ArticleThe American journal of clinical nutrition2016
Sugar-sweetened beverage consumption and genetic predisposition to obesity in 2 Swedish cohorts.
Article in The American journal of clinical nutrition, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 4 of them syntheses that pooled it.
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Who cites it
41 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Interactions between Polygenic Risk of Obesity and Dietary Factors on Anthropometric Outcomes: A Systematic Review and Meta-Analysis of Observational Studies.The Journal of nutrition · 2024Pooled it
- Pooled it
- Associations ofNutrients · 2019Pooled it
- Pooled it
- Interactions between genetic predisposition to obesity, insulin resistance and type 2 diabetes risk, and food or beverage intake for incident type 2 diabetes: European Prospective Investigation into Cancer and Nutrition (EPIC) InterAct case-cohort study.The American journal of clinical nutrition · 2026Article
- Interaction between polygenic scores and dietary intake in relation to BMI in Canadian children.Journal of nutritional science · 2026Article
- Sweet Taste Receptors' Genetic Variability in Advanced Potential Targets of Obesity.Nutrients · 2025Article
- Article
- The associations between the energy and timing of sugar-sweetened beverage intake and phenotypic age acceleration in U.S. adults: a cross-sectional survey of NHANES 2007-2010.BMC public health · 2025Article
- Global burden and temporal trends of tuberculosis attributable to high sugar-sweetened beverage consumption: insights from the Global Burden of Disease Study 2021.Frontiers in nutrition · 2025Article
- Deciphering the Interplay between Genetic Risk Scores and Lifestyle Factors on Individual Obesity Predisposition.Nutrients · 2024Article
- A genomics perspective of personalized prevention and management of obesity.Human genomics · 2024Review
- The Interaction Between Body Mass Index Genetic Risk Score and Dietary Intake on Weight Status: A Systematic Review.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024Review
- Interaction between genetic susceptibility to obesity and food intake on BMI in Finnish school-aged children.Scientific reports · 2023Article
- Drinking Habits and Physical Activity Interact and Attenuate Obesity Predisposition ofNutrients · 2023Article
- Attitudes of Chinese residents toward sugar-sweetened beverage tax and their willingness to pay: a cross-sectional survey.Frontiers in nutrition · 2023Article
- Healthy beverages may reduce the genetic risk of abdominal obesity and related metabolic comorbidities: a gene-diet interaction study in Iranian women.Diabetology & metabolic syndrome · 2022Article
- Interactive effects of the low-carbohydrate diet score and genetic risk score on Hypo-HDL-cholesterolemia among Korean adults: A cross-sectional analysis from the Ansan and Ansung Study of the Korean Genome and Epidemiology Study.Food science & nutrition · 2022Article
- Dietary Mediators of the Genetic Susceptibility to Obesity-Results from the Quebec Family Study.The Journal of nutrition · 2022Article
- Sugar Is the Key Cause of Overweight/Obesity in Sugar-Sweetened Beverages (SSB).Frontiers in nutrition · 2022Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
backgroundThe consumption of sugar-sweetened beverages (SSBs), which has increased substantially during the last decades, has been associated with obesity and weight gain.
objectiveCommon genetic susceptibility to obesity has been shown to modify the association between SSB intake and obesity risk in 3 prospective cohorts from the United States. We aimed to replicate these findings in 2 large Swedish cohorts.
designData were available for 21,824 healthy participants from the Malmö Diet and Cancer study and 4902 healthy participants from the Gene-Lifestyle Interactions and Complex Traits Involved in Elevated Disease Risk Study. Self-reported SSB intake was categorized into 4 levels (seldom, low, medium, and high). Unweighted and weighted genetic risk scores (GRSs) were constructed based on 30 body mass index [(BMI) in kg/m(2)]-associated loci, and effect modification was assessed in linear regression equations by modeling the product and marginal effects of the GRS and SSB intake adjusted for age-, sex-, and cohort-specific covariates, with BMI as the outcome. In a secondary analysis, models were additionally adjusted for putative confounders (total energy intake, alcohol consumption, smoking status, and physical activity).
resultsIn an inverse variance-weighted fixed-effects meta-analysis, each SSB intake category increment was associated with a 0.18 higher BMI (SE = 0.02; P = 1.7 × 10(-20); n = 26,726). In the fully adjusted model, a nominal significant interaction between SSB intake category and the unweighted GRS was observed (P-interaction = 0.03). Comparing the participants within the top and bottom quartiles of the GRS to each increment in SSB intake was associated with 0.24 (SE = 0.04; P = 2.9 × 10(-8); n = 6766) and 0.15 (SE = 0.04; P = 1.3 × 10(-4); n = 6835) higher BMIs, respectively.
conclusionsThe interaction observed in the Swedish cohorts is similar in magnitude to the previous analysis in US cohorts and indicates that the relation of SSB intake and BMI is stronger in people genetically predisposed to obesity.
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