Evidence map›Paper›PMID 27465935›Full record

ArticleObesity surgery2017

Effect of Laparoscopic Sleeve Gastrectomy on Fasting Gastrointestinal, Pancreatic, and Adipose-Derived Hormones and on Non-Esterified Fatty Acids.

John E Farey, Tamara C Preda, Oliver M Fisher, Angelique J Levert-Mignon, Rebecca L Stewart, Elisabeth Karsten, Benjamin R Herbert, Michael M Swarbrick, Reginald V Lord

Registry-linked trialOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Obesity surgery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03851874 (A Comparative Study of the Effects of Roux en Y Gastric Bypass and Sleeve Gastrectomy on Postprandial Gut Hormone Responses, Glycemia and Lipid Profile, Weight Loss, and Indices of Cardiovascular Risk), which is not on this map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
5.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03851874 nacompletednot on this map

A Comparative Study of the Effects of Roux en Y Gastric Bypass and Sleeve Gastrectomy on Postprandial Gut Hormone Responses, Glycemia and Lipid Profile, Weight Loss, and Indices of Cardiovascular Risk

TypeinterventionalSponsorNational and Kapodistrian University of AthensRan2011 to 2014Enrolled28ConditionsMorbid ObesityArmsBariatric surgery
3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.

  1. Pooled it
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  11. Serum free fatty acid levels and insulin resistance in patients undergoing one-anastomosis gastric bypass.Wideochirurgia i inne techniki maloinwazyjne = Videosurgery and other miniinvasive techniques · 2022
    Article
  12. Rates, Risks, and Time to Fracture in Patients Undergoing Laparoscopic Vertical Sleeve Gastrectomy versus Roux-en-Y Gastric Bypass.Annals of surgery open : perspectives of surgical history, education, and clinical approaches · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

John E FareyDepartment of Surgery, School of Medicine, University of Notre Dame, Sydney, New South Wales, Australia.
Tamara C PredaDepartment of Surgery, School of Medicine, University of Notre Dame, Sydney, New South Wales, Australia.
Oliver M FisherDepartment of Surgery, School of Medicine, University of Notre Dame, Sydney, New South Wales, Australia.
Angelique J Levert-MignonGastro-oesophageal Cancer Research Program, St Vincent's Centre for Applied Medical Research, Suite 606, 438 Victoria Street, Darlinghurst, Sydney, NSW, 2010, Australia.
Rebecca L StewartDiabetes and Metabolism Division, Garvan Institute of Medical Research, Darlinghurst, Sydney, Australia.
Elisabeth KarstenBiomolecular Frontiers Centre, Department of Chemistry and Biomolecular Science, Faculty of Science, Macquarie University, Sydney, Australia.
Benjamin R HerbertBiomolecular Frontiers Centre, Department of Chemistry and Biomolecular Science, Faculty of Science, Macquarie University, Sydney, Australia.
Michael M SwarbrickDiabetes and Metabolism Division, Garvan Institute of Medical Research, Darlinghurst, Sydney, Australia.
Reginald V LordDepartment of Surgery, School of Medicine, University of Notre Dame, Sydney, New South Wales, Australia. rvlord@stvincents.com.au.
The University of Notre Dame Australia · AUMacquarie University · AUGarvan Institute of Medical Research · AUUNSW Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAlterations in gastrointestinal, pancreatic, and adipose hormone levels may have a greater role in weight loss than initially appreciated. The laparoscopic sleeve gastrectomy (LSG) operation is now the most frequently performed bariatric operation in many countries, but there are relatively few data regarding its molecular effects. We sought to characterize the effect of LSG on fasting plasma levels of selected hormones and on non-esterified fatty acids (NEFA), and to compare these to levels in non-obese control individuals. MATERIALS AND

methodsThe levels of nine plasma hormones were measured using a multiplex bead-based assay at baseline and at 3 months after operation in 11 obese patients undergoing LSG. NEFA levels were also measured. The levels were compared to those for 22 age- and sex-matched non-obese individuals.

resultsAt baseline, obese patients showed significantly higher expression of C-peptide, insulin, and leptin and significantly lower ghrelin, glucose-dependent insulinotropic peptide (GIP), and resistin compared to non-obese controls (p < 0.05). LSG resulted in a reduction in BMI from 42.5 ± 6.47 kg/m

conclusionLSG induces marked early changes in the fasting levels of factors thought to be important regulators of obesity and metabolic health. These changes differ somewhat from the findings for operations with a malabsorptive component, suggesting that subtle differences exist in the mechanisms of weight loss between LSG and other bariatric operations.

Indexed as

GastrectomyAdipokinesAdiposityAdultAgedCase-Control StudiesFastingFatty Acids, NonesterifiedFemaleGastrointestinal HormonesHumansMaleMiddle AgedObesity, MorbidPancreatic HormonesWeight LossAdipokinesFatty Acids, NonesterifiedGastrointestinal HormonesPancreatic HormonesBariatric surgeryC-peptideGhrelinGIPGLP-1GlucagonInsulinLeptinNEFAPAI-1ResistinSleeve gastrectomyWeight loss

Identifiers

PMID27465935
PMCPMC5237658
OpenAlexW2485186915

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.