Evidence map›Paper›PMID 27465520›Full record

ArticleScientific reports2016

Polymorphisms in TCF7L2 gene are associated with gestational diabetes mellitus in Chinese Han population.

Dan Ye, Yang Fei, Qi Ling, Weiwei Xu, Zhe Zhang, Jing Shu, Chengjiang Li, Fengqin Dong

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Molecular Biomarkers for Gestational Diabetes Mellitus.International journal of molecular sciences · 2018
    Review
  10. Oncotarget · 2017
    Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Dan YeDepartment of Endocrinology and Metabolism, the First Affiliated Hospital, College of Medicine, Zhejiang University, Zhejiang, China.
Yang FeiDepartment of Metabolism and Endocrinology, People's Hospital of Fuyang City, Zhejiang Province, China.
Qi LingKey Lab of Combined Multi-Organ Transplantation, Ministry of Public Health, Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, the First Affiliated Hospital, College of Medicine, Zhejiang University, Zhejiang, China.
Weiwei XuDepartment of Endocrinology and Metabolism, the First Affiliated Hospital, College of Medicine, Zhejiang University, Zhejiang, China.
Zhe ZhangDepartment of Endocrinology and Metabolism, the First Affiliated Hospital, College of Medicine, Zhejiang University, Zhejiang, China.
Jing ShuDepartment of Reproductive Endocrinology, People's Hospital, Zhejiang Province, China.
Chengjiang LiDepartment of Endocrinology and Metabolism, the First Affiliated Hospital, College of Medicine, Zhejiang University, Zhejiang, China.
Fengqin DongDepartment of Endocrinology and Metabolism, the First Affiliated Hospital, College of Medicine, Zhejiang University, Zhejiang, China.
Zhejiang University · CNFuyang City People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed to investigate the possible association between diabetes susceptibility gene transcription factor 7-like 2 (TCF7L2) and gestational diabetes mellitus (GDM) in a Chinese Han population. A total of 556 GDM patients and 500 Non-GDM were included. Eighteen single nucleotide polymorphisms (SNPs) were evaluated. Fifteen tag SNPs were selected from HapMap CHB database with a minor allele frequency of >0.2 and r(2) of >0.8. Three additional SNPs were also chosen because these SNPs are associated with type 2 diabetes in East Asians. TCF7L2 rs290487, rs6585194, and rs7094463 polymorphisms were found to be significantly associated with GDM. In multivariate analysis, rs290487 genetic variation (OR = 2.686 per each C allele, P = 0.002), pre-BMI > 24 kg/m(2) (OR = 1.592, P = 0.018), age > 25 years (OR = 1.780, P = 0.012) and LDL-C > 3.6 mmol/L (OR = 2.034, P = 0.009) were identified as independent risk factors of GDM, rs7094463 genetic variation (OR = 0.429 per each G allele, P = 0.005) was identified as independent protect factor of GDM. This finding suggests that TCF7L2 rs290487, and rs7094463 were a potential clinical value for the prediction of GDM.

Indexed as

Genetic Predisposition to DiseasePolymorphism, Single NucleotideAsian PeopleDiabetes, GestationalFemaleGenetic Association StudiesHumansPregnancyTranscription Factor 7-Like 2 ProteinTCF7L2 protein, humanTranscription Factor 7-Like 2 Protein

Identifiers

PMID27465520
PMCPMC4964615
OpenAlexW2503369196

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.