ArticleScientific reports2016
Molecular developmental mechanism in polypterid fish provides insight into the origin of vertebrate lungs.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Assembly of a high-quality Polypterus senegalus diploid genome.Genes & genomics · 2025Article
- The inbred newt genome unveils molecular mechanisms of behavior, development, and regeneration in urodele amphibians.iScience · 2025Article
- Analysis of a shark reveals ancient, Wnt-dependent, habenular asymmetries in vertebrates.Nature communications · 2024Article
- The Evolution of Ultraconserved Elements in Vertebrates.Molecular biology and evolution · 2024Article
- Reciprocal Interactions Between the Epithelium and Mesenchyme in Organogenesis.Results and problems in cell differentiation · 2024Article
- Protein-protein interaction network module changes associated with the vertebrate fin-to-limb transition.Scientific reports · 2023Article
- Fish hearing revealed: Do we understand hearing in critical fishes and marine tetrapods.The Journal of the Acoustical Society of America · 2023Article
- Expanded olfactory system in ray-finned fishes capable of terrestrial exploration.BMC biology · 2023Article
- The evolution of the various structures required for hearing inIBRO neuroscience reports · 2023Article
- Plastic loss of motile cilia in the gills ofEcology and evolution · 2023Article
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- The bowfin genome illuminates the developmental evolution of ray-finned fishes.Nature genetics · 2021Article
- Changes in Nkx2.1, Sox2, Bmp4, and Bmp16 expression underlying the lung-to-gas bladder evolutionary transition in ray-finned fishes.Evolution & development · 2020Article
- Dorsoventral inversion of the air-filled organ (lungs, gas bladder) in vertebrates: RNAsequencing of laser capture microdissected embryonic tissue.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2020Article
- Bichir external gills arise via heterochronic shift that accelerates hyoid arch development.eLife · 2019Article
- Article
- Evolutionarily conservedProceedings of the National Academy of Sciences of the United States of America · 2018Article
- Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.Nature ecology & evolution · 2018Article
- Inference of the ancestral vertebrate phenotype through vestiges of the whole-genome duplications.Briefings in functional genomics · 2018Review
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Authors and funding
7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The lung is an important organ for air breathing in tetrapods and originated well before the terrestrialization of vertebrates. Therefore, to better understand lung evolution, we investigated lung development in the extant basal actinopterygian fish Senegal bichir (Polypterus senegalus). First, we histologically confirmed that lung development in this species is very similar to that of tetrapods. We also found that the mesenchymal expression patterns of three genes that are known to play important roles in early lung development in tetrapods (Fgf10, Tbx4, and Tbx5) were quite similar to those of tetrapods. Moreover, we found a Tbx4 core lung mesenchyme-specific enhancer (C-LME) in the genomes of bichir and coelacanth (Latimeria chalumnae) and experimentally confirmed that these were functional in tetrapods. These findings provide the first molecular evidence that the developmental program for lung was already established in the common ancestor of actinopterygians and sarcopterygians.
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