ArticleJournal of human hypertension2017
Serum uric acid is an independent predictor for developing prehypertension: a population-based prospective cohort study.
Article in Journal of human hypertension, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Impact of Hyperuricemia on Incident Hypertension When Hypertension Definition Changes From 140/90 to 130/80 mmHg in a Large Taiwanese Population Follow-Up Study.Journal of clinical hypertension (Greenwich, Conn.) · 2025Observational
- Arterial stiffness and biochemical profiles in prehypertensive, normotensive, and controlled hypertensive individuals: a cross-sectional study.Frontiers in cardiovascular medicine · 2025Article
- Associations of serum uric acid trajectories with hypertension risk: exploring differences between age groups.Frontiers in cardiovascular medicine · 2025Article
- Urate Levels as a Predictor of the Prevalence and Level of Cardiovascular Risk Factors: An Identificación de La PoBlación Española de Riesgo Cardiovascular y Renal Study.Biomolecules · 2024Article
- The Association between Uric Acid and Metabolic Syndrome in a Middle-Aged and Elderly Taiwanese Population: A Community-Based Cross-Sectional Study.Healthcare (Basel, Switzerland) · 2024Article
- A Cohort Study on the Correlation Between Serum Uric Acid Trajectory and New-Onset Hypertension Based on Longitudinal Health Examination Data in Henan Area.Journal of inflammation research · 2024Article
- Decompression Mechanism of Radish Seed in Prehypertension Rats through Integration of Transcriptomics and Metabolomics Methods.Evidence-based complementary and alternative medicine : eCAM · 2023Article
- Prevalence of Hyperuricemia and Its Association with Cardiovascular Risk Factors and Subclinical Target Organ Damage.Journal of clinical medicine · 2022Article
- Article
- Baseline and change in serum uric acid predict the progression from prehypertension to hypertension: a prospective cohort study.Journal of human hypertension · 2022Article
- Prevalence, patterns and predictors of metabolic abnormalities in Nigerian hypertensives with hypertriglyceridemic waist phenotype: A cross sectional study.PLOS global public health · 2022Article
- Association between Serum Uric Acid and Pre-hypertension and Hypertension among Chinese Adults.Arquivos brasileiros de cardiologia · 2021Article
- U-Shaped Relationship Between Cardiovascular Mortality and Serum Uric Acid May Be Attributed to Stroke- and Heart-Specific Mortality, Respectively, Among Hypertensive Patients: A Nationally Representative Cohort Study.Medical science monitor : international medical journal of experimental and clinical research · 2021Article
- The effect of uric acid and urinary sodium excretion on prehypertension: a nationwide population-based study.BMC cardiovascular disorders · 2020Article
- Hyperuricemia and Risk of Cardiovascular Outcomes: The Experience of the URRAH (Uric Acid Right for Heart Health) Project.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2020Review
- Hyperuricemia and Hypertension: Links and Risks.Integrated blood pressure control · 2019Review
- Association between urinary sodium excretion and uric acid, and its interaction on the risk of prehypertension among Chinese young adults.Scientific reports · 2018Article
- Relationship of serum immunoglobulin levels to blood pressure and hypertension in an adult population.Journal of human hypertension · 2018Article
- Uric Acid Is a Strong Risk Marker for Developing Hypertension From Prehypertension: A 5-Year Japanese Cohort Study.Hypertension (Dallas, Tex. : 1979) · 2018Article
Corrections and comments
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Authors and funding
26 authors.
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Abstract
Although the prevalence of prehypertension is rapidly increasing in China, the medical community has paid little attention to its prevention. Prior studies have demonstrated that uric acid directly contributes to vascular remodelling and endothelial dysfunction. However, few prospective studies have assessed the relationship between serum uric acid and prehypertension. We therefore designed a larger-scale cohort study to examine whether uric acid level is a predictive factor for developing prehypertension in adults. Participants were recruited from Tianjin Medical University General Hospital-Health Management Centre. A prospective assessment (n=15 143) was performed. Participants without a history of hypertension or prehypertension were followed up for 2 to 6 years with a median follow-up duration of 2.8 years. Serum uric acid levels and blood pressure were assessed yearly during the follow-up. Adjusted Cox proportional hazards regression models were used to assess relationships between the quintiles of uric acid levels and the incidence of prehypertension. The incidence of prehypertension was 191 per 1000 person-years. In the final multivariate models, the hazard ratios (95% confidence interval) for prehypertension across uric acid quintiles were 1.00 (reference), 0.98 (0.90-1.07), 1.01 (0.93-1.10), 1.09 (1.001-1.20) and 1.17 (1.06-1.29) (P for trend <0.001), respectively. This population-based prospective cohort study has demonstrated that uric acid level is an independent predictor for developing prehypertension.
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