ArticleAnesthesiology2016
Raman Spectroscopy Differentiates Each Tissue from the Skin to the Spinal Cord: A Novel Method for Epidural Needle Placement?
Article in Anesthesiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 21 citations in OpenAlex.
- Swept-source Raman spectroscopy of chemical and biological materials.Journal of biomedical optics · 2024Article
- Enhancing epidural needle guidance using a polarization-sensitive optical coherence tomography probe with convolutional neural networks.Journal of biophotonics · 2024Article
- Stomach tissue classification using autofluorescence spectroscopy and machine learning.Surgical endoscopy · 2023Article
- Epidural anesthesia needle guidance by forward-view endoscopic optical coherence tomography and deep learning.Scientific reports · 2022Article
- Analysis of subcutaneous swine fat via deep Raman spectroscopy using a fiber-optic probe.The Analyst · 2020Article
- A resistance-sensing mechanical injector for the precise delivery of liquids to target tissue.Nature biomedical engineering · 2019Article
- Three-Dimensional Ultrasonic Needle Tip Tracking with a Fiber-Optic Ultrasound Receiver.Journal of visualized experiments : JoVE · 2018Article
- Smart Optical Catheters for Epidurals.Sensors (Basel, Switzerland) · 2018Article
- Looking beyond the imaging plane: 3D needle tracking with a linear array ultrasound probe.Scientific reports · 2017Article
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Authors and funding
5 authors at 1 institution in 3 countries.
Funding
Abstract
backgroundNeuraxial anesthesia and epidural steroid injection techniques require precise anatomical targeting to ensure successful and safe analgesia. Previous studies suggest that only some of the tissues encountered during these procedures can be identified by spectroscopic methods, and no previous study has investigated the use of Raman, diffuse reflectance, and fluorescence spectroscopies. The authors hypothesized that real-time needle-tip spectroscopy may aid epidural needle placement and tested the ability of spectroscopy to distinguish each of the tissues in the path of neuraxial needles.
methodsFor comparison of detection methods, the spectra of individual, dissected ex vivo paravertebral and neuraxial porcine tissues were collected using Raman spectroscopy (RS), diffuse reflectance spectroscopy, and fluorescence spectroscopy. Real-time spectral guidance was tested using a 2-mm inner-diameter fiber-optic probe-in-needle device. Raman spectra were collected during the needle's passage through intact paravertebral and neuraxial porcine tissue and analyzed afterward. The RS tissue signatures were verified as mapping to individual tissue layers using histochemical staining and widefield microscopy.
resultsRS revealed a unique spectrum for all ex vivo paravertebral and neuraxial tissue layers; diffuse reflectance spectroscopy and fluorescence spectroscopy were not distinct for all tissues. Moreover, when accounting for the expected order of tissues, real-time Raman spectra recorded during needle insertion also permitted identification of each paravertebral and neuraxial porcine tissue.
conclusionsThis study demonstrates that RS can distinguish the tissues encountered during epidural needle insertion. This technology may prove useful during needle placement by providing evidence of its anatomical localization.
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