ArticleInternational journal of epidemiology2016
Body fatness throughout the life course and the incidence of premenopausal breast cancer.
Article in International journal of epidemiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 3 syntheses or guidelines pooled it, 25 citations in OpenAlex.
- Dose response relationship between breast cancer and somatotypes during childhood: a systematic review and meta-analysis.British journal of cancer · 2023Pooled it
- Association of birth weight with cancer risk: a dose-response meta-analysis and Mendelian randomization study.Journal of cancer research and clinical oncology · 2023Pooled it
- Separating the effects of early and later life adiposity on colorectal cancer risk: a Mendelian randomization study.BMC medicine · 2023Pooled it
- Association of high birth weight with risk of early-onset colorectal cancer.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2026Article
- Body mass index at birth and early life and colorectal cancer: A two-sample Mendelian randomization analysis in European and East Asian genetic similarity populations.Pediatric obesity · 2025Article
- Separating the effects of life course adiposity on diabetic nephropathy: a comprehensive multivariable Mendelian randomization study.Frontiers in endocrinology · 2024Article
- Associations of height, body mass index, and weight gain with breast cancer risk in carriers of a pathogenic variant in BRCA1 or BRCA2: the BRCA1 and BRCA2 Cohort Consortium.Breast cancer research : BCR · 2023Article
- Birthweight, childhood body size, and timing of puberty and risks of breast cancer by menopausal status and tumor receptor subtypes.Breast cancer research : BCR · 2022Article
- Theory, methods, and operational results of the Young Women's Health History Study: a study of young-onset breast cancer incidence in Black and White women.Cancer causes & control : CCC · 2021Article
- Early-Life Body Adiposity and the Breast Tumor Transcriptome.Journal of the National Cancer Institute · 2021Article
- Body Habitus Across the Lifespan and Risk of Pituitary Adenoma.The Journal of clinical endocrinology and metabolism · 2021Article
- Body shape trajectories and risk of breast cancer: results from the SUN ('Seguimiento Universidad De Navarra') Project.Public health nutrition · 2021Article
- Maternal and Infant Anthropometric Characteristics and Breast Cancer Incidence in the Daughter.Scientific reports · 2020Article
- Breast Cancer and Nutrition: A Paradigm for Prevention in 3D Across the Life Course.Frontiers in oncology · 2020Article
- Do Birth Weight and Weight Gain During Infancy and Early Childhood Explain Variation in Mammographic Density in Women in Midlife? Results From Cohort and Sibling Analyses.American journal of epidemiology · 2019Article
- Prospective evaluation of body size and breast cancer risk among BRCA1 and BRCA2 mutation carriers.International journal of epidemiology · 2018Article
- Differential Patterns of Risk Factors for Early-Onset Breast Cancer by ER Status in African American Women.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2017Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe role of body fatness in the aetiology of breast cancer is complex. We evaluated the independent and synergistic effects of body fatness, at different stages throughout a woman's life course, on premenopausal breast cancer risk.
methodsPremenopausal participants of the Nurses' Health Study II (NHSII) were followed from 1991 up to 2009. Body fatness factors including birthweight, somatotype (a 9-level pictogram with level 1 being the leanest) at ages 5 and 10 years and body mass index (BMI) at age 18 were collected at baseline. Current BMI was updated biennially. Multivariate Cox regression models were used to evaluate the association between each body fatness factor as well as cross-classification of all factors and the incidence of breast cancer.
resultsBased on 1574 incident premenopausal breast cancer cases and 1 133 893 person-years of follow-up, a lower incidence was associated with lower birthweight: hazard ratio (HR) [95% confidence interval (CI)] = 0.74 (0.58-0.95) for <2.5kg vs 3.9+kg, P for trend < 0.001; higher somatotype at age 5: HR=0.57 (95% CI 0.44-0.73) for 5-9 vs 1, P fortrend < 0.0001]; and at age 10: HR=0.61 (95% CI 0.49-0.75) for 5-9 vs 1, P for trend < 0.0001]; and BMI at age 18: HR=0.67 (95% 0.47-0.95) for ≥ 27.5 kg/m
conclusionThe lowest incidence of premenopausal breast cancer was associated with the lowest birthweight and the highest childhood, adolescent and early adult body fatness.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.