ArticleBMJ open2016
Patterns of weight change after the diagnosis of type 2 diabetes in Scotland and their relationship with glycaemic control, mortality and cardiovascular outcomes: a retrospective cohort study.
Article in BMJ open, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 6 of them syntheses that pooled it.
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Who cites it
36 citing papers in PubMed, 6 syntheses or guidelines pooled it, 63 citations in OpenAlex.
- Weight variability and cardiovascular outcomes: a systematic review and meta-analysis.Cardiovascular diabetology · 2023Pooled it
- Association of magnitude of weight loss and weight variability with mortality and major cardiovascular events among individuals with type 2 diabetes mellitus: a systematic review and meta-analysis.Cardiovascular diabetology · 2022Pooled it
- Pooled it
- Metabolic effects of antihyperglycemic agents and mortality: meta-analysis of randomized controlled trials.Scientific reports · 2020Pooled it
- Body-Weight Fluctuation Was Associated With Increased Risk for Cardiovascular Disease, All-Cause and Cardiovascular Mortality: A Systematic Review and Meta-Analysis.Frontiers in endocrinology · 2019Pooled it
- Weight loss increases all-cause mortality in overweight or obese patients with diabetes: A meta-analysis.Medicine · 2018Pooled it
- Estimating the Clinical, Quality-of-Life and Economic Impact of Optimized Management of Type 2 Diabetes Patients in Spain.Journal of clinical medicine · 2026Article
- Weight Trajectory Impacts Risk for 10 Distinct Cardiometabolic Diseases.The Journal of clinical endocrinology and metabolism · 2025Article
- Association of Long-Term Body Mass Index Variability With the Development of Heart Failure With Preserved Ejection Fraction and Heart Failure With Reduced Ejection Fraction Across Patterns of Weight Change.Journal of the American Heart Association · 2025Article
- Trajectories of BMI before and after diagnosis of type 2 diabetes in a real-world population.Diabetologia · 2024Observational
- BMI variability and cardiovascular outcomes within clinical trial and real-world environments in type 2 diabetes: an IMI2 SOPHIA study.Cardiovascular diabetology · 2024Observational
- Weight Change and the Risk of Micro and Macro Vascular Complications of Diabetes: A Systematic Review.The Malaysian journal of medical sciences : MJMS · 2024Review
- Glycemic Control and Obesity Among People With Type 2 Diabetes in Europe and Australia: A Retrospective Cohort Analysis.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2024Article
- Effect of a two-only-meals-a-day and exercise lifestyle on HbA1c and anti-diabetic medication in a follow-up study of subjects with type 2 diabetes attending a free clinic in a north Maharashtra city.Journal of family medicine and primary care · 2024Article
- Trajectories of Body Mass Index and Risk for Diabetes Complications and All-Cause Mortality in Finnish Type 2 Diabetes Patients.Clinical epidemiology · 2024Article
- Effects of Weight Loss and Interaction with Physical Activity on Risks of Cardiovascular Outcomes in Individuals with Type 2 Diabetes.Endocrinology and metabolism (Seoul, Korea) · 2023Article
- Susceptibility of Human Plasma N-glycome to Low-Calorie and Different Weight-Maintenance Diets.International journal of molecular sciences · 2022Article
- Type 2 Diabetes Incidence and Mortality: Associations with Physical Activity, Fitness, Weight Loss, and Weight Cycling.Reviews in cardiovascular medicine · 2022Review
- Weight Changes in Type 2 Diabetes and Cancer Risk: A Latent Class Trajectory Model Study.Obesity facts · 2022Article
- Body-mass index and diabetes risk in 57 low-income and middle-income countries: a cross-sectional study of nationally representative, individual-level data in 685 616 adults.Lancet (London, England) · 2021Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
objectivesTo determine weight change patterns in Scottish patients 2 years after diagnosis of type 2 diabetes and to examine these in association with medium-term glycaemic, mortality and cardiovascular outcomes.
settingUsing a retrospective cohort design, ethical approval was obtained to link the Scottish diabetes care database to hospital admission and mortality records.
participants29 316 overweight/obese patients with incident diabetes diagnosed between 2002 and 2006 were identified with relevant information for ≥2 years. PRIMARY AND SECONDARY OUTCOME MEASURES: Weight records over time provided intrapatient weight change and variation and glycated haemoglobin (HbA1c) gave measures of glycaemic control. These characteristics and demographic variables at diagnosis were linked with notifications of death (2-5 years after diagnosis) and cardiovascular events (0-5 year after diagnosis).
resultsBy 2 years, 36% of patients had lost ≥2.5% of their weight. Increasing age, being female and a higher body mass index at diagnosis were associated with larger proportions of weight lost (p<0.001). Multivariable modelling showed that inadequate glycaemic control at 2 years was associated with being younger at baseline, being male, having lower levels of obesity at diagnosis, gaining weight or being weight stable with weight change variability, and starting antidiabetic medication. While weight change itself was not related to mortality or cardiovascular outcomes, major weight variability was independently associated with poorer survival and increased cardiovascular outcome risks, as was deprivation.
conclusionsOur results suggest that weight loss or being weight stable with little weight variability early after diabetes diagnosis, are associated with better glycaemic control and we identified groups less able to lose weight. With respect to mortality and cardiovascular outcomes, although weight change at 2 years was a weak predictor, major weight variability appeared to be the more relevant factor.
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Registered trials
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