Evidence map›Paper›PMID 27465361›Full record

ArticleBMC cancer2016

Expression of circadian clock genes and proteins in urothelial cancer is related to cancer-associated genes.

Jorunn Litlekalsoy, Kari Rostad, Karl-Henning Kalland, Jens G Hostmark, Ole Didrik Laerum

Open access · goldAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cancer, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Review
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  4. Review
  5. Review
  6. Research on the circadian clock gene HNF4a in different malignant tumors.International journal of medical sciences · 2021
    Article
  7. New Insights Into Cancer Chronotherapies.Frontiers in pharmacology · 2021
    Review
  8. Review
  9. Casein kinase 1α: biological mechanisms and theranostic potential.Cell communication and signaling : CCS · 2018
    Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Jorunn LitlekalsoyDepartment of Clinical Science, The Gade Laboratory of Pathology, University of Bergen, Bergen, Norway. Jorunn.Litlekalsoy@k1.uib.no.ORCID 0000-0001-7393-1955
Kari RostadInstitute of Biomedical Laboratory Sciences and Chemical Engineering, Bergen University College, Bergen, Norway.
Karl-Henning KallandDepartment of Clinical Science, The Gade Laboratory of Pathology, University of Bergen, Bergen, Norway.
Jens G HostmarkDepartment of Clinical Medicine, Section of Surgery, University of Bergen, Bergen, Norway.
Ole Didrik LaerumDepartment of Clinical Science, The Gade Laboratory of Pathology, University of Bergen, Bergen, Norway.
Haukeland University Hospital · NOUniversity of Bergen · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe purpose of this study was to evaluate invasive and metastatic potential of urothelial cancer by investigating differential expression of various clock genes/proteins participating in the 24 h circadian rhythms and to compare these gene expressions with transcription of other cancer-associated genes.

methodsTwenty seven paired samples of tumour and benign tissue collected from patients who underwent cystectomy were analysed and compared to 15 samples of normal bladder tissue taken from patients who underwent cystoscopy for benign prostate hyperplasia (unrelated donors). Immunohistochemical analyses were made for clock and clock-related proteins. In addition, the gene-expression levels of 22 genes (clock genes, casein kinases, oncogenes, tumour suppressor genes and cytokeratins) were analysed by real-time quantitative PCR (qPCR).

resultsConsiderable up- or down-regulation and altered cellular distribution of different clock proteins, a reduction of casein kinase1A1 (CSNK1A1) and increase of casein kinase alpha 1 E (CSNK1E) were found. The pattern was significantly correlated with simultaneous up-regulation of stimulatory tumour markers, and a down-regulation of several suppressor genes. The pattern was mainly seen in aneuploid high-grade cancers. Considerable alterations were also found in the neighbouring bladder mucosa.

conclusionsThe close correlation between altered expression of various clock genes and common tumour markers in urothelial cancer indicates that disturbed function in the cellular clock work may be an important additional mechanism contributing to cancer progression and malignant behaviour.

Indexed as

AneuploidyCircadian Rhythm Signaling Peptides and ProteinsGene Expression Regulation, NeoplasticHumansNeoplasm InvasivenessNeoplasm MetastasisTranscription FactorsUrinary Bladder NeoplasmsUrotheliumCircadian Rhythm Signaling Peptides and ProteinsTranscription FactorsCasein kinasesCircadian clock genesOncogenesTumour suppressor genes and cytokeratins

Identifiers

PMID27465361
PMCPMC4964027
OpenAlexW2485924001

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.