · US

Funding

Repair and Biological Consequences of Alkylated Thymidine LesionsR01ES025121 · NIEHS · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI WANG, YINSHENG · 2015 to 2019
$2.2M
NIEHS NIH HHS R01 ES025121
6 · The paper itself

Abstract

Environmental exposure, endogenous metabolism and cancer chemotherapy can give rise to alkylation of DNA, and the resulting alkylated thymidine (alkyldT) lesions were found to be poorly repaired and persistent in mammalian tissues. Unrepaired DNA lesions may compromise genomic integrity by inhibiting DNA replication and inducing mutations in these processes. In this study, we explored how eight O

Indexed as

DNA DamageDNA RepairDNA ReplicationAlkylationCRISPR-Cas SystemsDNA-Directed DNA PolymeraseGene EditingHEK293 CellsHumansMutationThymidineDNA-Directed DNA PolymeraseThymidine

Identifiers

PMID27466394
PMCPMC5100597
OpenAlexW2483485666

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.