ArticleHuman brain mapping2016
Disrupted structural and functional rich club organization of the brain connectome in patients with generalized tonic-clonic seizure.
Article in Human brain mapping, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- A systematic review of global signal topography in aging, neuropsychiatric disorders, and cognitive task performance.Brain imaging and behavior · 2026Pooled it
- Disrupted rich club organization in structural brain networks is related to childhood maltreatment in major depressive disorder.Frontiers in psychiatry · 2026Article
- Normative structural connectome constrains spreading transient brain activity in generalized epilepsy.BMC medicine · 2025Article
- The network neuropsychology of juvenile myoclonic epilepsy.Cortex; a journal devoted to the study of the nervous system and behavior · 2025Article
- Age-Specific Functional Connectivity Changes After Partial Sleep Deprivation Are Correlated With Neurocognitive and Molecular Signatures.CNS neuroscience & therapeutics · 2025Article
- Abnormal static and dynamic functional network connectivity of the whole-brain in children with generalized tonic-clonic seizures.Frontiers in neuroscience · 2023Article
- Aberrant dynamic structure-function relationship of rich-club organization in treatment-naïve newly diagnosed juvenile myoclonic epilepsy.Human brain mapping · 2022Article
- Normalization effect of levodopa on hierarchical brain function in Parkinson's disease.Network neuroscience (Cambridge, Mass.) · 2022Article
- The Local Topological Reconfiguration in the Brain Network After Targeted Hub Dysfunction Attacks in Patients With Juvenile Myoclonic Epilepsy.Frontiers in neuroscience · 2022Article
- Impaired Functional Homotopy and Topological Properties Within the Default Mode Network of Children With Generalized Tonic-Clonic Seizures: A Resting-State fMRI Study.Frontiers in neuroscience · 2022Article
- Volumetric and structural connectivity abnormalities co-localise in TLE.NeuroImage. Clinical · 2022Article
- Reconfiguration of static and dynamic thalamo-cortical network functional connectivity of epileptic children with generalized tonic-clonic seizures.Frontiers in neuroscience · 2022Article
- Shared and distinct global signal topography disturbances in subcortical and cortical networks in human epilepsy.Human brain mapping · 2021Article
- Disrupted topological properties of functional networks in epileptic children with generalized tonic-clonic seizures.Brain and behavior · 2020Article
- Cognitive deficits and white matter abnormalities in never-treated first-episode schizophrenia.Translational psychiatry · 2020Article
- Contributions of Imaging to Neuromodulatory Treatment of Drug-Refractory Epilepsy.Brain sciences · 2020Review
- Rich-club in the brain's macrostructure: Insights from graph theoretical analysis.Computational and structural biotechnology journal · 2020Review
- Impaired Topological Properties of Gray Matter Structural Covariance Network in Epilepsy Children With Generalized Tonic-Clonic Seizures: A Graph Theoretical Analysis.Frontiers in neurology · 2020Article
- Enhancement of indirect functional connections with shortest path length in the adult autistic brain.Human brain mapping · 2019Article
- Critical synchronization and 1/f noise in inhibitory/excitatory rich-club neural networks.Scientific reports · 2019Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Network studies have demonstrated that a small set of highly connected regions may play a central role in global information integration, together forming a rich club organization. Given that generalized tonic-clonic seizure (GTCS) has been conceptualized as a network disorder, we hypothesized that the rich club disturbances may be related to the network abnormalities of GTCS. Here, we used graph theoretical analysis to investigate the rich club organization of both structural and functional connectome in patients with GTCS (n = 50) and healthy controls (n = 60). We further measured the level of global efficiency and clustering in rich club and non-rich club organization. We, respectively, identified a small number of highly connected hubs as rich club organization from structural and functional networks. Patients were found to exhibit significantly reduced rich club connectivity among the central hubs. Meanwhile, both structural and functional network showed changed levels of global efficiency and clustering of rich club organization in GTCS. Furthermore, in patients, lower levels of rich club connectivity were found to be correlated with longer duration of illness and seizure frequency. Together, these findings suggest that GTCS is characterized by a selective disruption of rich club organization due to the long-term injurious effects of epileptic actions on the central hub regions, which potentially contribute to a reduced level of brain integration capacity among different functional domains and an added effect of illness on a preexisting vulnerability. Our findings emphasize a central role for abnormal rich club organization in the pathophysiological mechanism underlying GTCS. Hum Brain Mapp 37:4487-4499, 2016. © 2016 Wiley Periodicals, Inc.
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