ArticleObesity (Silver Spring, Md.)2016
Changes in regional body composition over 8 years in a randomized lifestyle trial: The look AHEAD study.
Article in Obesity (Silver Spring, Md.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Associations between decreases in adiposity and reductions in HbA1c and insulin use in the Look AHEAD cohort.Obesity (Silver Spring, Md.) · 2025Trial
- Long-term sustained effects of the Look AHEAD lifestyle intervention on body composition among adults with type 2 diabetes.Obesity (Silver Spring, Md.) · 2024Trial
- Association of cognition with leptin and vascular endothelial growth factor in individuals with type 2 diabetes mellitus.Obesity (Silver Spring, Md.) · 2022Trial
- Trial
- Impact of Multidomain Lifestyle Intervention on Frailty Through the Lens of Deficit Accumulation in Adults with Type 2 Diabetes Mellitus.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020Trial
- Long Term Effect of Intensive Lifestyle Intervention on Cerebral Blood Flow.Journal of the American Geriatrics Society · 2018Trial
- Beyond Weight Loss: Skeletal Muscle Health During Incretin-Based Therapy in Patients with Diabesity.Nutrients · 2026Review
- Role of Sex Hormones in Mediating Adiposity Changes From Weight Loss in People With Type 2 Diabetes: Look AHEAD Sex Hormone Study.The Journal of clinical endocrinology and metabolism · 2025Article
- Adaptive thermogenesis driving catch-up fat during weight regain: a role for skeletal muscle hypothyroidism and a risk for sarcopenic obesity.Reviews in endocrine & metabolic disorders · 2025Review
- Heterogeneity of effect of Intensive lifestyle intervention on cardiometabolic risk factors by sex hormones in diabetes.medRxiv : the preprint server for health sciences · 2025Article
- Impact of GLP- 1 Receptor Agonist Therapy in Patients High Risk for Sarcopenia.Current nutrition reports · 2025Review
- Incretin-based therapies for the management of cardiometabolic disease in the clinic: Past, present, and future.Medicinal research reviews · 2025Review
- Strategies for minimizing muscle loss during use of incretin-mimetic drugs for treatment of obesity.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2025Review
- Review
- Mechanisms of action and therapeutic applications of GLP-1 and dual GIP/GLP-1 receptor agonists.Frontiers in endocrinology · 2024Review
- Body composition changes in diabetes and aging.Journal of diabetes and its complications · 2019Review
- Cross-Sectional and Longitudinal Association between Glycemic Status and Body Composition in Men: A Population-Based Study.Nutrients · 2018Article
- Relationship Between Changes in Fat and Lean Depots Following Weight Loss and Changes in Cardiovascular Disease Risk Markers.Journal of the American Heart Association · 2018Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
objectiveTo test the hypothesis that an 8-year intensive lifestyle intervention (ILI) suppresses aging-dependent changes in regional lean mass (LM) and fat mass (FM) among people with overweight/obesity and type 2 diabetes.
methodsRegional body composition was measured by dual-energy X-ray absorptiometry within a subset of 1,019 volunteers (45-75 years old) in the Look AHEAD study randomized to ILI or diabetes support and education (DSE). The ILI goal was to achieve and maintain ≥7% weight loss through increased physical activity and reduced caloric intake.
resultsOver 8 years, the DSE group exhibited a linear loss of LM and FM. During year 1, the ILI group lost LM and FM. Between years 1 and 8, the ILI group regained most FM in all regions; regional LM converged with that of the DSE group; the percent of LM loss was greater for the leg than for the trunk. Among both groups, regional LM and FM change was proportional to the size of the region, trunk > leg > arm.
conclusionsAging-dependent LM losses, particularly in the leg region, were not suppressed by ILI. The long-term consequences of rapid LM and FM loss and subsequent regain mostly as fat are unknown.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.