ArticleScientific reports2016
Magnetic Resonance Imaging of Phosphocreatine and Determination of BOLD Kinetics in Lower Extremity Muscles using a Dual-Frequency Coil Array.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- Pooled it
- Triple-tuned birdcage and single-tuned dipole array for quadri-nuclear head MRI at 7 T.Magnetic resonance in medicine · 2024Article
- Phosphorus metabolism in the brain of cognitively normal midlife individuals at risk for Alzheimer's disease.Neuroimage. Reports · 2022Article
- Interleaved and simultaneous multi-nuclear magnetic resonance in vivo. Review of principles, applications and potential.NMR in biomedicine · 2022Review
- A radially interleaved sodium and proton coil array for brain MRI at 7 T.NMR in biomedicine · 2021Article
- Lower extremity MRI following 10-week supervised exercise intervention in patients with diabetic peripheral neuropathy.BMJ open diabetes research & care · 2021Article
- Simultaneous TMagnetic resonance in medicine · 2021Article
- High-Resolution DynamicIEEE transactions on bio-medical engineering · 2020Article
- Water-fat separation in spiral magnetic resonance fingerprinting for high temporal resolution tissue relaxation time quantification in muscle.Magnetic resonance in medicine · 2020Article
- A dual-tunedMagnetic resonance in medicine · 2020Article
- Dynamic phosphocreatine imaging with unlocalized pH assessment of the human lower leg muscle following exercise at 3T.Magnetic resonance in medicine · 2018Article
- An eight-channel sodium/proton coil for brain MRI at 3 T.NMR in biomedicine · 2018Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Magnetic resonance imaging (MRI) provides the unique ability to study metabolic and microvasculature functions in skeletal muscle using phosphorus and proton measurements. However, the low sensitivity of these techniques can make it difficult to capture dynamic muscle activity due to the temporal resolution required for kinetic measurements during and after exercise tasks. Here, we report the design of a dual-nuclei coil array that enables proton and phosphorus MRI of the human lower extremities with high spatial and temporal resolution. We developed an array with whole-volume coverage of the calf and a phosphorus signal-to-noise ratio of more than double that of a birdcage coil in the gastrocnemius muscles. This enabled the local assessment of phosphocreatine recovery kinetics following a plantar flexion exercise using an efficient sampling scheme with a 6 s temporal resolution. The integrated proton array demonstrated image quality approximately equal to that of a clinical state-of-the-art knee coil, which enabled fat quantification and dynamic blood oxygen level-dependent measurements that reflect microvasculature function. The developed array and time-efficient pulse sequences were combined to create a localized assessment of calf metabolism using phosphorus measurements and vasculature function using proton measurements, which could provide new insights into muscle function.
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Registered trials
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