ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2016
Loss of REDD1 augments the rate of the overload-induced increase in muscle mass.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 27 citations in OpenAlex.
- Mifepristone alone and in combination with scAAV9-SMN1 gene therapy improves disease phenotypes in SmnScientific reports · 2025Article
- Contractile regulation of the glucocorticoid-sensitive transcriptome in young and aged skeletal muscle.American journal of physiology. Endocrinology and metabolism · 2024Article
- Mechanisms of mechanical overload-induced skeletal muscle hypertrophy: current understanding and future directions.Physiological reviews · 2023Review
- The duration of glucocorticoid treatment alters the anabolic response to high-force muscle contractions.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- Senolytic treatment rescues blunted muscle hypertrophy in old mice.GeroScience · 2022Article
- Loss of REDD1 prevents chemotherapy-induced muscle atrophy and weakness in mice.Journal of cachexia, sarcopenia and muscle · 2021Article
- A clinically relevant decrease in contractile force differentially regulates control of glucocorticoid receptor translocation in mouse skeletal muscle.Journal of applied physiology (Bethesda, Md. : 1985) · 2021Article
- Androgen depletion alters the diurnal patterns to signals that regulate autophagy in the limb skeletal muscle.Molecular and cellular biochemistry · 2021Article
- Amino Acid Trafficking and Skeletal Muscle Protein Synthesis: A Case of Supply and Demand.Frontiers in cell and developmental biology · 2021Review
- REDD1 loss reprograms lipid metabolism to drive progression ofGenes & development · 2020Article
- Interactions of the super complexes: When mTORC1 meets the proteasome.The international journal of biochemistry & cell biology · 2019Review
- Disruptions to the limb muscle core molecular clock coincide with changes in mitochondrial quality control following androgen depletion.American journal of physiology. Endocrinology and metabolism · 2019Article
- Exercise and the control of muscle mass in human.Pflugers Archiv : European journal of physiology · 2019Review
- Regulation of Ribosome Biogenesis in Skeletal Muscle Hypertrophy.Physiology (Bethesda, Md.) · 2019Review
- Molecular Regulation of Exercise-Induced Muscle Fiber Hypertrophy.Cold Spring Harbor perspectives in medicine · 2018Review
- REDD1 induction regulates the skeletal muscle gene expression signature following acute aerobic exercise.American journal of physiology. Endocrinology and metabolism · 2017Article
- Castration alters protein balance after high-frequency muscle contraction.Journal of applied physiology (Bethesda, Md. : 1985) · 2017Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
The overload-induced increase in muscle mass is accompanied by protein accretion; however, the initiating events are poorly understood. Regulated in Development and DNA Damage 1 (REDD1), a repressor of the mechanistic target of rapamycin in complex 1 (mTORC1), blunts the elevation in protein synthesis induced by acute muscle contractions. Therefore, this study was designed to determine whether REDD1 alters the rate of the overload-induced increase in muscle mass. Wild-type (WT) and REDD1-null mice underwent unilateral functional overload (OV) of the plantaris, while the contralateral sham leg served as a control. After 3 and 5 days of OV, puromycin incorporation was used as a measurement of protein synthesis. The percent increase in plantaris wet weight and protein content was greater in REDD1-null mice after 3, 5, and 10 days OV. The overload-stimulated rate of protein synthesis in the plantaris was similar between genotypes after 3 days OV, but translational capacity was lower in REDD1-null mice, indicating elevated translational efficiency. This was likely due to elevated absolute mTORC1 signaling [phosphorylation of p70S6K1 (Thr-389) and 4E-BP1 (Ser-65)]. By 5 days of OV, the rate of protein synthesis in REDD1-null mice was lower than WT mice with no difference in absolute mTORC1 signaling. Additionally, markers of autophagy (LC3II/I ratio and p62 protein) were decreased to a greater absolute extent after 3 days OV in REDD1-null mice. These data suggest that loss of REDD1 augments the rate of the OV-induced increase in muscle mass by altering multiple protein balance pathways.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.