ArticleObesity (Silver Spring, Md.)2016
Increased aerobic capacity reduces susceptibility to acute high-fat diet-induced weight gain.
Article in Obesity (Silver Spring, Md.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 22 citations in OpenAlex.
- Reduced liver mitochondrial energy metabolism impairs food intake regulation following gastric preloads and fasting.Molecular metabolism · 2025Article
- Divergence in aerobic capacity and energy expenditure influence metabolic tissue mitochondrial protein synthesis rates in aged rats.GeroScience · 2024Article
- Parental cardiorespiratory fitness influences early life energetics and metabolic health.Physiological genomics · 2024Article
- Intrinsic cardiorespiratory fitness modulates clinical and molecular response to caloric restriction.Molecular metabolism · 2023Article
- Low Aerobic Capacity Accelerates Lipid Accumulation and Metabolic Abnormalities Caused by High-Fat Diet-Induced Obesity in Postpartum Mice.Nutrients · 2022Article
- Differential weight loss with intermittent fasting or daily calorie restriction in low- and high-fitness phenotypes.Experimental physiology · 2021Article
- Reduced Liver-Specific PGC1a Increases Susceptibility for Short-Term Diet-Induced Weight Gain in Male Mice.Nutrients · 2021Article
- Identification of Effective Programs to Improve Access to and Use of Trails among Youth from Under-Resourced Communities: A Review.International journal of environmental research and public health · 2020Review
- Low-intensity exercise induces acute shifts in liver and skeletal muscle substrate metabolism but not chronic adaptations in tissue oxidative capacity.Journal of applied physiology (Bethesda, Md. : 1985) · 2019Article
- Rats Selectively Bred for High Voluntary Physical Activity Behavior are Not Protected from the Deleterious Metabolic Effects of a Western Diet When Sedentary.Current developments in nutrition · 2019Article
- Intrinsic High Aerobic Capacity in Male Rats Protects Against Diet-Induced Insulin Resistance.Endocrinology · 2019Article
- Intrinsic (Genetic) Aerobic Fitness Impacts Susceptibility for Metabolic Disease.Exercise and sport sciences reviews · 2017Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
objectiveAerobic capacity is the most powerful predictor of all-cause mortality in humans; however, its role in the development of obesity and susceptibility for high-fat diet (HFD)-induced weight gain is not completely understood.
methodsHerein, a rodent model system of divergent intrinsic aerobic capacity [high capacity running (HCR) and low capacity running (LCR)] was utilized to evaluate the role of aerobic fitness on 1-week HFD-induced (45% and 60% kcal) weight gain. Food/energy intake, body composition analysis, and brown adipose tissue gene expression were assessed as important potential factors involved in modulating HFD-induced weight gain.
resultsHCR rats had reduced 1-week weight gain on both HFDs compared with LCR. Reduced HFD-induced weight gain was associated with greater adaptability to decrease food intake following initiation of the HFDs. Further, the HCR rats were observed to have reduced feeding efficiency and greater brown adipose mass and expression of genes involved in thermogenesis.
conclusionsRats with high intrinsic aerobic capacity have reduced susceptibility to 1-week HFD-induced weight gain, which is associated with greater food intake adaptability to control intake of energy-dense HFDs, reduced weight gain per kcal consumed, and greater brown adipose tissue mass and thermogenic gene expression.
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